<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27619

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDPRDTAREALRDSVKCWSDFVSKCLTKRLDAGPFEEYVKLVFARHPLTPEVIADFLLQPQASNCVSPDPRIPPYVSVLTQLRYIDAVSILRSLYRYSSLHAQTPLQTQGHGQDQHQDQDHHHHHHQQQQQQPPQEREQQKEGEQEAKDAPPKEHEHEHEHEKTLLGDVTRDPQHDTLRPSRTRWKSSSWLEEVMFYHVIRLVVEGTASKDSRTALELIHVTSKWMSLFAAASNSMAAEMLSGTLQDPQIRHDMEVSRAAFVPLLLRLVDNPALVKIISHPSAKALRKEFSDSLTSFVHVFQPVPPFVEKLEMFRTEVLAPLDPTEKNNQAANAMDELLDSTVGLDNLMIPDMPITNTRAGLYVYLGASLVGRPLIDDHAFFSYLNNRYQGNNQQSAIDLILASFDLLANAVFRNEGPRDAHLLRSFLTNKVPLILGQLCPPGFSTPSAEFCITQALSQVDTSVFPTASLMFDESRNNNPYTESVREEFCSACALHGLIEREHVERILGESSMSYEPSQEKYSKEKLVQSCLSDPDKIQALVRDMDKMDGNVGAVCQALVELLRQLCNSKDTMSLKILCSQLAQKPQSLDVLLLFEKLPTILDPICQLLDGWRYEEDQGEYQPVYEEFGAILLLVLAFAYRYSLFPADIGILATDSSVAKIIGRAHISRGLDRLSEQEHGHLGGWIHGLFDSDAGGLGDDLMSSCPPAEFYLLIATLFENIVIAYTQGSLTDDSLKSGVEYLVDTFLLPSLIPAIRFLSDYLWVEQKEQKSIIKILQLILLPTSISGEASTMLASVKGIIAKPLEHSLRAYQRQDPKNQDIEPLLRALKDSLPHSRRTGAAEHQELEMWTASSSSGLAGAAKHLIQNLVQWGMHPQMTAMPTSYTHRQMIATLKIVGANRLLRVMLEEIRQQTLAGSGSIAYDVVTALVCAPNVSNELPLTSGLLDETGSLPPPLQRRLTLREVLKMEAENYRRLHKKDPELAEITVRLYRRVEAQLVLPPPPTMLQAADMQLDLAGDATGLGDAMAAAAGVQGDGTMAIDGVGNLDMSIGGVSADLGLGASGNNGGLDASAEADLFGGLDTDMDVFDGWSGMDLGGP
Length1098
PositionTail
OrganismHypocrea jecorina (strain QM6a) (Trichoderma reesei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.221
Instability index44.48
Isoelectric point5.14
Molecular weight121614.95
Publications
PubMed=18454138

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27619
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.69|      35|      35|    1017|    1051|       1
---------------------------------------------------------------------------
 1004- 1023 (23.63/ 8.73)	..............TML...QAADMQLDLAGDATGLG
 1024- 1058 (60.44/32.32)	DAMAAAAGVQG.DGTMAI.DGVGNLDMSIGGVSADLG
 1069- 1095 (29.62/12.57)	DASAEADLFGGlDTDMDVfDGWSGMDL..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.70|      24|      35|     119|     142|       2
---------------------------------------------------------------------------
  119-  142 (45.66/28.09)	QDHHHHHHQQQQQQPPQEREQQKE
  153-  176 (42.04/25.29)	KEHEHEHEHEKTLLGDVTRDPQHD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.35|      10|      35|     695|     704|       3
---------------------------------------------------------------------------
  695-  704 (18.88/ 8.87)	GGLGDDLMSS
  728-  737 (17.47/ 7.73)	GSLTDDSLKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.87|      15|      15|     292|     306|       6
---------------------------------------------------------------------------
  292-  306 (28.11/20.12)	DSLTSF.VHVFQPVPP
  309-  324 (21.76/13.71)	EKLEMFrTEVLAPLDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.71|      13|      15|     962|     974|       7
---------------------------------------------------------------------------
  962-  974 (21.82/17.46)	R..EVLKMEAENYRR
  978-  992 (15.89/10.59)	KdpELAEITVRLYRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.07|      41|      49|     518|     559|       8
---------------------------------------------------------------------------
  518-  559 (63.89/51.96)	SQEKYSKEKLVQSCLSDPDKIQALVRdMDKMDGNVGAVCQAL
  569-  609 (67.17/49.27)	SKDTMSLKILCSQLAQKPQSLDVLLL.FEKLPTILDPICQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.23|      15|      15|     802|     816|       9
---------------------------------------------------------------------------
  802-  816 (27.21/16.87)	KPLEHSLRAYQRQDP
  819-  833 (25.02/14.89)	QDIEPLLRALKDSLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27619 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HAQTPLQTQGHGQDQHQDQDHHHHHHQQQQQQPPQEREQQKEGEQEAKDAPPKEHEHEHEHEKTLLGDVTRDPQHDTLRPSRTR
101
184










Molecular Recognition Features






MoRF SequenceStartStop




NANANA