<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27613

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTGEYETNTLLINNVSSIAYRLYEPASNLSQTFASTALDIENSLRERGYVVLYDATKRGLWHFQFLPKEARLDDLGDGLELPPDVTGQGLAVKEHGVIEPPIIQKPRSQAPQSSLTPTSLLSTSSPLEQAHRPTLSSPLQTTAPASQDLDPKAEAKLKATTAQRALYEKLIASVLSTLSTSFCRRTGAIPLNYRTVLLAPTAYNAQPHAVAVGRPQILGTFRVYLTTTGAMMISLALTKCRGILSLDDAVPSGLAPPGYSVLAAPFGIMTAAQSSVPGGDGSMSLAQTPMTQFFNFRGGVDGQESVWKQACLRFLNFRGITASTLEGCLWVNLFVPKPKNPDSRGDQRLSSANSSFTLPWPRRLCFRKKNVDASSTSRVVDAVLSGHEESHDPLGNARGWYAAVTEREEKAKRAMERAATLLKEQNQNPESRTPKPSGLSPVALQRPNTATAGIMYPTPPDGVHQANGVTPSIDGTLSSPGNPLSAPMVTEADAIVQHEPSNGDSLDQPLEFAESKRQRSDSNILGDSAPLLPVQMAASLPHHPSAPLPAPIAAQAASPALAPISSALPPPPHAALPPPPLPPPQDRVVFAKPELKHARSQNDDQARRSRGDVRVTPAKRESSPFDPYAVFKRVRASLNSKGSSQPSLRKAKVFESLDFDPALPLINKKYEQGGFFDPNTLSRVEKMEKASSDLRTVPETDYLKRHGKVNRRPRERPMTRSAMSKPYSALELHGSTGSPMKLDASLSEGEESSVESDQDDSSYTSDEAGSPHKASIRLINGDDDILSQITSLRDGDIEEPDHQLAMELPRLSKSDTSGAPLSSLFSDPEPLALDMALSDDDMIQIAQIVTEQAATGGLDIFRASDFEPSTLSASQKRQELSSYGRDAFHTLEEVVAQFFEDTMPMRLKGLLDIQDVPLLSQFQPRPMQGRDGNSEAMRPSNLYQIPSPHLEVQRADMKLSVLPSAVSFWESLGLSPSSGSKNINAFCVFPGWPGMGDNVLTFLDRIKSVYEFLKLGTFDVMPLGADLEPGLLPYEVDRITTSPDATVTGHGSAMIESLEALRGLFTSLSITETNFVIYFVYSPDNPGTIIESCTAFQRFFETYQKILATRKEPPQNELVLQLVSADLLSSPTAFVVTPTPDLIRLCIETYDRCTLFGGPMPAPAIRLEQLLPRIIDFKLTTNPSASLIRENSCIHVAYAQSVDERWITAAWTDDRGNQQATASYCLARKGKPPSRNMNDIAHEIWETTLELISAWKVLWRVIITKCGPMPQHEMDFWVDLARTEINAKVTVALLTVDTNPSLQLLPPVVRLPPPSAALHTPVSTPQPSVLSPEQIATPATPAREANVATAATPSGDGGASNTSTADADADAILVDVTDQTWGAIAGHRLSNSTSILEVQPALISGYLIKRTGIRVEDAPVAMEVNLVYTEATPRVHEPLFREMLGYFRGLGTLARARGVVDREGDVRPWHVAAAEKAARALYLLM
Length1486
PositionKinase
OrganismHypocrea jecorina (strain QM6a) (Trichoderma reesei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.290
Instability index46.74
Isoelectric point5.54
Molecular weight161491.95
Publications
PubMed=18454138

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27613
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.49|      20|      20|     531|     550|       1
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  531-  550 (40.50/15.17)	P.LLPVQMAASLPHH...PSAPLP
  560-  583 (33.99/11.58)	PaLAPISSALPPPPHaalPPPPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.51|      18|      18|     280|     297|       2
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  280-  297 (34.70/22.73)	G.DGSMSLAQTPMTQFFNF
  300-  318 (30.80/19.32)	GvDGQESVWKQACLRFLNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.09|      17|      21|     488|     506|       3
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  488-  506 (28.15/19.61)	PMvtE.ADAIVQHEPSN..GDS
  510-  529 (21.94/ 9.33)	PL..EfAESKRQRSDSNilGDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.65|      14|      24|     601|     624|       4
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  340-  353 (26.45/ 8.47)	KNPD....SRGDQRLSSA
  602-  619 (21.20/23.04)	QNDDqarrSRGDVRVTPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.98|      19|      22|     435|     455|       5
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  435-  453 (34.81/13.83)	PKPSGLSPVALQRPNT..........ATA
  458-  472 (28.37/11.61)	PTP....PDGVHQANG..........VTP
 1326- 1354 (26.80/ 7.84)	PQPSVLSPEQIATPATpareanvataATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.64|      22|      23|     744|     766|       6
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  744-  765 (37.47/14.05)	DASLSEGEES..SVESDQD.DSSYT
  767-  791 (28.17/12.26)	DEAGSPHKASirLINGDDDiLSQIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.85|      20|      24|     920|     941|       7
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  920-  941 (29.88/26.18)	LSQFqPRP...MQGRDGNSEAMrPS
  943-  965 (30.96/16.97)	LYQI.PSPhleVQRADMKLSVL.PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.54|      13|      15|     118|     130|       8
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  118-  130 (23.52/12.58)	PT..SLLSTSSPLEQ
  134-  148 (20.02/ 9.41)	PTlsSPLQTTAPASQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.27|      19|     742|     319|     339|      11
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   48-   69 (33.16/18.11)	RGyvvLYDATKRG.LWHFQFLPK
  319-  338 (31.11/29.51)	RG...ITASTLEGcLWVNLFVPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.00|      10|      19|     977|     987|      13
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  977-  987 (14.25/11.82)	PSSGSkNINAF
  994- 1003 (19.75/11.35)	PGMGD.NVLTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.39|      11|      22|    1156|    1167|      16
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 1156- 1167 (17.37/14.06)	LFGGPmPAPAIR
 1180- 1190 (19.02/ 9.25)	LTTNP.SASLIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.69|      11|      24|     805|     816|      17
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  805-  816 (14.76/13.72)	LAMELPrLSKSD
  832-  842 (18.93/11.48)	LALDMA.LSDDD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27613 with Med13 domain of Kingdom Fungi
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