<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27609

Description Predicted protein
SequenceMTSRTPIGVHPRPPQRALSSSTLPSVQRPPPQQRALSQQLFPSSPIRKDSILSDASSDSFDPVQAQSHGANQAQIHGRPVSTPRRVGSRLRLELSNIDPVVGNAASASVSASASASVSAASSPQSHTTSRVPSMADAADVGDSSPAPSRASAADVDNDNQPLPMPRRRPPTSQTNSELSKRLAAPSRAAPTLKKDGRPKPWTVEVPKGAPRYPSTEKRPNPTGGDPFSRGLFSGHADFFPWHGGNGKHHEDDWSPEAIQKGTWDRGNQNETSSARMTISPAIKQKSGLSALSTIFMGVLNQRRHRGHVTAPSTFKPPPRVTLTDTKREVWMKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKSVPTERAVWLAKCVGANEIRAFKRKGAPGGAFAIAGEFKWIRDWTVFVEQFIESITSAFGEPDWKAKVTYAIRLATNLYAEQLLDRDHYLDWITSGLEHSPQSKIPMWILIAQICWADILRSRKYGRRLVYSILGHLHTIHSHPDKDILIQLSSQLSTLLASLIKNNPDSFIDPALWPKYKDALEAFLPRDDKAGREAYQHVNARNSQVSITTTASPAVGRPQLVRLLDATLLGQIDRDLPQKCWATGDDKVDIVRTTVDWATSFYRPGLARVYIAANLIKVWSTLRINVTATILEHMDTIPAGDGGRKQMVYHLVTELVRTGQFLVSQYFQWLVARGACSHPSEVDSDDAPCTTRLLVHLPIRYLTEDQKDDRANLLRRAANYSAAEEANDISNSLMCVNHTLGLPLQGDTMAGRRPIPLRKLLPRILSSSKALQTAVGLHLRETVLRLVKSVQPVSLRIFSAIRTILEATQDFYALCDVLKLCSKTTNIEVLASCVDTVNLHLQVFYAQGGAERLFTIFFERLKAINQEQGLVSRPLLAALCFLSRRMPSRQELSKYLAHELTQSDRNNATDACSPISDNMVNPPSGADGEVSEQIEKLLASGNSIDYPTMNRLFGYIIRRLEAGWAKMDDNRRVHASLLTRLRLFDAQHFDKLMSDWVGRVRLLKSRQRLDAVFPLLIITDALPIAFLELLHLILSRLPADTDLSQEEAYRFGIYQRAIQLNHYKGLLSLIRHAAVEYADLRARVGDAKLPLDDGTYRESVLDALRLLVVVHTADVTEAFSPKNIPPSGFRLIHEMISNLFQQAGRLGSPFTAAYDEILRLTNELTMPFCQVKLNMDLSISPPRPTEGEDGQRQPSPSQFDLFAKAMDRAIEAQNIMWTTMLPCLSEDISRHLQSQARSRFLALVPTPSSLSSSKAPTNPQNPSANSNNLYLAEKLLGVIEAIVVGQPPPNTAQLNSVVADRLSDLVEIVVATKIREGKTAGVLGPIFKHWLPMLLKFVLLHSVSLEPMSASVMTTSAQGKLVMPPHHEARAHTVLALCRLFLALEALPSHLVGGGLRQQVFDVATVLADGLPDDLRLHCAKSILLLPGMMPNLHTSSDARLHYILSVPQMSPMDSLMLAHREKTTMPHSTAARGMGAMYGIGPASQEKLSPYVLRRWELLSEPTPNVGVNDTSLSLSLFEAIRLH
Length1553
PositionKinase
OrganismHypocrea jecorina (strain QM6a) (Trichoderma reesei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.230
Instability index49.25
Isoelectric point9.31
Molecular weight171714.80
Publications
PubMed=18454138

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27609
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     437.85|     149|     205|    1041|    1244|       1
---------------------------------------------------------------------------
 1041- 1209 (222.20/162.27)	FPLLI..ITDAL.PIAFLELLHLIlsrlPADTDLSQEEAYRFGIYQRAIQLNHY..KGLLSLIrhAAVEyadlrarVGDAklPLDDGTYRESVLDALRLLV.VVHTADVTEA.....FSP..KNIPPS..GFRLIH....EMISNLFQQAGRLGSPFTAAYDEIlrlTNELTMPFCqvKLNMDLSISP
 1249- 1416 (215.65/164.78)	LPCLSedISRHLqSQARSRFLALV....PTPSSLSSSKAPTNPQNPSANSNNLYlaEKLLGVI..EAIV.......VGQP..PPNTAQLNSVVADRLSDLVeIVVATKIREGktagvLGPifKHWLPMllKFVLLHsvslEPMSASVMTTSAQGKLVMPPHHEA...RAHTVLALC..RLFLALEALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.43|      46|     204|     619|     704|       2
---------------------------------------------------------------------------
  310-  355 (82.52/45.14)	APSTFKPP.PRVTLTDTKREVWMKDLANPAISLRRLSRTIPHGIRGR
  626-  672 (75.91/109.58)	ATSFYRPGlARVYIAANLIKVWSTLRINVTATILEHMDTIPAGDGGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.15|      31|     204|     180|     220|       4
---------------------------------------------------------------------------
  146-  177 (52.20/24.56)	APSRAsAADVDNDNQPLPMPRRRPPTSQTNSE
  184-  214 (57.95/30.31)	APSRA.APTLKKDGRPKPWTVEVPKGAPRYPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     258.11|      83|     402|     508|     614|       6
---------------------------------------------------------------------------
  508-  614 (111.27/118.54)	PDKDiliQLSSQLSTLLASLIKNNPDSFIDPalwpkYKDALEAflPRDDKAGREAYQHVNARNSQVSItttaspavGRPQLVRlldatLLGQIDRDLpQKCWATGDD
  915-  997 (146.84/90.19)	PSRQ...ELSKYLAHELTQSDRNNATDACSP.....ISDNMVN..PPSGADGEVSEQIEKLLASGNSI........DYPTMNR.....LFGYIIRRL.EAGWAKMDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27609 with Med12 domain of Kingdom Fungi
Unable to open file!