<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27608

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNNLPDEIIHITQGFVPLSLLLTRLAQSTHNMVQDKIAELAKMPLPAAAMNGNTNYTQSAPDDTSNENIRKKAALLHFAQDMHAKWVKALVIVEWSRKASMVSKLIDLKYHIDQQRILYDAALDGMINVKRDLTYARIPSPDLKTALQVLSTGTAPWMPDLNYIEPPPLTAEEQLRGIGDLDTLLSLRLNLDDFDKIPPQFRDYTIESGRVTFKVAGEFEVDLTIADEDFEKQFWFIDFRFAFRPASTSLPDSLRTLLENCVNEALAKDGLTGCYQFLHEFVLTAKINELRRQALHLSRTSWTGTLAVERLNRAVAIQYWTSRSPATGLKSWVIVAVNSGRKQGGRPDPKASSHLVAKWYRDGKEVKDAEIQLNAESLSAESLLNDIVGRHIEFILSSIHTGLLATPRFKNRETGVVLNISKSDPGASSLTLQVGYGGTVSLLIEPTSGMFAMKPHSRFSIQPELQLNNGKNPAEDGVTFLEHLRCAIIEDELGRMGTARGWSVRKSPINVDELRSITKMRRWSRALWLQHGGWGPTWFVGVILSLDGDEWWLIETDPAHPNGASKFHTRLPLNKGTPQLSGAFWDNLNQFAASMITQSVDMRELHRRRIKCQANGSIDLSLPPQVRIPAIEVALSAIFPSIMPDDAEDAGSQNSSNLELHSDRDMLALLRSKAGISSSTKEAWAENVVAIKFKRADSELRQATGDGGQMMIHDLVCTSEVAIKVRRPMKFLALEGLRSRDVCYSVATSEFILRVKRRATEPIFDILKSRIKAIDRFVNFLEAMEKAKGSITSPSMTLKKEDGTSAAPAAPEEWRVELDLSSEDIDIHMDPNNPHLKVIDIARTLANSDNGISLLMVWLPITFYAVKAIKDLDAQWLEPSMKELGYLNFSMESMGWIVIKYHTFTKGRNNGERTARRVVCLHLRIRPRRGEGWWHAQRVGAAAASGGGANPPPSSDDEFDQALKKTVWDGKGKHWVGLSSGAAAAANEGVMEMLFAIDGAIRAALTGVKREVIALD
Length1016
PositionTail
OrganismHypocrea jecorina (strain QM6a) (Trichoderma reesei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.07
Grand average of hydropathy-0.247
Instability index42.48
Isoelectric point6.95
Molecular weight113087.07
Publications
PubMed=18454138

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27608
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.83|      55|     582|     309|     364|       1
---------------------------------------------------------------------------
  309-  364 (95.14/57.04)	ERLNRAVAIQYWTSRsPATGLKSWVIVAVNSGRKQGGRPDPKASS.....HLVAKWYRDGK
  912-  971 (95.69/53.56)	ERTARRVVCLHLRIR.PRRGEGWWHAQRVGAAAASGGGANPPPSSddefdQALKKTVWDGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     340.03|     110|     582|      11|     125|       2
---------------------------------------------------------------------------
   11-  125 (166.54/152.92)	ITQGfVPLSLLLTRLAQSTHNMVQDkIAELAKMPLPAAAMNGNTNYTQSAPDDTSNENIRKKAAL.LHFAQDMHAkWVKALVIVEWSRKASMVSKLIDLKY.HIDQQriLYDAALDG
  596-  707 (173.49/136.11)	ITQS.VDMRELHRRRIKCQANGSID.LSLPPQVRIPAIEVALSAIFPSIMPDDAEDAGSQNSSNLeLHSDRDMLA.LLRSKAGISSSTKEAWAENVVAIKFkRADSE..LRQATGDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.89|      16|     347|     408|     423|       3
---------------------------------------------------------------------------
  408-  423 (27.27/17.17)	RFKNRETGVVLNISKS
  754-  769 (27.62/17.48)	RVKRRATEPIFDILKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.47|      13|     347|     508|     563|       4
---------------------------------------------------------------------------
  491-  503 (25.65/10.14)	DELGRMGTARGWS
  512-  524 (24.82/55.37)	DELRSITKMRRWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.46|      16|      20|     796|     811|      10
---------------------------------------------------------------------------
  796-  811 (27.27/18.26)	MTLKKED.GTSAAPAAP
  818-  834 (25.19/16.26)	LDLSSEDiDIHMDPNNP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27608 with Med14 domain of Kingdom Fungi
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