<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27604
Description |
Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSFHPQTPQSPSQFSPATSSDPSLGLSGSVAAAGSGTTTLPTPAHSVNGSSSQLDSFIMLDDSPHKRKRPLEDVGDDDREPKKAHVEDGKLALEDLHLDVGPKYLLLQSRKTPSVALVSLLRPWKTRPRQFAGMFFLPFPRSLLSHPESLPRTSEDLYEMFDLTGLAAEVAREKPNGEKNALRKTYKGHIKRLGVAGHFDVQKKKEDSPSDFLAMLQVPDHEWNVHQVKGRALMDGLSEMTKSSLGRALTMAKGPIAKSVWDTSVLGDIGSNGDSSKAPSAKPTAPNTPLISMPGAAMSRPKAQLLSGQSPARPQRSIKKRSYGDSSYEGYGEGFPDDDTGLETGYSTGEGEGGQKRRKKASKKSLDSPSSHHLTSNLLQSSGTTPPYPSAMRQSSYGPGMVGV |
Length | 404 |
Position | Head |
Organism | Hypocrea jecorina (strain QM6a) (Trichoderma reesei) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.673 |
Instability index | 57.05 |
Isoelectric point | 9.26 |
Molecular weight | 43460.35 |
Publications | PubMed=18454138
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP27604
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 49.21| 14| 14| 230| 243| 2
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230- 243 (24.77/14.93) GRALMDGLSEMTKS
246- 259 (24.44/14.64) GRALTMAKGPIAKS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 42.24| 11| 21| 119| 129| 4
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119- 129 (22.03/10.64) SLLRPWKTRPR
142- 152 (20.22/ 9.26) SLLSHPESLPR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 43.89| 13| 21| 193| 205| 5
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193- 205 (22.63/14.86) LGVAGH.FDVQKKK
216- 229 (21.26/13.56) LQVPDHeWNVHQVK
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|