<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27597

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSEEDWPSPKFREHVIQRLEPELARNRQNAPNLPVPGDARQVEEYVFAKCMSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSQFHSPPCTTAALGATTPVGSTPGYRAPVPPDPQPTSAQARNPPPAVATTQATTTPSQSVPTGTVSASAAVAAAVASFPSPDSALRPQPGSQTTPGGAPTQSAAPPFPNGGGAPGGPGAPGGPGGPSMNGSGGPAMGQPPPQMGAPNMGMGGGGPPGYGGYGMMNGPPGGGGPMGGNPYGQGMKKEMDQSRPWDPQGHMYQQQQPQQPPWGGMPPQQGGHGGYPNRPGMNGQGTTPTGTSSVLESLINQPQQYPGHHNPMGAPGGPERAPQGRPGGPGVPGGPGGPGGQRGPNGIPNGSQGVMSVEDQQIYSSKLRNMRGSCDSLRTRARQCRQEGNHEAAHKLEVMLSVLEGKRVVSLEYLNHLETWIARKQDFLNINPMAPNPNHMGMNDPVMNGAEQMMMGNGQVHNPYGGHPGYGHPQYMGGPPPHHMQMHQSQQMWHQQQQQQRMMPQDPMMMGGGGGPMHGMYRGDMGHDQMTSPVNSHRHAPYQNPAMRNNMRQMQNGPGPIGRDRNSMSGSMSGPSSGAPSMNPMGTPSQKMGTPGSMGGLSGLDDFNYDDFLPNPIDALQPTLHVGNPPNQMSSGQSMQRSNLNDAARKELQALEARFEIEQNHPRHDANHFIVTCKIRGQPFPPLRLVVPTTYPSGNVTVDRAAIDLDAYLYDDLQNVVHERLSRPGLTTLSDYLNAWEEQVSQYMQQNPSNGGMDPSFGVGNDFFYDNLNL
Length804
PositionTail
OrganismCaenorhabditis brenneri (Nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.05
Grand average of hydropathy-0.803
Instability index58.97
Isoelectric point6.60
Molecular weight85388.40
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
nuclear hormone receptor binding	GO:0035257	IEA:EnsemblMetazoa
transcription coactivator activity	GO:0003713	IEA:EnsemblMetazoa

GO - Biological Process
determination of adult lifespan	GO:0008340	IEA:EnsemblMetazoa
embryo development ending in birth or egg hatching	GO:0009792	IEA:EnsemblMetazoa
locomotion	GO:0040011	IEA:EnsemblMetazoa
nematode larval development	GO:0002119	IEA:EnsemblMetazoa
regulation of fatty acid metabolic process	GO:0019217	IEA:EnsemblMetazoa
regulation of multicellular organism growth	GO:0040014	IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
sequestering of triglyceride	GO:0030730	IEA:EnsemblMetazoa









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27597
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     332.40|      48|      53|     163|     210|       2
---------------------------------------------------------------------------
  167-  215 (81.18/19.88)	LRPQP...GSQTTP.GGAP..TQSAAP..P..FPNG.GGAPGGP..GA.......P...GGPGGPS...MngSGG.
  216-  249 (47.55/ 8.02)	..PAM...GQ...P....P..PQMGAP..N..MGMG.GGGP..............P...GYGGYGM...MngP...
  283-  324 (54.59/10.50)	..QQQ...QPQQPPwGG........MP..P..QQGGhGGYPNRP..GM.......N...GQGTTPT...G..TSSV
  463-  519 (50.39/ 9.02)	MAPNPnhmGMNDPV.MNGA..EQMMMG..NgqVHNPyGGHP.GY..GH.......PqymGGP.PPHhmqM..HQS.
  520-  564 (54.72/10.54)	QQMWH...QQQQ.........QQRMMPqdP..MMMG.GG..GGPmhGM......yR...GDMGHDQ...M..TSPV
  597-  649 (43.98/ 6.76)	..SMS...GSMSGPsSGAPsmNPMGTP..S..QKMG...TPGSM..GGlsglddfN...YDDFLPN...P..ID.A
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.47|      15|     110|     250|     265|       4
---------------------------------------------------------------------------
  253-  271 (21.42/ 6.78)	GGPmGGNPYGQGMkkeMDQ
  366-  380 (31.05/ 8.45)	GGP.GGQRGPNGI...PNG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27597 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVPSVLQPSQFHSPPCTTAALGATTPVGSTPGYRAPVPPDPQPTSAQARNPPPAVATTQATTTPSQSVPTGTVSASAAVAAAVASFPSPDSALRPQPGSQTTPGGAPTQSAAPPFPNGGGAPGGPGAPGGPGGPSMNGSGGPAMGQPPPQMGAPNMGMGGGGPPGYGGYGMMNGPPGGGGPMGGNPYGQGMKKEMDQSRPWDPQGHMYQQQQPQQPPWGGMPPQQGGHGGYPNRPGMNGQGTTPTGTSSVLESLINQPQQYPGHHNPMGAPGGPERAPQGRPGGPGVPGGPGGPGGQRGPNGIPNGSQGVMSVEDQQIYSSKLRNMRGSCDSLRTRARQCRQEGNHEAAHKLEVMLS
2) DFLPNPIDALQPTLHVGNPPNQMSSGQSMQRSNLNDAARKELQALEARFEIEQ
3) KQDFLNINPMAPNPNHMGMNDPVMNGAEQMMMGNGQVHNPYGGHPGYGHPQYMGGPPPHHMQMHQSQQMWHQQQQQQRMMPQDPMMMGGGGGPMHGMYRGDMGHDQMTSPVNSHRHAPYQNPAMRNNMRQMQNGPGPIGRDRNSMSGSMSGPSSGAPSMNPMGTPSQKMGTPGSMGGLSGLDDF
4) MSEEDWPSPKFREHVIQRLEPELARNRQNAPNLPVPGD
75
641
454
1
431
693
637
38










Molecular Recognition Features






MoRF SequenceStartStop




NANANA