<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27592

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMMPRMGPPTTSRQDNPLHVSFRNPQWPPNFITKENVLDYFCNQANTFYEMNSCNQQIRMQNITNRTVEECLRTMQGIQYVLWYSQPPLFIICKQRRNSVQNVSPISYYYVINGSVHQAPDMYSLVQSRLLGALEPLRNAFGEVTNYSRYNTAKGYYWEFKNKPTVKKREEDKKDEEEERLEDRSTMFQKTRTLTLLNQLLSEMPGDEALEREEVDEEDEPKTEEAAATTTGEPKFAEPAARSTAK
Length245
PositionHead
OrganismCaenorhabditis brenneri (Nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.10
Grand average of hydropathy-0.890
Instability index57.11
Isoelectric point5.34
Molecular weight28606.78
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27592
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.91|      14|      38|      96|     113|       1
---------------------------------------------------------------------------
   96-  109 (26.94/19.24)	RNSVQNVSPIS.......YYY
  137-  157 (21.97/ 6.48)	RNAFGEVTNYSryntakgYYW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.91|      10|      38|     169|     178|       2
---------------------------------------------------------------------------
  169-  178 (16.92/ 9.84)	EEDKKDEEEE
  210-  219 (16.99/ 9.91)	EREEVDEEDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.25|      16|      17|       7|      23|       3
---------------------------------------------------------------------------
    7-   23 (26.72/20.67)	PPTTSRQDNPLHVsFRN
   27-   42 (31.53/19.67)	PPNFITKENVLDY.FCN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27592 with Med6 domain of Kingdom Metazoa
Unable to open file!