<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27574

Description CBN-RGR-1 protein
SequenceMSLVHFAHATRSQFLKLVALVKWIRVSKRMDVCYSVAYLLDLQSQYFTETADRLVSMIRGDLQLARLPEFHIAPAIDVLVLGTYNRMPSKIKEAFIPPAKITPREQKLVTSRLNQLIETRISRISNKIPANFKEIHINNGIATLLVPGEFEIKITLLGETEMIKWSLLNIKILVEDYELGMGLPLVHPLQLNQLHGALQSRMNVSANPIKEAFYFLHSFCVSLQLDALWCQTSRLASGRLRENITIEKYDMKKRTLLVGYWVKRTKSKNLTVGQVKYDAQYRVQIYEDEDDKLGGLKVRHFPHAPQLGTIDCRAGMLSMNRLLSETFSVRCKERLMRLRRIIESADPMLEVTMTGLSVPSLSLALLPDTTANEEMLTVSVNSFCGRVICNINVLSSDNEDVLAFARALYSSRCTNQTIRSYLKKLRVLLVIERYRRSVTSLPVRERRESELLPFVKEVLNQKPAQRIVLQYLRNENYYLIANFVPDEKEYVSIELLLMEIEEERAQFINLDNDNELFTTSVRDATHQGTLKFTQTDKPTLQEECSRHQKLAFAIATIEDRLTYMYLATELVKREIGIELRRDDAHVPGGLALHITDVKSVVPFDVAEFFKCCVRSCLRLDNRNRYTFQFEMCFENIPLVRDVPHGLSHRREGVKDTTWIQEINNVNQVSPDKLVEGILHRLMRYLHMYRVVHKFSLAYEQYFKNMCNIEAYTFHKLVVSYGENRDMLMILAFNVKSQVPGSSEEHYFMNFGQTMPHRQFNSTKVDWHEKPHWNPHSLMASFLREHLRQHHDLVFIMHFLCQTIKPLVAIGNFGRIRFQSQKSLTQMLGPEVHFAFRLKYFLNAIDMTTWRLMQGNVILEIRLLEGDKVAVRDVSRYRARCAGLYQLFANIDPHNTALMADEIAIPPSDNPNTAGPTMWTPDQFMETIDDRHEESDPRMALTSQPILMTHDTIYAACDFDVIEGRLTCPLDEYLCSIGYLQRALLTLERMSPRGNPNQTSPNSLITGYVTVVDAKPDFIRFRATQLNGEGQNTTSMVHYKIYLCPVEMTLKIRIEFDEGTNDQATPENLQILSKYFEKVVFSCGDEYALQSYILMTRVTSFGATNSIAKLMGSQLESPSKCCLQLSLTYNNTSTKKLAAATKVDVQLQNIIFNVIISQSRTSESFSVLRFIYRLKENVVSIPSIDSKQIADDASADAKASGSCAIWVLVSRIVDRFCAGEWNPSNRDEPIIMNVAPPQYGNPASVAPPGSVVQQNSVSQPMQPQSVMAPGSMMGPQSVNAHQYGMHRQQMGGPQSMQMNPSSIGPGSVNAGSMNPGSVLNPGSVMNPGSVLNPGSVMNPGSVMNPGSSMNPGSVMNPGSVMNPGSVMNPGSVMNPGSHQQHMMNPGSVGPGNVGGPGSVNPGGYWNPQAGSGQQQQYPHHPHMQYPP
Length1426
PositionTail
OrganismCaenorhabditis brenneri (Nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.08
Grand average of hydropathy-0.240
Instability index42.17
Isoelectric point8.22
Molecular weight161159.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27574
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     115.05|      13|      16|    1320|    1332|       1
---------------------------------------------------------------------------
 1268- 1279 (19.55/ 6.06)	......PGSMMGPQSVNA
 1314- 1331 (25.95/10.09)	PgsvlnPGSVMNPGSVLN
 1362- 1373 (26.60/10.50)	......PGSVMNPGSVMN
 1374- 1388 (19.91/ 6.29)	P..gshQQHMMNPGSV.G
 1389- 1405 (23.03/ 8.25)	PgnvggPGSV.NPGGYWN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     114.05|      12|      16|    1332|    1343|       2
---------------------------------------------------------------------------
 1235- 1246 (18.73/ 7.06)	PPQYGNPASVAP
 1259- 1267 (18.58/ 6.95)	P...MQPQSVMA
 1304- 1313 (20.72/ 8.57)	PGSV.NAGS.MN
 1332- 1343 (28.01/14.07)	PGSVMNPGSVMN
 1350- 1361 (28.01/14.07)	PGSVMNPGSVMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     305.38|     103|     115|      86|     199|       3
---------------------------------------------------------------------------
   86-  199 (145.94/109.77)	RM...PSKIKEAFIPPAKITpreqklVTSRLNQLiETRISRI.SNKIPANFKEIHINNGIATLLVpGeFEIKITLLGETEM..IKW.SLLNIKILV.EDYELGmGLPLVHPLQLNQLhGALQ
  201-  311 (159.45/88.06)	RMnvsANPIKEAFYFLHSFC......VSLQLDAL.WCQTSRLaSGRLRENITIEKYDMKKRTLLV.G.YWVKRTKSKNLTVgqVKYdAQYRVQIYEdEDDKLG.GLKVRHFPHAPQL.GTID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     111.38|      22|     119|     521|     542|       6
---------------------------------------------------------------------------
  521-  542 (37.89/21.91)	VRDATH.QGTLKFTQTD.KPT..LQ.E
  581-  603 (20.71/ 8.72)	.RDDAHvPGGLALHITDvKSV..VP.F
  613-  630 (23.15/10.60)	VR......SCLRLDNRN.RYT..FQfE
  639-  661 (29.62/15.56)	VRDVPH..GLSHRREGV.KDTtwIQ.E
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.48|      41|     116|     316|     399|       8
---------------------------------------------------------------------------
  316-  361 (58.10/128.70)	MLSMNRLLsetFSVRCKERlmRLRRIIESADPMLEVTMTGLSVPSL
  401-  441 (66.38/35.17)	VLAFARAL...YSSRCTNQ..TIRSYLKKLRVLLVIERYRRSVTSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.61|      35|      58|     932|     966|      10
---------------------------------------------------------------------------
  932-  966 (62.15/45.25)	EESDPR..MALTSQPILMTHDTIYAACDFDVIEGRLT
  987- 1023 (54.10/38.27)	ERMSPRgnPNQTSPNSLITGYVTVVDAKPDFIRFRAT
 1027- 1043 (21.37/ 9.90)	GEGQNT..TS.......MVHYKIY.LC..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.93|      20|      91|     705|     724|      12
---------------------------------------------------------------------------
  682-  703 (24.25/14.71)	MRYLHMYrVVHKFSLAYEQYfK
  705-  724 (34.30/24.12)	MCNIEAY.TFHKLVVSYGEN.R
  726-  745 (30.39/20.47)	MLMILAF.NVKSQVPGSSEE.H
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.83|      17|      20|    1113|    1129|      23
---------------------------------------------------------------------------
 1113- 1129 (30.62/20.78)	QLESPSKCCLQL.SLTYN
 1135- 1152 (22.21/13.04)	KLAAATKVDVQLqNIIFN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27574 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DNPNTAGPTMWTPDQFMETIDDRHEESDPRMALT
2) PASVAPPGSVVQQNSVSQPMQPQSVMAPGSMMGPQSVNAHQYGMHRQQMGGPQSMQMNPSSIGPGSVNAGSMNPGSVLNPGSVMNPGSVLNPGSVMNPGSVMNPGSSMNPGSVMNPGSVMNPGSVMNPGSVMNPGSHQQHMMNPGSVGPGNVGGPGSVNPGGYWNPQAGSGQQQQYPHHPHMQYPP
908
1241
941
1426










Molecular Recognition Features






MoRF SequenceStartStop




NANANA