<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27573

Description Uncharacterized protein
SequenceMDADISDDPNGEPNKNGNEKEKEKEGKKSRTPTPVPEEDKVVEPGVQSWFDNQPGDRMLRKGNLRMGTADIYKQNRNQEEDMLTPERLKKGYQVSGKEMSILKSSNYGLPVTNYELQSLVFNASENKLTRLERAPRKSQSMIASIIHKKGELNMNYDKERKVNRNGVPKFAVHNYKRINEDRVKFFSALSRGEPLDYLKRKIPTFRRKEALFWEFFDYNVPYDRAVWTAKLSCILNFHNSNKTQKKALLDVGTLEMSLACNRITVFMLKKLYKTSAKDDKDEYDEFIEMWDYTTGLMLYMFKDGMVDRNEFLTDLTESFNVFFIRKYLKNVDILCKFLMFYISFIEDVGGTLLVSRRSSTLISQALHMISEGADLKRNFEGYKKSHIDECNQFEQWDMERTLLEMGDIPVDQQPKTREQKKKFFIKFFRQLEEEPYFDEVPEQPIEDHVLDHVVKETAKMNLFEKHEEKMAEDKLSGLRRKAPRKAGTVKKEKFDPLYDKNAGGEQKQKEAEKKAPVAQKPAVFIKSEPMDYEEYGDAGASTSEPTEAPVEPAEPVVTESAGLPGPADDSEPEEITDDEVDWDGASDISDFFYSSPSPSNQSARSLAGSPPNAPHGSLQGSRPASPTKPDNGPSDDSLDDEESEDESSASSIYFTSDSSEESDRATPVRYSPLPIKPLFIPPEKVTLTKEEEFGYLNVGQQAPPPEKVGARYGSLTYSFWDQMGGIAMDRDNADFMDFSTPFPVERPLPVEQPINLNLSPSPSSTPDGEQDGKNSEKKDDEKKDEENNLKEAMETEKEKEKEKEKEKSKELEKEKGKEKETAEEEPTNNVNVPINSEEDEATDATNTDKNAAEELVASKSDDKKEEEKKAEEKKEKANPFTCPDKFEDLMRILESDSLIAVENCSDDEEDEEEQEESEKTSAAGETVEDDGDVYIPPNDDIYPGMEDEFGTCLDPAVLENIPFPPGDPPHFSINPLDYDPALLAFNDMLALGNPMAPVASYAAQYRDEHSDNLNIPLADDDDAMDIDEPEETEHVGDNQDDDCMIIEPEKEPLKEPVKNLEEDDCVVVAVVEADKEPETEQEKSPALAKESENVEQNGANESEKDKEPEIVEENAIAEKDSEAEAGPSTAPPKAPTLARAPLAVPEPARELTEKEKKKMEKQKKIDEIVQENIEFVKERMESDNQWQTGPFHPGFKEWAQAHDNRSRSLLLLSSMLQYLACVTPDSFVWNNLVVPKKERRHRILPQLCGSPLDYLPCELHELPTLDGNEDMIENLRVRHLEILRRSQAAEDKWIQPGADIRKYNRIIDTCVDVVGCLDFIDLEIPGAIKKAANEIFEFRPKFIHSEALLRTKLLFKWCITEEREGSHRAVCAAKLLRYVMDQNPDQTIGGWKAMDLFFSFMTTEGPKYGHPKYQEHFDRAVAILIEMMREKIFSLTELLQDLEREMDIDYANPLMARQRKQRIPKPSKRQLNDEPQDESKLIHYTTSYTPKRLFMGKKLDLLERLLIMLPTLDMDTSSDDYRIRKMLLFGLNANENCHFRRIRAIIKNIENEFETKMYLTFSKSGTSTTKKIHQTQLDEMLRLYRVQTYNDQLVIMGHVSKHFIEGIGGFLNKSSDKVPAPENANIICEMYEYTQDITAIFNFFEMVIPFLKDVDERIVALKLDILPDMYYSEVAFIFVSFFVKHWERFLVHPRACAILNQLMWLISDMITAEGHMITCWGRVVAAFVFHAGETIRKADLVTEPLVAKQGFFTKVWPNLTQHEINTSYFNSAFTGNKLKNKASVLRYESYHDFKVIVANMKVNKKTKNGPKFTNCRYSFVITAFMEACAHGRNFDRINELANYCANVTANDAPLSDYWIAAINSLCCLNTNAPFPFKEMAQKIDVSHTFFLVHMILIFQITDCSTHYSLSTFIFCLAAKSAFFVPTLLFMFWKYIFPLIVVDGRIVVPKPTNPRRRGGAKNTNNKNTQNDAEAGMCLCLMILCKFCCGNDEPIGLSVHYKGIEMKKKRFVSTADERIMHYFHRLDMRQHLFAILTHISNLMEALQSRSKDENFVFPKTFPTTSTQEGKDGEEEEERREKAPYRKEFLFPIVKAVYLTICEQDWVTKQMTMVTTFADMKLYTHPILKHNSLGQLLLRVSLRRRTERENVLQFLEAHKVSKKATVDKLLSFLTLWNFRATFFDLRLMMKEISPDENTRYVQQAAIAADALMSEIGKSCRDVFLKAFKSKTNMPIVKQLGEFRFSDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLREAISLMDTPPQTSKTRLLQCAWVMSRIPFINTVMSCLRSEQTQQGRDVFLQSIYQQLQREVLRNHNRRNKLQNRFEQRECTVLRISWICHIYKEILKPTHVESWGFLIFQMLFHGVVNPDRERLLYDNCFDMLQNMILWTLVDGDTMNQHERYGSVRTRWPQYASLMRKIRRESHDKYFDPQCINLTRILPIGKCQLTTVSYKKFTKRKKAAPAAAPAPRITRRFVAGDGLKNGRYVYLPEEKTKTNAFDKVPEMVEGIQKGGWKFKMFQTTRLNTVAKISLIRIAALFTYPHGQQHQPPAYQQGNNQMQMNMQQQQQARQQAGSQQQQFGASGGMGQQNQPGPSGFSQQMGHGQSGQQQMDQQQNMAQQQQRNPFGGQPEMQQGGAKMLMHAQPDEAHAQQYQHTQNQMTLAQKEREKQYFQAKNVQAAAGQAAGQQPRFGDAGNTSGFGRNPSFGQQQAGGAGNPNPSQAGMQNFQQQPVLGQPGPMQPGGPSAQQQQQLGRSQQQFNPMRPNMGHPQNQMDAGSGNQGLGQTGQSGGYQQPNQNQPMGQQHQQNITQNRSPGQFGRQNQEAGYQQQGFNQGGNQNFQGSENQQNQWQQAGNQGQQQMRPQQTQQPQPQQGQFGRQDQQQQYQQQGGQNPQMQQQQHQQQAQQAQQAQQAQQAQQAQQVQQQQQQPNRFGGMGGHGAQSTNILNQVGSPGVNALLALTFQFGNIIRNLPRVSYIKAIDVWMLSGICFVFASLFELATIGFLMRNEGKPATKSTRVTKNSARWQQPSVCKEDSQKKSKNILYCERLDNTSRLLFPVVFTFYNFIYWFVYMKQAWDQAP
Length3288
PositionKinase
OrganismCaenorhabditis brenneri (Nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.09
Grand average of hydropathy-0.722
Instability index50.50
Isoelectric point5.68
Molecular weight351656.25
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
ion channel activity	GO:0005216	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro
transmembrane signaling receptor activity	GO:0004888	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27573
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     240.03|      20|      21|    2988|    3007|       1
---------------------------------------------------------------------------
 2807- 2824 (30.45/10.21)	SQQMGH..G...QSGQ.QQMDQQQ
 2912- 2930 (31.12/10.59)	NPSFGQ.Q....QAGGAGNPNPSQ
 2988- 3007 (40.08/15.77)	NQGLGQ.TG...QSGGYQQPNQNQ
 3020- 3042 (26.53/ 7.95)	NRSPGQ.FGrqnQEAGYQQQGFNQ
 3045- 3059 (23.26/ 6.05)	NQNF.........QGSENQQNQWQ
 3063- 3083 (28.03/ 8.81)	NQGQQQmRP...QQTQQPQPQQGQ
 3086- 3105 (30.56/10.27)	RQDQQQ.QY...QQQGGQNPQMQQ
 3109- 3128 (30.00/ 9.95)	QQQAQQ.AQ...QAQQAQQAQQAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     273.50|      58|      61|     552|     611|       2
---------------------------------------------------------------------------
  495-  542 (65.85/37.39)	..DPLYDKNAG..GEQKQKEAEK..KAPV....AQKPAVFIKSEPMDYEEYGD....AGAS.T
  552-  611 (99.03/67.07)	PAEPVVTESAGlpGPADDSEPEEITDDEVDWDGASDISDFFYSSPSPSNQSAR..SLAGSP.P
  623-  674 (76.13/44.63)	PASPTKPDN....GPSDDSLDDEESEDE...SSASSI..YFTSDSSEESDRAT..PVRYSPlP
  681-  718 (32.49/13.31)	...................PPEKVTLTKEEEFGYLNVGQ...QAPPPEKVGARygSLTYS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.16|      19|      19|    1028|    1046|       3
---------------------------------------------------------------------------
 1026- 1044 (36.92/28.25)	IDEPEE...TEHVGDNQDDDCM
 1045- 1066 (29.24/20.31)	IIEPEKeplKEPVKNLEEDDCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     301.75|      68|      69|     794|     861|       4
---------------------------------------------------------------------------
  794-  861 (102.76/67.82)	ETEKEKEKEKEKEKSKELE.KE......KGKE.KETAEEEPTNNVNVPINSEEDEATDATNTDKNAAEEL......VASKSD
  863-  932 (92.68/60.24)	KKEEEKKAEEKKEKANPFTcPD......KFEDlMRILESDSLIAVENCSDDEEDEEEQEESEKTSAAGET......VEDDGD
 1072- 1149 (80.72/51.26)	..EADKEPETEQEKSPALA.KEsenveqNGAN.ESEKDKEPEIVEENAIAEKDSEAEAGPSTAPPKAPTLaraplaVPEPAR
 1151- 1183 (25.59/ 9.83)	LTEKEKKKMEKQKKIDEIV.QE......NIEFvKERMESD..........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.92|      15|      68|    2760|    2774|       5
---------------------------------------------------------------------------
 2760- 2773 (23.47/12.03)	.AYQQGNN.....QMQMNMQ
 2935- 2952 (18.57/ 7.31)	N.FQQQPVlgqpgPMQPG.G
 3131- 3144 (26.88/15.31)	QQQQQQPN.....RF.GGMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.44|      13|     140|    2829|    2845|       7
---------------------------------------------------------------------------
 2829- 2845 (17.73/15.63)	QQQRNPFggQPEMqqGG
 2965- 2977 (23.72/ 7.54)	QQQFNPM..RPNM..GH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.81|      32|     140|    1324|    1355|      11
---------------------------------------------------------------------------
 1324- 1355 (54.33/37.75)	IPGAIKKAANEIFEFR....PKFIHSE.........ALL....RTKLLF
 1388- 1434 (34.30/20.35)	IGG..WKAMDLFFSFMttegPKYGHPKyqehfdravAILiemmREKIFS
 1463- 1494 (52.18/35.89)	IPKPSKRQLNDEPQDE....SKLIHYT.........TSY....TPKRLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      86.03|      17|      17|    2852|    2868|      12
---------------------------------------------------------------------------
 2775- 2793 (24.83/11.25)	QQ...QARQQAGsqQQ.QFGASG
 2852- 2866 (20.93/ 8.04)	.....AQPDEAH..AQ.QYQHTQ
 2867- 2885 (20.88/ 8.00)	NQmtlAQ.KERE..KQ.YFQAKN
 2886- 2904 (19.39/ 6.78)	VQ..aAAGQAAG..QQpRFGDAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     221.11|      60|      61|    2473|    2532|      13
---------------------------------------------------------------------------
 2195- 2236 (33.19/18.69)	.TRYVQQAAIAA..........DALMSEIGKSCRDVFLKAfksktnmpIVKQL.......................
 2473- 2532 (108.92/81.55)	KTRLLQCAWVMSRIPFINTVM.SCLRSEQTQQGRDVFLQS........IYQQL.......QREVLRNHNRRNKLQN
 2538- 2594 (78.99/56.71)	E.....CT.VL.RISWICHIYkEILKPTHVESWG..FL..........IFQMLfhgvvnpDRERLLYDNCFDMLQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.55|      22|      63|    1229|    1258|      14
---------------------------------------------------------------------------
  959-  980 (45.13/19.23)	ENIPFPPGDP.....PHFSINPLDYDP
 1230- 1256 (36.42/38.08)	NNLVVPKKERrhrilPQLCGSPLDYLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27573 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APVASYAAQYRDEHSDNLNIPLADDDDAMDIDEPEETEHVGDNQDDDCMIIEPEKEPLKEPVKNLEEDDCVVVAVVEADKEPETEQEKSPALAKESENVEQNGANESEKDKEPEIVEENAIAEKDSEAEAGPSTAPPKAPTLARAPLAVPEPARELTEKEKKKMEKQKK
2) DSLIAVENCSDDEEDEEEQEESEKTSAAGETVEDDGDVYIPPNDDIYPGMEDEFGTCLDPAVLENIPFPPGDPPHFSINPLD
3) FWDQMGGIAMDRDNADFMDFSTPFPVERPLPVEQPINLNLSPSPSSTPDGEQDGKNSEKKDDEKKDEENNLKEAMETEKEKEKEKEKEKSKELEKEKGKEKETAEEEPTNNVNVPINSEEDEATDATNTDKNAAEELVASKSDDKKEEEKKAEEKKEKANPFTCPDKFEDL
4) HGQQHQPPAYQQGNNQMQMNMQQQQQARQQAGSQQQQFGASGGMGQQNQPGPSGFSQQMGHGQSGQQQMDQQQNMAQQQQRNPFGGQPEMQQGGAKMLMHAQPDEAHAQQYQHTQNQMTLAQKEREKQYFQAKNVQAAAGQAAGQQPRFGDAGNTSGFGRNPSFGQQQAGGAGNPNPSQAGMQNFQQQPVLGQPGPMQPGGPSAQQQQQLGRSQQQFNPMRPNMGHPQNQMDAGSGNQGLGQTGQSGGYQQPNQNQPMGQQHQQNITQNRSPGQFGRQNQEAGYQQQGFNQGGNQNFQGSENQQNQWQQAGNQGQQQMRPQQTQQPQPQQGQFGRQDQQQQYQQQGGQNPQMQQQQHQQQAQQAQQAQQAQQAQQAQQVQQQQQQPNRFGGMGGHGAQSTNILN
5) MDADISDDPNGEPNKNGNEKEKEKEGKKSRTPTPVPEEDKVVEPGVQSWFDNQPGDRMLRKGNLRMGTADIYKQNRNQEEDMLTPERLKKGYQVS
6) VKKEKFDPLYDKNAGGEQKQKEAEKKAPVAQKPAVFIKSEPMDYEEYGDAGASTSEPTEAPVEPAEPVVTESAGLPGPADDSEPEEITDDEVDWDGASDISDFFYSSPSPSNQSARSLAGSPPNAPHGSLQGSRPASPTKPDNGPSDDSLDDEESEDESSASSIYFTSDSSEESDRATPVRYSPLPI
7) XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
996
896
719
2752
1
489
2250
1164
977
889
3155
95
675
2450










Molecular Recognition Features






MoRF SequenceStartStop




1) APRSQEETNKRETLDGEEEEQMDQ
2) VDEVTEDEVAPLTISST
175
138
198
154