<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27571

Description CBN-DPY-22 protein
SequenceMEPSNNDQAGPSRTPPPVLEEDRVVEKGVGSWFDGQPGQRMLRKANARMGTADVYIQSRDSEEDKLTPDRLKSGYMVPITPHEHQSLVFNAFENKLTRLERAPKKSFSMLASVIQKKGESSMNYDRDLKANRNGLPRFAVFNYKRILEDRCKFFSALSRGVSLDSLKMKIPSYRRKEFLFWEFFDYKIPYARAAWVTKFCGILNFHNASNSKKKSLLDVATLEMSQSSNRFIVYMVSKLYKVEEDDAAFKELMDMWDYSSGLILYMFHDGIMDKNEFLMDLTETFNVFFIRRHLQKPRILEKFALFYINFIEDISSSLIICRRTSTLLSQAMLMISEGSDLKRKFEAYKKGHIDECNQFEEWQMERTLFEMADIPIDQQPKTREERKKFYIKFFREMEEEPYFEEVPDQSMESHVLDHIEKELAAKKLFKMREKSKILKSIVKTEPDDMDTAGPSKSPEKAEDDSSSNSSDYEEITDGEMNWDGAASPATSTASNETSELVEDDATSSAQGTPGATPRKSPEATPVPDYDSDVTLTSDSSDGSSDSSRSSSPVKGSPIPLKPLHSPKEESPKQDFKYLRVGQKSQTASEMVSAGRYGDMTFPLWYQDGGVAVDPNYEDVLDFRNPTPPPMPAIDPIAVSSPTPSSTPSTPSATDLSGPQNEKDDSQEKETPERNSQDAEMAGTPQKDAEDPEASAEEDATPASEEDVLVDPRESQEAFEKLLSALEKDTKALSTDDDDSTDKSPNTPISDAAAMPPPALKPIEERSIDSAPRSVDAEPTESSPKSSDAPVAVEDEVMEVDKPEDVSARLNDSDVMIVEPPQNQHVDDGDVMVVAVVDARKEPEADEASEMKKELEELVEENMELVKHKLKFNEKWQTGPFHPGFMEWASSDERQRPLLLLSSMLQYLASVTPDSFVWNNLVVTKKERRHKMLPQLCGSPLDYLPCELHELPTLEGNEDMIESLRTRHLEIIRRSQAAEDKWIPAEAQVLKFDNIITTCVAIIGTMDSIDVEKKDAIQDAATRLFDFSEMSEQTAKREAQLRTKLMFKWCITEEREGSFRPVYVAKILRAAMDKSPDKKIGGWQVMDLVFNFMASEGPKHGRKMYQETFDACASLLIEMLHEKIFSHTEILQDLEKDLEIDYTNPLMSRQRKQKIPKPPRQPVQEPDESKLIQRPKKAITPKRLFMGKRMDLLERMLLVIPQVNVENSDEIRIRKTLLFGLHPADNFFFLQIRGIIKALSREFETKMYIQFNRSRHETSTTKKIRQPQLDEILRLFRAQTYNDQHIILERVVSHFIDGIGNFLSKGHDKVPAPEVANILCEMYEYSMDISSIFDFFEKIVPFLRDVDNKINTNRMDVIPDMYYTEVAFIFVSFFTKHFQRFILHERACSIVNQLWFLVHDMTTAEGYTVTCWGKVVATFIFFVRKTITEAGLVTEPFTAQDYQFLKIFPKPHTDELHTSCYNHDFPGNKLKIKASFLRYESFNDFKWIVANMSVNKKKKNGPRFTNCRYSFVVTAFKEACNHGRNFDRINELANYCANVTANDPPLVEYWLAGIRGLCFLGVDNGYAFKEMAQTIDISDCSTHYALSTFVLCLAGKGAFCIRRLLFDLAKFIFPLIHGPPPPPPSHQKSKKKSSKHPESPSSGEPGVCLALLIICGLMCGCDEPIAFSAHYKGVEVKKKRFANTADERIMNMFHWLELGESMFRLMCQLAQLLEALQSKSKDENLVLPKKFAVKDPLAEEDHREKAPYRPEFLFNIAKAVFLKICEQDWVTLRMFQYARMGAFNQVSMKTNCRGQLISRIATRRRTETENVPKLYEAHQISKKATIATVLDFMTLWNFRATLFDLNLMVTQISPEPNSRNLHHSALSADALTTEIGKAFKDMFANAYHAKINMPIVKPFEEFRLSDVNKYWLLAPLANNCTQPKNIPPQYPNGTVATKFLREVALLMETTPTTARQSLLQCSWALSRVPFINMVVSCLRIESGQQSKETFLQALYQQIQREVVRCHTRKAKLPYRMEHRECTILRMGLISHIYKEILKPSHVEAWGTLLFQVLFHGIINPDRERLIYDNTYDMLQNMILWTLVDGDTMNHNDRYGSYRARWPQYAGLIRKMRKVSNDKIKDTALQKFLPIGKCQLPTVTFKKYTTRTRNPAIVRRFVPGDGLKKGRYVYLPDAKTKTNTFDMAPEMTEGLQKGGWKYSMFQATRMDAVGKVVPNVLRTIIPHEHMQHFNKQSLVMSDAILSDSFLAAPEIEVTETLPEEAPVEEEEAVEETAVEKPMEPVAARALEAEKIAEVMPERAAEKEAEKEKPVEEMVSTPDTSSIVAPEVMEEATPPAAPLAPPTRGRGRKRTSGTARQPAGTRAKRTKSKVDVNDGGANLAPGSDIAPVVSGSGGTSSVTYHTTSDETRTNLKNMLNRKRNSIADSAAAAAAVAAAASSSSAMAPPGPSAYSGYPGPSGTMPSGNPVMVPPHPSAPPPPYNATAGRPPMPMGNQPGAMFQPPTTADMTPEERKQRMEQQMYEKLAQQKQFMDQQARMREQRERETKEHEERRAREEEQKRLDRLRAIEESNAIMERANRQREETRRQEETARRQEEARLQFEAEQQRLKQEREAEERRREQARQEQERQERMRREAEERARAEEQAKKEHEERVRREQERARWEAAEQARIAEEQRREYLRKEEEKRQEQMRLERERQEQERARAEAAAQREAEHRRMMEQQSRQMGQQAPPPPYNQQGQPPGYHQPSHGQQFMQQGQQLRQSPAFPQPQFGAPGFPQPGMPGTRLMPGKPDQAHAQQYQHTQNQAAISQKEKEKQYLQAKNLQAAAAGGQQQRFGDASSSFGRQQAPGAPGTMMGQPGPTQAAQSAQQRQTMQPNMGQQAQNRGQNAPGYQQQVQSGYQQQAMGQVPAQNQTPGQFGRDAAYQQQQQQQANQWSAQAQNQMSQQGQQQAQAQAQQFGRTTGQGQMGNQGPQQPQQQQRMVGMGQPGMTQAAMGQQAQMGQQRGAQPGMAQPGMAQPGMAQPGMARSGQQQQQMPQQQAQQQAQQQAQQQVQQQARQMSQMGAMGMGGQPGMGGHMGQQPQMGQPGMGGRQPQQAPQQAQRQMNPMGQPGMGGQPQQAQAQRQMMGADQQAQLQAQEQYRRMQQMQQQQRMAQQQGGQPRGQAQQPMGGMGAMGAPQQQQQMQQQQQMQGGQQQRYPGQYLNYYQQQQPPQN
Length3208
PositionKinase
OrganismCaenorhabditis brenneri (Nematode worm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.07
Grand average of hydropathy-0.760
Instability index55.84
Isoelectric point6.45
Molecular weight364278.22
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27571
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     234.12|      20|      20|    3083|    3102|       1
---------------------------------------------------------------------------
 2917- 2939 (27.17/ 7.94)	AA.....YQQQQQQQANQwsaQAQNQMS
 2956- 2974 (29.38/ 9.29)	TT.....GQGQMGNQGPQ...QPQQQ.Q
 3056- 3076 (24.69/ 6.43)	QM.gamgMGG.QPGMGGH...MGQQ..P
 3077- 3100 (38.04/14.55)	QM.gqpgMGGRQPQQAPQ...QAQRQMN
 3101- 3120 (27.84/ 8.35)	PM.gqpgMGG.QPQQA.....QAQRQM.
 3140- 3164 (28.87/ 8.98)	QMqqqqrMAQQQGGQPRG...QAQQPMG
 3165- 3185 (32.80/11.37)	GM...gaMGAPQQQQQMQ...Q.QQQMQ
 3186- 3205 (25.32/ 6.82)	GG.....QQQRYPGQYLN...YYQQQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     395.21|      43|      44|    2577|    2619|       2
---------------------------------------------------------------------------
 2534- 2572 (44.20/14.54)	REQ...RERE...T.KEHEERRAR.EEEQ...............................KR......LDRLRAIEE.......SN......AI...MER
 2577- 2619 (68.07/26.59)	REE.TRRQEE...TARRQEEARLQFEAEQ...............................QR......LKQEREAEE.......RR......RE...QAR
 2646- 2677 (40.95/12.89)	HEErVRREQE...RARW.EAA................................................EQARIAEE.......QR......RE...YLR
 2678- 2727 (38.15/11.48)	KEE.EKRQEQmrlERERQEQERARAEAAA...............................Q...........REAEH.......RRmmeqqsRQmgqQAP
 2729- 2758 (39.86/12.34)	PPY.NQQGQP...PGYHQPSHGQQFMQQG...............................QQ......LRQ.............................
 2845- 2884 (46.33/15.61)	GAP.G........TMMGQPGPTQAAQSAQ...............................QRqtmqpnMGQQ..AQ.........N......RG...QNA
 2885- 2952 (31.99/ 8.37)	PGY..QQQVQ...SGYQQQAMGQVPAQNQtpgqfgrdaayqqqqqqqanqwsaqaqnqmsQQ......GQQQAQAQA.......QQ..............
 2981- 3017 (32.36/ 8.56)	.................QPGMTQAAMGQQ...............................AQ......MGQQRGAQPgmaqpgmAQ......PG...MAQ
 3018- 3052 (53.29/19.12)	PGM.ARSGQQ.......Q..QQMPQQQAQ...............................QQ......AQQ..QAQQ.......QV......QQ...QAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.68|      70|     372|     759|     829|       3
---------------------------------------------------------------------------
  759-  829 (111.98/63.19)	LKPIE.ERSIDSAPRSVDAEPTESSPKSSDAPVAVEDEVMEVDKPED........VSARLNDSDVMIVEPPQnQHVDDGD
 1130- 1208 (107.70/56.79)	LQDLEkDLEIDYTNPLMSRQRKQKIPKPPRQPVQEPDESKLIQRPKKaitpkrlfMGKRMDLLERMLLVIPQ.VNVENSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.51|      23|      23|    2451|    2473|       4
---------------------------------------------------------------------------
 2422- 2444 (32.01/12.18)	SAAA......AA.AVAAAASSS.S.AMAPPGP
 2445- 2469 (39.10/16.66)	SA....ysgyPG.PSGTMPSGN.P.VMVPPHP
 2470- 2499 (24.40/ 7.38)	SAPPppynatAGrPP..MPMGNqPgAMFQPPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.45|      21|      21|    2260|    2280|       8
---------------------------------------------------------------------------
 2260- 2280 (35.56/17.62)	PVEEEEAVEETAVEKPMEPVA
 2282- 2302 (29.89/13.53)	RALEAEKIAEVMPERAAEKEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.88|      12|      25|    2157|    2168|      19
---------------------------------------------------------------------------
 2157- 2168 (24.24/15.78)	P..GDGLKKGRYVY
 2183- 2196 (20.64/12.07)	PemTEGLQKGGWKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.26|      11|      20|    2793|    2803|      21
---------------------------------------------------------------------------
 2793- 2803 (22.06/14.30)	QQYQHTQN.QAA
 2811- 2822 (15.20/ 6.95)	KQYLQAKNlQAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     199.00|      70|    1629|     672|     752|      22
---------------------------------------------------------------------------
  672-  752 (102.32/89.18)	ERNSQDAEMAGTPQKDA.EDPEasAEEDATPASeedvlvdPRESQEafEKLLSALEKD...TKALSTDDD.DSTDKSPN.TPISDAA
 2303- 2383 (96.68/59.95)	EKEKPVEEMVSTPDTSSiVAPE..VMEEATPPA..aplapPTRGRG..RKRTSGTARQpagTRAKRTKSKvDVNDGGANlAPGSDIA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27571 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IEVTETLPEEAPVEEEEAVEETAVEKPMEPVAARALEAEKIAEVMPERAAEKEAEKEKPVEEMVSTPDTSSIVAPEVMEEATPPAAPLAPPTRGRGRKRTSGTARQPAGTRAKRTKSKVDVNDGGANLAPGSDIAPVVSGSGGTSSVTYHTTSDETRTNLKNMLNRKRNSIADSAAAAAAVAAAASSSSAMAPPGPSAYSGYPGPSGTMPSGNPVMVPPHPSAPPPPYNATAGRPPMPMGNQPGAMFQPPTTADMTPEERKQRMEQQMYEKLAQQKQFMDQQARMREQRERETKEHEERRAREEEQKRLDRLRAIEESNAIMERANRQREETRRQEETARRQEEARLQFEAEQQRLKQEREAEERRREQARQEQERQERMRREAEERARAEEQAKKEHEERVRREQERARWEAAEQARIAEEQRREYLRKEEEKRQEQMRLERERQEQERARAEAAAQREAEHRRMMEQQSRQMGQQAPPPPYNQQGQPPGYHQPSHGQQFMQQGQQLRQSPAFPQPQFGAPGFPQPGMPGTRLMPGKPDQAHAQQYQHTQNQAAISQKEKEKQYLQAKNLQAAAAGGQQQRFGDASSSFGRQQAPGAPGTMMGQPGPTQAAQSAQQRQTMQPNMGQQAQNRGQNAPGYQQQVQSGYQQQAMGQVPAQNQTPGQFGRDAAYQQQQQQQANQWSAQAQNQMSQQGQQQAQAQAQQFGRTTGQGQMGNQGPQQPQQQQRMVGMGQPGMTQAAMGQQAQMGQQRGAQPGMAQPGMAQPGMAQPGMARSGQQQQQMPQQQAQQQAQQQAQQQVQQQARQMSQMGAMGMGGQPGMGGHMGQQPQMGQPGMGGRQPQQAPQQAQRQMNPMGQPGMGGQPQQAQAQRQMMGADQQAQLQAQEQYRRMQQMQQQQRMAQQQGGQPRGQAQQPMGGMGAMGAPQQQQQMQQQQQMQGGQQQRYPGQYLNYYQQQQPPQN
2) KSIVKTEPDDMDTAGPSKSPEKAEDDSSSNSSDYEEITDGEMNWDGAASPATSTASNETSELVEDDATSSAQGTPGATPRKSPEATPVPDYDSDVTLTSDSSDGSSDSSRSSSPVKGSPIPLKPLHSPKEESPKQDFKYLRVGQKSQTASEMVSAGRYGDMTFPLWYQDGGVAVDPNYEDVLDFRNPTPPPMPAIDPIAVSSPTPSSTPSTPSATDLSGPQNEKDDSQEKETPERNSQDAEMAGTPQKDAEDPEASAEEDATPASEEDVLVDPRESQEAFEKLLSALEKDTKALSTDDDDSTDKSPNTPISDAAAMPPPALKPIEERSIDSAPRSVDAEPTESSPKSSDAPVAVEDEVMEVDKPEDVSARLNDSDVMIVEPPQNQHVDDGDVMVVAVVDARKEPEADEASEMKKELEELV
3) MEPSNNDQAGPSRTPPPVLEEDRVVEKGVGSWF
2249
439
1
3208
858
33










Molecular Recognition Features






MoRF SequenceStartStop




1) AFEKLLSALE
2) FPLWYQ
3) KQDFKYLRVG
4) QQMQQQQQMQGGQQQRYPGQYLNYYQQQQPPQN
5) YEDVL
717
601
572
3176
616
726
606
581
3208
620