<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27567

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEHQKDARLQDLKKDRSNAQGGDALHTQDAFNGQNSASQKAAANGQVTTSEATGLPTPPELDQSWRDGPDNKPMGVLIERLAQQCFTDLGTTLKTMAEIPESTQANGVVPHAVDTSVASLTKKRTLMDFAHNQRDRFIKTLVLSDWARNEQDMARLVDIKVWQERQLGAQVQAISSIGNTKHNMQGAKIPNPNLDGALELLATGTSRMPDLGYLPPKKLSAKQLLRTLQDMNVALATRLNLHEELPYYFNDLSIANGRATFRVADEFEVDLSLGDEDPSTPFWFIDMRFLFSPTPDITDDVSRMELEKRVNIALASESKLQGCYDLLHNFVLTHKINVLRDQASQLLREKWFDCLFVEMKKRVLIVQYWSDLAGPKSWLEIGVSTGKQNRKGSKPANAQLSVRWFRRGQEVLDDSPSIDWKTLNVEQVLGTLIAKHTSWDLRNTKNGLVKLAGSNSKLDMTLDACADTPEDCSLALGLPGMRTPYIVRKEVVTGKWAISPPTMLAARAERLMNADLKADPAVQLAQMLCGTNQERIGKAADLAGWISVSSRTLAPQNNLKALFGADTVSRSIYKCKRGWSDSWALVATFGLSGDKWWAARLEPKLEARGTSTGSIFAEARRISIPSDLLALSGVARSLLIRIEKLAVAQISLAVVTQDLDSKRIPYKIENTASLTPAERSRGERSSAASAEPAVVLDSASFFDDAKSDPLRKPFKDGSIRLTHDRNITSPPATDGSRAEVTHCLRLTVRHGVLNHLQEYLLTKPRDADMFMNDRGALALRVRVQFGQPCVSVLQARLRSCKRLDAYLVALARYSFVCTHLSLTRVTFTYPSNPDLSATVRFSTNPNAPPSADLKLHPTDSNPHQRVRVIALRTFNLAPLDPKSFTALLYTLRTSVSLNIAYSTISALPPLGSMHIHPHHLLAYLWTYSAPLPGAGAQFKIQWRPNVGEKKKGVWHIMTQLSKPNKGSGELREEVRMGIAEVCLKKGSGRIGNGTSIVVEDGLVGEVIRELDRVCREGGEAVDGKKEEEVKDVKVDTAAGSRPSVATQRTGSSTSVKTQGWQQKTAQMKSGGHAGLQQANGSGNGNGHRGSVTNGNGNANGNGRLKQEIIELD
Length1112
PositionTail
OrganismZymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.06
Grand average of hydropathy-0.378
Instability index32.85
Isoelectric point9.19
Molecular weight122205.65
Publications
PubMed=21695235

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27567
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.46|      26|      33|     919|     951|       1
---------------------------------------------------------------------------
  919-  948 (39.87/41.18)	HLLAYLwtySAPLPGAGaQFKIQWRPNVGE
  955-  980 (43.58/21.90)	HIMTQL...SKPNKGSG.ELREEVRMGIAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.87|      13|      16|     126|     138|       4
---------------------------------------------------------------------------
  126-  138 (25.30/14.65)	LMDFAHNQRD..RFI
  143-  157 (19.58/ 9.81)	LSDWARNEQDmaRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.36|      33|      33|     719|     751|       5
---------------------------------------------------------------------------
  719-  751 (56.94/37.06)	IRLTHDRNITSPPATDGSRAE.VTHCLRLTVRHG
  753-  786 (51.41/32.72)	LNHLQEYLLTKPRDADMFMNDrGALALRVRVQFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.11|      47|      50|     305|     352|       6
---------------------------------------------------------------------------
  305-  352 (76.84/47.27)	ELEKRVNIALASeSKLQGCYDLLHNFVLTHKINVL.RDQASQLLREKWF
  358-  405 (80.27/45.60)	EMKKRVLIVQYW.SDLAGPKSWLEIGVSTGKQNRKgSKPANAQLSVRWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.88|      13|      16|     420|     432|       7
---------------------------------------------------------------------------
  420-  432 (22.17/16.05)	WKTLNVEQVLGTL
  439-  451 (22.72/16.65)	WDLRNTKNGLVKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.93|      58|     111|     465|     540|       8
---------------------------------------------------------------------------
  465-  540 (87.03/85.82)	CADTPEDC.SL..ALGLPGMRTpyivrkevvtgkWAISPPTMLAAR..........AERL.MNADLKADPAVQlAQMLCgtnqeRIGKAA
  575-  646 (80.90/46.82)	CKRGWSDSwALvaTFGLSGDKW............WAARLEPKLEARgtstgsifaeARRIsIPSDLLALSGVA.RSLLI.....RIEKLA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27567 with Med14 domain of Kingdom Fungi
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