Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MDDNFIHRYMAESLFFDHSTNNGFFIAQAQTDRYMWETSLKRKEFEALLRNKAGTEYMIVGEPQPVADKTLAAQGVKTGIYVVRKQERQSVKDKSQRSYAPGVSHEGNWELTTLATYFIVGEQIYQAPSVFDVVGNRLLSAASSLNKAVEIANDLPRYTPATGYHYLPQTVKRAANTAGSVAGSPVGSREGSVVPGVDSQSVRSGSILADTSLPAAAPTTSFQETRLLRDSLRLAFQHGDEYTDENPLSGEPGSLKFATSNAAVKKRRADEEAAVAKARAEKESATTSRAVSPKVEKVPSPPAVFTEAKTTVKSEKSGKHKNGDKIKRRKSRVNGTATSPTTPASATSANAPNSAI |
Length | 356 |
Position | Head |
Organism | Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.556 |
Instability index | 49.46 |
Isoelectric point | 9.45 |
Molecular weight | 38475.51 |
Publications | PubMed=21695235 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP27565 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 104.51| 37| 59| 155| 192| 1 --------------------------------------------------------------------------- 155- 212 (49.58/34.09) LPRYTPATGYH...YLPQTVkRAANTAGS..VAGSPVGSREGsvvpgvdsqsvrsgsiladtS 213- 254 (54.93/33.62) LPAAAPTTSFQetrLLRDSL.RLAFQHGDeyTDENPLSGEPG....................S --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EKSGKHKNGDKIKRRKSRVN 2) FIHRY | 315 5 | 334 9 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab