<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27562
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MALPPEHFKALDQLRLRLSQLSTSIGLLRNELEREQPLPTCLGSNLQNLAATLSSQRQLFSSEHAYPLPDFPGHTQEGLLQQLLRKKLDPKAEAWISESLEGDKKTQNGTAEEEATLSSEDTMALWSWAGNAIGEMRTEMEDSGAFRDDYTLAERQAGISSVVTGIRRKLGRDMDSEDEDDDEDDDGNMDTKDEELKDGHEADASPSQSASLEGFNPTAPPIPLDTLLRFATGSNPLQAGSDIQTLTTSPAATSTSTALSPCHLHTMAMAPPPAPSPRAGRRRAFPLEMLPAELRDLIYSFTIADKLEPWPLAKCRKRGWYFKANSHIIPVNLLCVSHRIRQEVTTVMHSHALFIVEHLPIFDRLVQSRPLGSSLRRLSIGLSHEGFFRLFGHSFRDGDIEEGWFGNSSSHFTPSPRPTVQFLQHMDLKQLVLVISPPPRSGEYPYTVCQRSIVDKIFEEAFPWVSGLPVTVMGWVMQYQKEEFEAKCTRARQQYLKWYEDWAYEGETTPLVSYHEWEDDDGGVSLVPSVGNEESEVLEEFPPRCACEHSCDYDLWSPWTKGHENEGVV |
Length | 569 |
Position | Head |
Organism | Zymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes>
Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.518 |
Instability index | 54.45 |
Isoelectric point | 4.91 |
Molecular weight | 63912.84 |
Publications | PubMed=21695235
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP27562
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.71| 20| 55| 482| 502| 1
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482- 502 (35.20/24.26) EEFEAKCTRARQ.QYLKWyEDW
539- 559 (39.51/22.31) EEFPPRCACEHScDYDLW.SPW
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 148.15| 46| 55| 27| 73| 2
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27- 73 (75.63/44.38) LLRNELE..REQPLPTCLGSNLQNLAATlSSQRQLFSSEHAYPLPDFPG
83- 130 (72.53/38.76) LLRKKLDpkAEAWISESLEGDKKTQNGT.AEEEATLSSEDTMALWSWAG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 53.56| 15| 56| 303| 318| 3
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269- 283 (29.96/16.09) MAPPPAPSPRAG.RRR
303- 318 (23.61/17.06) IADKLEPWPLAKcRKR
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