<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27561

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAPFKRSRPMRVLALGMSRTGTQSVSNALSQLGYDRVYHGHDMGDDAASVYTWRDLWRRKQQHGSARITSQDFDQVLGVCEAVTDAPSVLFWSELMDAYPDATIVLVIRDTEKWYGSFSSVCIDPYCSKRSRLVQSGVRLRLFPYNVLAFLPEMFMGYFQAKTEEQFRSNARVIYEQHNASIVARAENEGRPLLQMRLEDGYEPLCKFLDKSVPDAAFPRGNDAASLRSKTLRDERAGSTQKPKEARKAVSHLRREKVLCAIVEQDIYIFGDVNPEHTLELENTYDLVEEGTVCSQDETISVDTKDIFLDAVEHAIAFSLAVDPAITYVAPWTWLYHDSEAENGSDADSGSIIKMYAEYTPTAALLLVPEILPASWLPIGHADAQVGSHIILAPRGIPARRIAEARRRVSPDNAWKAKVSEVLQLDAIQTDDDTVWISVELQDSAGLCCLWPAELCLAPFTATNLDFCATTRQSDWRRWLVGLEEEDAFRNPLAVAEEWFKGAGEREQAVQNAVKASTGDPHSSQNLVSTAANDEEAMTSPPFMQRALDQQTAVSGIYPTPPDGMAQAPQTAQINLGATPSVAHTDNTMSGVEMTSNTNDHAQSNGSDPDQSLDREDFELNQEDLFGDNSGGVEFGEDAVDDADFNFFDEPDDEPEQGTVASTEMDDESTHEHELDPVIAQDTVTESQAALDDIPAATAVDSAVSENLTLPTCNDIAGDVILAVGSDDSRFATHTSEPEKALSPFGIRERLLPPPVPASLANTDSKDSAKYRKHSTFAPIVFKDSFNLGPKYADTRLEDDEAQRPIVKSKVPNINLPPVKKKSRLLRQKADMEYRMTDPNSESEEDSYESASSDSDDELPPKLPWDTRKRKRPSDDDRLQPLASSMERMLSDDDPGDDSEATESQHDADTMLEKCLPRASSGGISVSFKNPFDNYSGCGPKNASGEESGDSIRNVEELFSLRKEDLIYVAQIVHEQAMSMSRSSVAEQDLFSNGGPDPEKAQCGRMSIAKAVESVFPDFEICDLVQLAATRDQAPRLTVPVKTPQGQPRMPQRSDSQIVLGPDYFPLPSPYVRIQRGADDWEMTSTCLSFWETLGLGPTNGPKNVRAFCVFPFNEDLQHLVEQFMGDLGTSYENCKLGSYVHLRNVSDASLDSFEDGMAPVEVNEEGDSVEGLLKAYATTCAELGKVLSTIGHEESDRTIVVYMLNPFSGRQALQHLCACFWVLFKAYRDNVPKALRNQCGSDIVLQVLPMKLVASFDELVMPEAKEMALLAREVYDRCPPSSSHNSETLSALPILAAPSVELANAAPKRIAFQLAAEPPSDLLHEGSILHLAYACSQDGHWLTVAWIDNTGQHQSTASFCLRGKTFSEVAEDVWGRTREILAARQVTWRVFIVTPDAMDTSLSQCWRSITSRRRPHPLCVTLLSVQLDPILHLSPPAPPSDTQITWPTADGGFLTPASTPQAGNLTSSPNPGGDSTAPPTPAPSETMTAASIAENDPDAYLTDLTDETWGVLLSPKLAPFASSFPGQANGALFRRGDPSPGEALPSLGVSVHWTIQVKPSGGVDDGSVKQAELTCREVLKMYRGLSVLTKARGLDGGRRGTEWVTPVHVAMVVRGVEGLEGFLEKGGET
Length1631
PositionKinase
OrganismZymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.07
Grand average of hydropathy-0.402
Instability index47.85
Isoelectric point4.66
Molecular weight178932.71
Publications
PubMed=21695235

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27561
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     715.39|     226|     875|     423|     666|       1
---------------------------------------------------------------------------
  423-  666 (353.26/241.79)	VLQLdAIQTDDDTVWISVELQDSAGLcCLWPAELCL..APFTATNLDFCATT......RQSDWRRWLVGleeEDAFRNPLavAEEWfKGAGEREQAVQNAVK.ASTG.DPhsSQNLVSTAANDEEAMTSPP....FMQRALDQQTavSGIYPTP.PDGMAQAPQT.AQINLGATPSVAHTDNTMSGVEMTSNTNDHAQSNGSDPDQSldreDFElNQED..LF..GDNSGGVEFGEDAVdDADFNFFDEPDDEPEQGTVASTEM
 1330- 1575 (362.13/200.92)	ILHL.AYACSQDGHWLTVAWIDNTGQ.HQSTASFCLrgKTFSEVAEDVWGRTreilaaRQVTWRVFIVT...PDAMDTSL..SQCW.RSITSRRRPHPLCVTlLSVQlDP..ILHLSPPAPPSDTQITWPTadggFLTPASTPQA..GNLTSSPnPGGDSTAPPTpAPSETMTAASIAENDPDAYLTDLTDETWGVLLSPKLAPFAS....SFP.GQANgaLFrrGDPSPGEALPSLGV.SVHWTIQVKPSGGVDDGSVKQAEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.58|      50|      55|     825|     877|       2
---------------------------------------------------------------------------
  825-  877 (82.12/58.49)	RLLRQKADMEYRMTD..PNSESEedSYESaSSDSDDELPPKLPWDTRKR.....KRPSDD
  879-  935 (79.46/46.69)	RLQPLASSMERMLSDddPGDDSE..ATES.QHDADTMLEKCLPRASSGGisvsfKNPFDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.32|      25|      60|     731|     757|       3
---------------------------------------------------------------------------
  731-  757 (36.74/24.23)	RFATHTSEPEKALSPFgIRERLlP....PPV
  792-  820 (38.58/17.57)	KYADTRLEDDEAQRPI.VKSKV.PninlPPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     477.65|     135|     874|     119|     266|       4
---------------------------------------------------------------------------
  119-  266 (213.04/125.54)	FSSVCIDPYCSkrsrlvQSGvRLRL.......FPYNVLAFLPEMfmgyfqAKTEEQF.RSNARVIYEQHNASIVARAENEGRPLLQMRLEDGYEPLCKFL..DKSVPDAAFPRGNDAASLRSKTL...RDERAGSTQKPKEARKAVSHLRREKVLCAIVEQ
  346-  411 (62.09/22.64)	............................................................................SDADSGSIIKMYAE..YTPTAALLlvPEILPASWLPIGHADAQVGSHII...LAPRGIPARRIAEARRRVS..............
  992- 1124 (202.52/98.14)	FSNGGPDPEKA......QCG.RMSIakavesvFPDFEICDLVQL......AATRDQApRLTVPVKTPQGQPRMPQRSDS......QIVLGPDYFPL........PSPYVRIQRGADDWEMTSTCLsfwETLGLGPTNGPKNVR.AFCVFPFNEDLQHLVEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.67|      27|    1150|      41|      67|       5
---------------------------------------------------------------------------
   41-   67 (52.25/32.02)	GHDMGDDAASVYTWRDLWRRKQ.QHGSA
 1193- 1220 (45.43/26.86)	GHEESDRTIVVYMLNPFSGRQAlQHLCA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27561 with Med13 domain of Kingdom Fungi
Unable to open file!