<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27560

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASAPLSFKPWSLQPNNETSLQDVLARVGNERGAFRDISEASLRDEIANGVSTPSSSESSDDEDDNDALSRPSRPKATTRQELFAARAEMLSEVQSAQNEILLALDFVSLLESSHAPQQAGVTVSQALKAVAPLGTLGTDIWHRMPENRAREGQDNLLATKVRMQTLQKSADDLLAAAGRLEDNVRRETIFWDQVLAISERGWSVSRIPRTQGVLGVHFGFNGSAGEFARRDLAALLPGEDGGIALERGVGTKPKGIKVVVKRDGRVVGSSRLPTMPDEEETTLEARIRHARDSLYDEELFHEMVREARTLTSMGVEMRSSTLSFMPASNASLRIELELVLLEDAKQLEDNTLHHSDDLAQATLLAARLLLGQAHREKIKQKTEPPPPMSDRKDKPPILAIIRPILLVFTHHTLCQRLNAYATNIETLLGNADINATIEPANFTFSLPNDLSSTTSESIINAIFLRPLTATASITVPTPSDETEDFRLDLSIETLSAISLGSAFSIRLPSASAAAAVGTPQAFTLSAIEDLFSTADEMLATQMLEVLYPHADPAKAWSLIPAEGKLCRNVGDEEDGAQEEVRLDIDGEVGEMDLVFVASDGRETRKGGWKVDKEDLLRNDKSLWEVWKDVVGVDGGEGEDEQEQEVEV
Length648
PositionHead
OrganismZymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.05
Grand average of hydropathy-0.326
Instability index43.26
Isoelectric point4.71
Molecular weight70838.62
Publications
PubMed=21695235

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27560
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.48|      37|      44|     439|     477|       1
---------------------------------------------------------------------------
  439-  475 (61.27/35.33)	EPANFTFSLPNDLSSTTSESIINAIFLRPLTATASIT
  482-  518 (54.22/32.53)	ETEDFRLDLSIETLSAISLGSAFSIRLPSASAAAAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.02|      28|      44|      10|      37|       2
---------------------------------------------------------------------------
   10-   37 (48.47/29.47)	PWSLQPNNETSLQDVLARVGNERGAFRD
   54-   81 (46.55/28.02)	PSSSESSDDEDDNDALSRPSRPKATTRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.11|      11|      15|     155|     165|       4
---------------------------------------------------------------------------
  155-  165 (19.04/12.02)	DNLLATKVRMQ
  172-  182 (18.07/11.03)	DDLLAAAGRLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.37|      13|      15|     280|     292|       5
---------------------------------------------------------------------------
  280-  292 (21.10/14.00)	EETTLEARIRHAR
  297-  309 (22.27/15.17)	DEELFHEMVREAR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27560 with Med17 domain of Kingdom Fungi
Unable to open file!