<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27558

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDSNQIEEASMVDAAMMDPTMEDLFGEAANDLAVGDLGVGLPPIPLPPSLMLRIAELQHKGCCTMVPAEGNISNDITRNELHAVVGMHWLAGPYIRPANKIGNKWEAQLQQRDQHSIKIHHPAMGRHAVLYITRSTELTLLYQNEGQGWQSTSIVIDEVRSSDQIISHAAMGEEGADLLVVTFDHSSRMRLYRVSIEWNATQHSRQAGMVYTLIAPTMEVHHLTASHHTRAQHAHSAQLTHLEIIPAVPEAAQTMPTAATILAVFTQTSVPSDANPSQNAYSIISRWRVESLMPTLHDSFKKLSNARADSNGVLNPTTVLRRESDIITNKPILSIKSQMFDTMLAFTSSDGSIDLRDRLTMDQLGPFGLPTTVSSLLQAGFDHIASTQNLHVALSADASGLATISASDNSLTARPMTFTHGWTPSTPSALLDNTPYLEAGTVCLARQYAFLCYNSMSNDEVLSLFPSPAPDPSLHTTFLTQIFKMVNRSPDISMHENARQQMAVLKEPIVPRVLSAQLSLGTEPITGNRNVAAQYAYIFLNLRHIGTALAHTISQKDLSRVSPEAVHSLRPLVRWSIDLMIHIVSALSQLRGSNPSTTSASPILPLLLASFSRALLRFQVLWVIKYLHLLQQIIPRLPTLAQRTELAATLELGTKSLPFKLPALEALLVDVDSAIRQVYSSGEVNAERRGEIEVGLICGRGEVPRELQAVVARLVDVGVGKVLDVEGTDVVKLCFWDTTWLGIERVQTPPPRSSHTNGTHTSKTSPTEAVFPGDMEIGGRWGYDIIRKVPLTEGMVVRECRRCGAVMEDFSPERVRASPGWLGHAQKNCVCMNYWVCG
Length838
PositionTail
OrganismZymoseptoria tritici (strain CBS 115943 / IPO323) (Speckled leaf blotch fungus) (Septoria tritici)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Zymoseptoria.
Aromaticity0.06
Grand average of hydropathy-0.077
Instability index47.20
Isoelectric point6.17
Molecular weight92034.26
Publications
PubMed=21695235

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27558
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     759.70|     194|     195|     213|     407|       1
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   16-  130 (107.95/65.32)	.................................................................................................MMD.PTME.........D...LFGEAANDLAVGDL..GVgLPPIPLP...PSLMLRIAELQHKGCCTMVPAEG.NIS......NDItrnelHAVVGmHWLAGPYIrP..AnkIGNKWEAQLQQRDQHSIKIHHPAMGRHAVL
  131-  325 (283.97/186.75)	YITRSTELTLLYQ..NEGQGW....QSTSIVIDeVRssDQiISHAAMGEEG.....ADLLVVTFD...HSSRMRLYRVSIEW.NATQHSRQAGMvytLIA.PTMEVHH.LTASHH...TRAQHAHSAQLTHL..EI.IPAVPEA...AQTMPTAATILAVFTQTSVPSDA.NPS......QNA.....YSIIS.RWRVESLM.P..T..LHDSFKKLSNARADSNGVLNPTTVLRRESD
  326-  516 (241.47/162.34)	IITNKPILSIKSQMFDTMLAF....TSSDGSID.LR..DR.LTMDQLGPFGLpTTVSSLLQAGFD...HIASTQNLHVALSA.DASGLATISASdnsLTA.RPMTFTHgWTPSTP...S.ALLDNTPYLEAG..TV.CLARQYAflcYNSM.SNDEVLSLF.....PSPApDPSlhttflTQI.....FKMVN.RS.......PdiS..MHE......NAR.QQMAVLKEPIVPRVLSA
  525-  658 (126.31/78.23)	ITGNRNVAAQYAYIF...LNLrhigTALAHTIS.QK..D....LSRVSPEAV.HSLRPLVRWSIDlmiHIVS......ALSQlRGSNPSTTSA.......sPILPL...LLASFSralLRFQVLWVIKYLHLlqQI.IPRLPTL...AQRTELAAT.LELGTK.SLP........................................................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27558 with Med16 domain of Kingdom Fungi
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