<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27549

Description Uncharacterized protein
SequenceMGAHPRPPQRSVSSSSLPVQRPPPQRSLSHQQQFMAAASPVRKDAPFIDLTADAGDATPNRYHTTPRRGGSRLRLELSHNASSSSLPTSESPQSLTPSRIPNSDPFQAMVGSPAGSASSTLMPMPTRRPVTSQPRFAPRITATAPAPAKKDARPKPYTVEIPSVAPRYFSANRPETAVRNPVDPFSKGLNSGYADFFPWNGAHHEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLNALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVAGFGENDWKNRVTYALQSRIPMWLLIAQIYWKDLLRSRKYGRRLVFALLSHLHVISNDPDQDLLVQLSSRLSALLGSLIRSNPESFINPGAWSTYKDTLHACLRSDDEQARKALHAINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESSDNHLAAACWATSENKSLIMKTVVEWATSFHRPGLAKVYAATRLIRQWSQFRVNPTTPILETLDNIAANDKARKNLVYHLVTELVRTGHFSVSQYMQWTIARGGYHCAAEIDPVSGPCSSRLLVELPLHALSEKRRAERGNLLRRAGNYSVAEEDQDITNAIRVVKHVVGLPLLSDDPLSGRKPMSLKKLLQRMGGSSTALRSSIGAHLRDELTGQFIMKGHSLSLTMFTAVRDIMEMAEDYAMLSDILGACAKTADSDVLASVADTVHSNLQIFCALDSANELFNSLIERLRMMNEEQRLVPRPLLAALSSLAQRMAGHEVIASQLRQELVQNDRNNAIDACSPVSDIVATPSHQAENNVAEEVERTLSSGTRLDPPTMNKLFRMIIPALERGWEKEDDTRRVFATLLARIRVFDAHHFDKLMTDWTSHIRSISNRSSLSTLFPLLIITGCLTMPIIMSTASPPFANIQNLAPESSRGPATYLQELLQLVIMPLPQATGLVAEESYRFHTEQKCAKFEQSKGLLNLVRNALLEYSTVRNHVNGTEFPLDNLECQESLLETLRTLVLVDSSAVSNALGIKSLPAEAVGLVRKVTTKLLIPGDSGETQISFDHILQIANELTLPFCQLKLNLDLSLPQPSVIEGQDQSSSRFEIFARAMDRAIEAGNIMWTSLLPCLSDDITQHLKTQAQTGFLDLIPSSKAPEFVDTGSRQSLRMAENLLEVVEAIISGQAPPKMAQLSLGMVEKLTDLWEIVAAGPQERPNCHAAVLQHWLPAMLRFVNLHSLSSEPPSAPLPTASATRPPIPPVHDVRARIVLVLCGLLLELETLPPATVGSLVQQVFDIAILLVDALPEELRANCARATLLTPGGMPNQGTSSDPRLYYLFSSPPPSPSDNLMLSHREKAATPQSAAARGMGAQYGIGPVVQERLSPFILRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1490
PositionKinase
OrganismFusarium oxysporum (strain Fo5176) (Fusarium vascular wilt)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.06
Grand average of hydropathy-0.199
Instability index52.64
Isoelectric point8.90
Molecular weight163972.00
Publications
PubMed=21942452

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27549
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.76|      59|     101|     772|     834|       1
---------------------------------------------------------------------------
  772-  834 (94.11/71.86)	SDILGACAKTADSDVLASVADTVHSNLQifcaLD..SANELFNSLIERL.RMMNEEQ..RLVPRPLLA
  873-  936 (87.66/56.61)	SDIVATPSHQAENNVAEEVERTLSSGTR....LDppTMNKLFRMIIPALeRGWEKEDdtRRVFATLLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     199.12|      52|      67|     638|     689|       2
---------------------------------------------------------------------------
  601-  628 (39.99/19.32)	...............NLVYHLVTE.........LVR..TGHFSVSQYMQ.WT..IA.R
  638-  689 (88.84/51.66)	DPVSG..PCSSRLLVELPLHALSEKRRAERGNLLRR..AGNYSVAEEDQDIT..NAIR
  703-  759 (70.28/39.37)	DPLSGrkPMSLKKLLQ.RMGGSSTALRSSIGAHLRDelTGQFIMKGHSLSLTmfTAVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.83|      11|      67|      13|      23|       3
---------------------------------------------------------------------------
   13-   23 (22.02/12.83)	SSSSLPVQRPP
   82-   92 (20.82/11.64)	SSSSLPTSESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.95|      54|      96|    1258|    1318|       4
---------------------------------------------------------------------------
 1258- 1318 (92.65/63.61)	PPKmaqlSLG.MVEKLTDL.WEIVAAGPQE.RPNCHAAVL..QHWLPAM.....LRfvnLHSLSSEPPSAP
 1354- 1417 (78.30/40.46)	PPA....TVGsLVQQVFDIaILLVDALPEElRANCARATLltPGGMPNQgtssdPR...LYYLFSSPPPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     157.54|      39|      86|      24|      67|       7
---------------------------------------------------------------------------
   24-   64 (67.84/43.26)	PQRSLSHQQQFMAAASPVrkDAPF.IDLTADA...GDATP.NRYHT
  128-  159 (39.39/19.28)	..RPVTSQPRF..........APR.ITATAPApakKDARP.KPYTV
  165-  203 (50.31/29.01)	APRYFSANRPETAVRNPV..D.PFsKGLNSGY...ADFFPwNGAH.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.85|      24|      67|     445|     470|       9
---------------------------------------------------------------------------
  445-  468 (38.94/16.05)	SRLSALLGSLIRSNPESFINPG............AW
  513-  536 (33.80/12.56)	SQLVKLLDAALKESSDNHLAAA............CW
  539-  574 (32.12/16.73)	SENKSLIMKTVVEWATSFHRPGlakvyaatrlirQW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27549 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MGAHPRPPQRSVSSSSLPVQRPPPQRSLSHQQQFMAAASPVRKDAPFIDLTADAGDATPNRYHTTPRRGGSRLRLELSHNASSSSLPTSESPQSLTPSRIPNSDPFQAMVGSPAGSASSTLMPMPTRRPVTSQPRFAPRITATAPAPAKKDARPKPY
1
157










Molecular Recognition Features






MoRF SequenceStartStop




1) APRITA
2) ARPKPYTVEI
3) FIDLTA
4) RLYYLF
137
152
47
1405
142
161
52
1410