<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27541

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASITFRIYEPPPDQSHGFQSSALEIQSSLRDQGKLVSYDADRVGIWMFQIVSKDGTSKAVNSAPGSSLEASGYTLGMVEEGNLEPVALQKSRIPGNTTQNAPNNTASTASPAEANSRNPLISPTQVAGGALPEGVSQSSAQVTDMRTTQPVPKIIYEQFIVAVISSIAFAFCSRSMAIPLNYRTMLIPPLLADANERERGSLQADPVVGTFKTYLTTTGSLVVSLTFSYCKNLATVEDVLTGDSSSPSSSVLAAPYGVFATKQNFANGDGSDRSLAQTPNTQALSVRSVPDTNDSQWKHSCLKALEYCGLNPSQFKASPWVNLLISKPTSQDADGESKRSRATVPWPGSLCFRKKPMEMSTTHRVGDTMLSGHEECHDPLGDARGWFAGASEREERISKRKAERMYAVTREVNGANPLAQNLNGQSPLTMRRPSTAAAGVMYPTPPDAIQQHIGITPSIDGAISTTPMADAENDAWGGQHEQKRERSDSNAMGDSDDVMNDLGEDVFGDHDVTEDDFNFFDGPDGNDLDMDMPDLQPAPTAPAPQVMPPPVLSHPEPHKAIQPQPEVKPKPKTNDSVFAKPELKHARSSLNDELNHRIKVERPDTAKRGSSPFDPATVFKRVRASLSSPTKDDFAVQPPRRKSSVFEKVEFDPKIPLINKKYEHGGAFDFSKDQSNGDSRPSAHNLSRDEYLEGQGKLKQTSKSLLGNSLIRSLTGIDASTTHASPQRLNGHDWISEESELESDGDDISSLSGGPVSPVKSSIKRTVVDDDALSQATTSRETELLDDVTDEQLAIELPKLSKTESPEMLLHRFFLDPEPLNVDVGLSNHDFVEIAQIITEQAATGRLEIGIEHKAESSVSLATMRSHELSIARNSLQLLHDAIPSNLGTPTAVRLKGLLEIQDLPLVGQPSRLQPRPIPGRDPNAEQLRANNLYQIPVPHLEVRRSETKLSVLPSSMSFWEGLGLSPSWGTKDISALCIFPGWKGMSDHVESFLSRLKSVYESLKLGTLNNLPLSGDWDDGVLPYEVDRISTSPDATVTGHGSALVESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTAFYRCFDEYSDLLAARRESPQNELVLQLVSLDMISSTTSLVVPTPAEMIKLCIETYDRCTLFLDTEFGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCLHVGYAESLDGRWITAAWTDNRGQRQATTSYSITRSRTPDRSVSHHKAAIIAEIWATTLTMISIWKVHWRVIITKSGAMDQKEVEWWQAASTLDDKHSFTMILMSVDTNPSLQLVPPIVKIPHAATSAFYSTPVSTPQANIVSPEQTTTPATPMRDASTLAATPTAEGAAEAEADSFLIDATDQTWGAIVGHRLCNSTTLLEVRPALASGYLIKRTGIKLEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVVDREMDVRPWHIAAAEKGVRALHLLL
Length1495
PositionKinase
OrganismFusarium oxysporum (strain Fo5176) (Fusarium vascular wilt)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.06
Grand average of hydropathy-0.385
Instability index47.65
Isoelectric point5.23
Molecular weight163309.71
Publications
PubMed=21942452

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27541
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     205.35|      64|      87|     344|     412|       1
---------------------------------------------------------------------------
  344-  400 (77.03/45.80)	..................................................PTSQDADGESKRS..RATVPWPGSL....cfRKKPMEMSTTHrVGDTMLSGHEECHDPLGDAR
  401-  488 (91.49/49.97)	GWfaGASEREER..................iskrkaermyavtrevnganPLAQNLNGQSPLTmrRPSTAAAGVM......YPTPPDAIQQH.IGITPSIDGAISTTPMADAE
  491-  578 (36.84/13.54)	AW..GGQHEQKRersdsnamgdsddvmndlgedvfgdhdvteddfnffdgPDGNDLDMDMPDLqpAPTAPAPQVMpppvlsHPEPHKAIQ.......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.46|      89|      95|     742|     836|       5
---------------------------------------------------------------------------
  745-  836 (137.72/108.86)	LNGHDWIsEESELESDGDDISSLSGGPVSPVKSSIKRTVVDDDALSQATTSreTELLDDVTDEQL....AIELPKLSKTESPEMLLHRFFLDPEPL
  842-  934 (138.75/90.44)	LSNHDFV.EIAQIITEQAATGRLEIGIEHKAESSVSLATMRSHELSIARNS..LQLLHDAIPSNLgtptAVRLKGLLEIQDLPLVGQPSRLQPRPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.56|      37|     535|     118|     154|       6
---------------------------------------------------------------------------
  118-  154 (63.70/35.35)	PNNTAST..ASP.....AEANSRNPLISPTQVAGGALPEGVSQS
  655-  691 (62.11/34.29)	PRRKSSV..FEK.....VEFDPKIPLINKKYEHGGAFDFSKDQS
 1358- 1393 (32.75/14.59)	PMRDASTlaATPtaegaAEAEADSFLIDATDQTWGA........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.99|      27|     406|     307|     335|       7
---------------------------------------------------------------------------
  307-  335 (46.58/37.59)	DTNDSQWKHSCLKALeyCGLNPSQFKASP
  716-  742 (45.41/29.23)	QTSKSLLGNSLIRSL..TGIDASTTHASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.16|      30|     822|     187|     249|       9
---------------------------------------------------------------------------
  191-  228 (41.28/75.07)	SMAIPLNYRTMLIPPllaDANerERGSLQADP..VvgtFK
  605-  636 (50.88/15.25)	SLNDELNHRIKVERP...DTA..KRGSSPFDPatV...FK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27541 with Med13 domain of Kingdom Fungi
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