Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MNNNYLRIQQLRESSNALDTQIRDTLSNLATTRKDIVTTQTTTFPSGPSYPIAYEELLNYARRISKTTMPPAGTIKAVPPTPDVPEVQTPGGQTPAAQTPGPESQAASVMTPSAPPSSQVQSPAVMNGTPVVSQEPATQQSSMSANTVLPSEWTQFLNPLTDQIFLPWPNDLQLGAGSLAANQLLQEQGIDPKGYDPAEEEERKRREEEERKQKEEEDRIAQEEREKKQREERERQRIERERQREKEQEAWRRASLVGGPAAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD |
Length | 294 |
Position | Middle |
Organism | Fusarium oxysporum (strain Fo5176) (Fusarium vascular wilt) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex. |
Aromaticity | 0.04 |
Grand average of hydropathy | -1.109 |
Instability index | 71.31 |
Isoelectric point | 4.65 |
Molecular weight | 32875.65 |
Publications | PubMed=21942452 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP27538 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 49.52| 14| 15| 206| 219| 1 --------------------------------------------------------------------------- 206- 219 (24.59/10.90) REEEERKQKEEEDR 222- 235 (24.93/11.13) QEEREKKQREERER --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 53.09| 16| 16| 97| 112| 2 --------------------------------------------------------------------------- 97- 112 (28.81/12.34) AQTPGPESQAASVM..TP 113- 130 (24.28/ 9.35) SAPPSSQVQSPAVMngTP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EQEAWRRASLVGGPA 2) QQKAQFQFTNLDDLDD 3) YLRIQQLR 4) YPIAYEELLNYARRISK | 247 274 5 50 | 261 289 12 66 |
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