<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27532

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMVPMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWSGLSQESHEQCVQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDSLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKAILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNGDSTLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHTKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSHRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTDENEIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYKVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQSDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMCLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKHAMNAREDNPWVPEDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVNVISSSSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEALLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAVPPQALNSGSPAPQSNQVPASLPVTQ
Length1370
PositionTail
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.10
Grand average of hydropathy-0.002
Instability index47.38
Isoelectric point6.92
Molecular weight156413.14
Publications
PubMed=19468303
PubMed=21183079

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27532
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.35|      55|     262|     974|    1029|       1
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  974- 1029 (97.23/72.25)	IHRFL..ELLPVSKSLETLL..DHLGG..LYKF.HDRPVTYLYNTLHYYEMCLrNRDHLKRKL
 1230- 1291 (81.12/54.83)	IPKFLteALLPVVKTEFQLLyvYHLVGpfLQRFqQERTRCMIEIGVAFYDMLL.NVDQCSTHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.79|      17|     127|     908|     925|       2
---------------------------------------------------------------------------
  908-  924 (35.55/18.71)	KENSPEHWLQSDWHTKH
 1038- 1054 (33.23/16.68)	KDNRPQGWCLSDTYLKH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     306.34|      96|     262|     525|     627|       3
---------------------------------------------------------------------------
  525-  627 (152.98/125.96)	PLPMNLLDSLTVHAKMslIHSIATRVIKLAHTKSSValapALVETYSRLLVYMEIESLG...IKGFISQLLPTVFKSHAWGiLHTL...LEMFSHRMHHIQPHY.RVQLL
  790-  892 (153.36/106.26)	PLFLCLLWKMLLETDH..ISQIGYKVLERIGARALV....AHVRTFADFLVYEFSTSAGgqqLNKCIEILNDMVWKYNIVT.LDRLilcLAMRSHEGNEAQVCYfIIQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.05|      34|     128|     932|     966|       4
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  191-  227 (38.46/17.27)	.RKLYPEGklphwlL.GNLVSDFVDTFRPTARI..NSIC.GR.
  932-  966 (62.02/36.50)	PEKLYFEG......L.AEQVDPPVPIQSPYLPIyFGNVC.LRF
 1066- 1097 (52.57/26.07)	PEDSYYCK......LiGRLVDTMAG.KSPG.P..FPN.CdWRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      32|     342|     351|       6
---------------------------------------------------------------------------
  342-  351 (18.69/10.32)	IFFVLFQFAS
  375-  384 (19.45/11.06)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.04|      36|     373|     724|     781|       7
---------------------------------------------------------------------------
   32-   67 (66.34/32.84)	TPEDEKTKLISCL.AAFRQFW..SGLSQESH........EQCVQW.........IV
  726-  781 (44.71/63.53)	TPHNWASHTLSCFpAPLQAFFkqNNVPQESRfnlkknveEEYRKWksmtdeneiIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.44|      55|     867|     271|     325|       8
---------------------------------------------------------------------------
  271-  325 (98.72/68.99)	ALLRYVLE.QP.YSRDMVC...NMLGL..NKQHKQRCPVLEDQLVDLVVYAMERSETE......EKFD
 1128- 1195 (69.72/46.37)	ALLNVVLKsQPlVPRENITawmNAIGLiiTALPEPYWIVLHDRIVNVISSSSLTSETEwvgypfRLFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.07|      10|      27|     138|     147|      12
---------------------------------------------------------------------------
  138-  147 (15.60/10.40)	RDLLKAILEK
  167-  176 (16.48/11.44)	REVIAYILER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27532 with Med23 domain of Kingdom Metazoa
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