<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27530

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length1809
PositionKinase
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.07
Grand average of hydropathy-0.415
Instability index53.36
Isoelectric point7.62
Molecular weight203778.24
Publications
PubMed=16641997
PubMed=18669648

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27530
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     159.21|      29|     150|     753|     781|       1
---------------------------------------------------------------------------
  753-  781 (50.37/25.62)	CL..ILNPDQTAQVFEG...L...CGVVKHV..V.NPSEC
  902-  931 (38.39/17.92)	CT..VLSSEWLG.VLKA...L...CCSSNHVwgF.NDVLC
  943-  969 (23.42/ 8.30)	SLatFIAILIARQCF.S...L...EDVVQHV..A.LP...
  970- 1001 (25.53/ 9.66)	SL..LAAACGDADAEPGarmT...CRLLLHL..FrAPQA.
 1002- 1022 (21.50/ 7.06)	CF..L..PQATGKPFPG...IrssCD..RH..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     157.49|      49|     150|    1605|    1656|       2
---------------------------------------------------------------------------
   27-   61 (27.65/ 8.17)	...................QDPKQKEDELTavnvkqgfnNQPAFTGDE....HGSARN
 1605- 1634 (35.10/12.38)	...................QEPERKSAELS.........DQGKTTTDEEKKTKGRKRK
 1638- 1656 (19.10/ 6.26)	SSRVDEYPQSNIYRVPPNY.......................................
 1660- 1704 (75.63/33.01)	SSQMMHHPQSTLWGYNLVGQ.PQQPGFFLQ.........NQSLTPGGSRLDPAGS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.11|      10|      14|    1071|    1081|       4
---------------------------------------------------------------------------
 1071- 1081 (16.69/15.14)	CdGNADDIWTA
 1088- 1097 (18.42/10.51)	C.GKSISIETA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.87|      26|      27|    1745|    1770|       6
---------------------------------------------------------------------------
 1738- 1753 (19.80/ 6.23)	..........QQLIQMKLLQQQQQQR
 1754- 1779 (48.80/26.04)	LLRQAQTRPFQQFPRQGLQQTQQQQQ
 1783- 1799 (21.28/ 7.24)	LVRQLQKQLSSNQPQQG.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.51|      24|      29|    1120|    1148|       7
---------------------------------------------------------------------------
 1106- 1132 (38.59/16.31)	VLRTICQQEWVgehCLKEPERLCTDKE
 1138- 1164 (37.92/26.92)	VLSNMQAQKLLqliCYPHGIKECTEGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.44|      17|      76|    1218|    1234|       9
---------------------------------------------------------------------------
 1213- 1229 (27.96/17.50)	LDNIAKATIEVFQQ....SAD
 1230- 1250 (24.48/14.37)	LNNSSNSGMSLFNPnsigSAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.29|      12|      29|     592|     603|      11
---------------------------------------------------------------------------
  592-  603 (22.36/16.71)	GVGKERDEARHQ
  624-  635 (21.93/16.22)	GVGDEGQKARKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.00|      17|     152|    1294|    1334|      14
---------------------------------------------------------------------------
 1294- 1310 (27.43/11.46)	G.EELEKGQHLGSSSKKE
 1513- 1530 (21.57/20.61)	GfDSIDKKQGLQVSTKQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.81|      17|      29|    1338|    1354|      18
---------------------------------------------------------------------------
 1338- 1354 (28.61/18.34)	QDE..QREGLLTSLQNQVN
 1366- 1384 (25.21/15.19)	QDDikARQMMHEALQLRLN
---------------------------------------------------------------------------











Associated diseases
Disease
breast cancer	PMID:29157917 PMID:30230586 PMID:27438523 PMID:26452386 PMID:26601288 PMID:22913342
prostate cancer	PMID:29157917 PMID:23836153 PMID:23661306 PMID:22610119 PMID:26924278 PMID:26383637
colon cancer	PMID:23178117 PMID:29507187
renal cell carcinoma	PMID:27050271
uterine tumors	PMID:31520353 PMID:26383637
Uterine leiomyoma (ULM)	PMID:33025089 PMID:23443020 PMID:30895261
endometrial polyps colorectal cancers	PMID:24980722
phyllodes tumors	PMID:25865354 PMID:30511242
extrauterine cancer	PMID:25595892
uterine smooth muscle tumors	PMID:28592321
colorectal cancers	PMID:23132392 PMID:28183795
castration-resistant prostate cancer	PMID:24938407
Breast fibroepithelial tumors	PMID:26437033
fibroadenomas	PMID:28513873
epithelial ovarian cancer	PMID:29735544
Thyroid Cancer	PMID:28634282
lung cancer	PMID:28055980
renal cancer	PMID:24504440 PMID:30895261
syndromic disorders Congenital heart disease	PMID:30905399
cardiovascular diseases	PMID:24751643
Alzheimer disease	PMID:21293490
Fragile X syndrome	PMID:31098807
uterine leiomyomas	PMID:25615570 PMID:32094355 PMID:25106763 PMID:30619444
Blepharophimosis	PMID:24715367
short humeri	PMID:24715367
hirschsprung disease	PMID:24715367
Goldberg-Shprintzen syndrome	PMID:24715367
Opitz-Kaveggia syndrome	PMID:24715367
breast fibroadenomas	PMID:25106763
pelvic inflammatory disease	PMID:28432313



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27530 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAI
2) RSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMH
3) TQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
1683
1581
1774
1734
1665
1809










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGLLSYEQRPLKRPRLGPPDVY
2) RSYYLQPLPLP
1
1581
25
1591