<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27529

Description Mediator of RNA polymerase II transcription subunit 13-like (Fragment)
SequenceMLESRKAIAPSRRKAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFSAGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRP
Length1081
PositionMiddle
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.06
Grand average of hydropathy-0.528
Instability index65.41
Isoelectric point6.12
Molecular weight118650.07
Publications
PubMed=16541075
PubMed=18691976
PubMed=19369195
PubMed=19690332
PubMed=23186163

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27529
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.88|      34|      38|      14|      51|       1
---------------------------------------------------------------------------
   14-   51 (53.77/47.37)	KAELTGIkWRRynfGGHGDCGPIISAPAQDDPILLSFI
   55-   88 (68.11/44.51)	QANLLCV.WRR...DVKPDCKELWIFWWGDEPNLVGVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     197.73|      36|      36|    1010|    1045|       2
---------------------------------------------------------------------------
  192-  223 (27.95/ 7.22)	.....S....SPAPfqvlVSPYGlNGTLTGQAY.KMSDPATR...................
  388-  429 (39.98/13.27)	TP.TLE.....EEP....ASN.........PATWDFVDPTQRvscscsrhkllkrcavGPN
  430-  456 (26.72/ 6.60)	RPPTVSqpgfSAGP....SSSSS....LPPPASSK..........................
  546-  567 (33.67/10.09)	.PPTL.....SPQP....R..........GQET.ESLDP.PS................VP.
 1010- 1045 (69.41/28.09)	TPVTLN....SAAP....ASNSG.AGVLPSPATPRFSVPTPR................TPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     175.38|      33|      36|     847|     879|       3
---------------------------------------------------------------------------
  847-  879 (60.56/35.99)	TVADLQRMFPTP.PSL..EQHPAFSPVMNY.KDGISS
  881-  913 (37.13/18.68)	TVTALG.MMESPmVSMvsTQLTEFK..MEV.EDGLGS
  918-  937 (29.78/13.25)	EIKDFSY........V..HKVPSFQPF.......VGS
  958-  990 (47.91/26.64)	DACLFRPSWAIP.PKI..EQLP.MPPAATFiRDGYNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.80|      24|      36|     615|     642|       4
---------------------------------------------------------------------------
  615-  642 (39.12/32.63)	NPESSEkwwhSYRLPPSDDAEF.....RPPELQ
  653-  681 (35.68/17.85)	NSESTA....LQRLLAQPNKRFkiwqdKQPQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.82|      34|      36|     764|     799|       5
---------------------------------------------------------------------------
  764-  799 (51.18/31.74)	IFSSATKTDVRQDNAAGRagSSSLTQV.TDLAPSLHD
  803-  837 (53.64/27.83)	IFDNSDDDELGAVSPALR..SSKMPAVgTEDRPLGKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.75|      29|      41|     290|     318|       6
---------------------------------------------------------------------------
  290-  318 (56.78/28.30)	SAGGHIAVGQQGLGSVK.DPSNCGMPLTPP
  334-  360 (45.63/21.37)	SAASHLVSQDGGMITMH.SPKRSGK..IPP
 1052- 1076 (33.34/13.72)	..GGGTASGQ...GSVKyDSTDQGSPASTP
---------------------------------------------------------------------------











Associated diseases
Disease
breast cancer	PMID:26452386



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27529 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVP
2) CAVGPNRPPTVSQPGFSAGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLEL
3) ECILNRTQSKRSQMSTPTLEEEPASNPATWDFV
4) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTD
5) KDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLH
6) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRP
794
424
373
726
306
994
843
579
405
792
363
1081










Molecular Recognition Features






MoRF SequenceStartStop




NANANA