<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27524

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDHARNGANGVVELDTRIQNPPSPLANGFHVNGVHEHTPEELERELPVVYDGQVALGEVLSRVVQAIYAELSELAETLPNMSDTARKRTLADWVVKTKKQVVKLYAITKWARDAQTVQKCMNITAFLMNQNQQFEDVMRGLTYAKESLDPARLRNHDLLTSLDVLTTGSYRRLPSVIKKLIVPPTPLMDAEVAKTLTDMEDAIRLRLRMHEIIPVEMSQHRIVICAIADGRAHFTVPKLFEVSLCLRGAERNDGWFFVGVKFLITVGGDLTGMQEFPQMPTGMLKRHIADEADARLAYYIPLPQEEEPVPGVEVPPRPQLPEGTADAPLVRVFNFLQVMSLSYQLEILWYQAQRMRSLGWADYLKVEMSNGRKTLTVSYWVRQLPPSIPGRPQPPNRSKLPLTGGTLTISIVESRAPPQVGGGPIRSPIARVLAELQQKSKLGNLRPSDEAEGLKFQVVWEPIKGAFGVVIAAVDAVMANDLLVVNPYNLDFESLLRKVIKQHTKAILNVFQTQLQRGPTRTVFSPPGEVVLTEEGGSYALRIHLCADEVVVISIDTRTGRLNLRDTGDLAAAGRGPRFTAISERLNQDPSLLLDALVRLRLNTITDLAEQKANYLGLHSYRQRNFSREELHKLGPSARGMLYIQLSNFPNHYLVLVITDEEFRYALISVRVLTDTMYANLIMEDIAWLDVQRIRGDNNAIFDITGGLSAPMDGSELQMGHKRKRNAEDDIVKEEKGKERREGSFNLETQVLRELYAYCCARVAYTKVEQQFKIRGIPYSHVNPTSGYPLPSELSQIQSSLARSVPALCVQSSDILSGAPAAEAAMPNIRVIPLNWWSNKKVQVVTCVKLKYVQQPVGRRANGGSSIIRPSKRIIYDTTEAVVSFLSEEVDMCVDEFLEEWARVSKMVVIAREVAQMAEDGKWPDVRLLSFDLQTVEFAYAHDYTVSIRCMDQLSPTGGSFDLRFSRCPPSDPQARATSPPPFQDRKNPHEDVEPFLQQILRHGPLTSSLHRLVELLRDTLPIVVEIERMRLEPGSSSSMSPNRGRGKGKGKAVVGWENEPWVETFVKGLGWYRVLYGDLRHALDFRLMNNQRVAIIDGSHSLFGSDVSGSASVSSTSSPDLLGLQAIPDLPSLIQAAVHSVRSASGGLSLGKIAPIDVGIVCNTGAVGAVARALHERILKKLQGEYS
Length1188
PositionTail
OrganismSerpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Boletales> Coniophorineae> Serpulaceae> Serpula.
Aromaticity0.07
Grand average of hydropathy-0.202
Instability index44.10
Isoelectric point7.34
Molecular weight132277.34
Publications
PubMed=21764756

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27524
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.57|      55|      77|     671|     727|       1
---------------------------------------------------------------------------
  671-  727 (87.92/67.83)	RVLTDtMYANLIMEdIAWLDVQ...RIRGDNNAIFDITGGLSAPMDGSELQMGHKRKRNA
  750-  807 (91.65/61.22)	QVLRE.LYAYCCAR.VAYTKVEqqfKIRGIPYSHVNPTSGYPLPSELSQIQSSLARSVPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.40|      38|     286|     853|     890|       2
---------------------------------------------------------------------------
  853-  890 (65.84/46.17)	VQQPVG..RRANGGSSI..IRP.SKRIIYDT..TEAVVSFLSEEV
 1135- 1179 (46.55/30.33)	IQAAVHsvRSASGGLSLgkIAPiDVGIVCNTgaVGAVARALHERI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.05|      20|      79|     298|     324|       3
---------------------------------------------------------------------------
  302-  324 (35.60/19.77)	LPqeeEPVPGVEVPP.RPQLP..EGT
  384-  406 (30.45/ 7.99)	LP...PSIPGRPQPPnRSKLPltGGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.65|      34|     403|     163|     210|       6
---------------------------------------------------------------------------
  163-  207 (51.05/43.65)	DVLTTGSYRRLPSVIKKLIVPPTPLMDAEVaktltdmedaiRLRL
  569-  602 (57.60/26.82)	DLAAAGRGPRFTAISERLNQDPSLLLDALV...........RLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     227.86|      52|     788|     109|     161|       7
---------------------------------------------------------------------------
  109-  161 (84.43/58.33)	KWAR....DAQTVQKCMNITAFLMNQNQQFEDVmRGLTYAKESLDPARLRNHDLLTS
  900-  947 (77.32/48.37)	EWAR....VSKMVVIAREVAQ..MAEDGKWPDV.RLLSFDLQTVEFAY..AHDYTVS
  964- 1009 (66.11/40.26)	RFSRcppsDPQA..RATSPPPFQDRKNPH.EDV........EPFLQQILRHGPLTSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.23|      16|      35|     419|     434|       9
---------------------------------------------------------------------------
  419-  434 (28.24/14.99)	QVGGGPIRSPIARVLA
  457-  472 (29.00/15.59)	QVVWEPIKGAFGVVIA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27524 with Med14 domain of Kingdom Fungi
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