<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27519

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMASKSAHASSSHSSSPSTTMSHLPPHVSLSEQVLSSVVSLPDNPVIAYTTFTTQSTTIRPYEALELARRLLVNRNKGLPLLDSLLPCVNVSQDLSALQVFAITSRDHVSAKLAAIKDISFDGLTVSGESSFTPHDLYPCSLACSDDQSPCPSCLKRDPSSLSQSTLSSPACLLPRKPLRSAYYHFLDAVRKRLIDDISEASRKTPHGRCARGFQDGFLLSPPRSYFDWGVDWQHHVNTRPFIHCHLEIHLATSRLEIHPIIRPTHFSPLSVHLPLAPGTPIALMPYSTPAFFLATYTGPTSALSAQFEQSLAGLGAGDWKTMTSPYSHSVSNGKHRSADPSARKYPMYIIAWLAVENKQGEDKGMNIIWPTELCLSYLPSSKSAHARQTLAYIPDLPPPLQPSPPPPPPPAISISSPVSAGGDGGPTSPIELNSHRISRPVISRICTSPTGEYLRAFRSLTVSKSKGLDEIATEVGGYVEVVAKEREKERERIRRERENAHFSASPRAVVTPPTALPSSITPGVSMLATTSVDIVATPQHSQPPASAQTSPTTVASNQDSQPVSIPHQQFYPSPPQTNLPSGAHSTGQDSLMSSVEPTSALPTTAASEPEPVVNDPIPQPENISSSSSYDPFNMEPSWAQSNDDFMSIGMDYNMSFGISMDPIGGGGAGGGGAADRLDMDFEDGFTFTDDDFSFFDRPSASTRLPAVADSTLENTTINTGLTPAAGPAPLGLSPPTYGDGIHFSGSGSGPGPPPTPGQLHFPPWNPGALAEGYSPRFIDHPHAHDVIPPAPDLLPPSPGKTPSSHSAPVTPNVHVYGSDAYRPTSSNSNIFDPIPFANSHRIADGKYTFGKFALPSPPDEEDRTEPIPLSSSPLHLQGWKLRYNAVTDPRIGVVRKLIGVKRKSFDQGSRDHKSFSSWKREHEDWVSSNVVDDVEENKSDAESEDDDVEIDDLPVASRTSTPPPAYLPMGPTLLHTYFHHSLLLPLSNPLRPPGAAVAPTNIPTVAPTSVPTPVSPAAALGTASEKSKFLEAAGYMVASEMVENSVWADAWRSNFLSASVRPTSEIWKSDVSTLVQLVKDVPDMEGPLDLQTLFQLKTEHTSQLEETVLQKLEPPMFSICKSDSVIQVLPSAIRFWEKLGLGPLGGKKDIIAFVLFDEEGPEKQNQAEGWLNSISVMYTAKQLGTHVPGSCTGCPKDGIMPLRFDSFRKSLASFVASLPTSQSSLVFYIVTPDTAMSLASPLLRQVFSAVKRAQKTYSEAQILFQFVPERLIRSVGSSTNQDMDIEALCYSVYRRVPQPVDRYMSRRFSENGERIRNYFQEQPFTLARPLCNRVSFTLQSPARTLDVVDRHTLLHIGYQTSACGKWLIAACVDQRGEAHDLGVWLIQGDWEAFVVEQVWKFAVQFARKANIEWRLIFTKLGSMSENELNAWSSHLATVVPACSELPPFYVSLFSVDQGMPWTFISPKSSVNPSTPKRSPGKDCTKHIYLDVSATTYALFSPSPMPLMSPLSSATRDGADVSTIPDNEEMPPRDTLGVMPLSTTMLIRAPAASGHTAITMIHIHLLHSMKSPNSSLSTSDHETHKDVTRNFHELAVLSESTHRLRANPILPFHLAALETMHGALTQGDVE
Length1629
PositionKinase
OrganismSerpula lacrymans var. lacrymans (strain S7.3) (Dry rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Boletales> Coniophorineae> Serpulaceae> Serpula.
Aromaticity0.08
Grand average of hydropathy-0.294
Instability index60.26
Isoelectric point5.90
Molecular weight177213.74
Publications
PubMed=21764756

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27519
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     942.06|     223|     243|     392|     634|       1
---------------------------------------------------------------------------
  272-  384 (72.36/16.60)	.................................................................................................................................HLPLAPGT...P.IALM.PYS.TPAF.FLATYTGPtSALSAQFEQS..LAGLG..agdWK.....TMTSPY.SHSVSNGK.HR.......SADPSARKYPmyiiawlavenkqGEDKGMNIIWPTelclSYL.......PSSkSA....................
  395-  624 (371.50/149.51)	D.........LP.PPLQPSPPP......PPPPAISIS.SPVSAGGDGGPtspIELNSHRISRP...VISRICTSPTGEY...LRAFRSLTVSKSKGLDEIATEVGGYVEVVAKEREKERERIRRERENAHFSASPRAVVTP.PTAL.PSSITPGVSMLATTSVD.IVATPQHSQP..PASAQ.....TSPT...TVASNQDSQPVSIPH.QQFYPSPPQTNLPSGAHST.............GQDSLMSSVEPT....SAL.......PTT.AASEpepvVNDPIP..QPENIS
  636-  843 (268.62/88.72)	.............PSWAQSNDDfmsigmDYNMSFGISmDPIGGGGAGGG...........................GAA...DR....LDMDFEDGFTFTDDDFSFFDRPSASTRLPAVADSTLENTTINTGLTPAA..GPaPLGLsPPTYGDGIHFSGSGS......GP..GPP..PTPGQlhfppWNPG...ALAEGYSPRFIDHPHaHDVIPPAPDLLPPSPGKTP.............SSHS..APVTPN....VHVygsdayrPTS.SNSN....IFDPIPfaNSHRIA
  844- 1025 (229.59/73.70)	DgkytfgkfaLPsPPDEEDRTE......PIP..LS.S.SPLHL..QG.....WKLRYNAVTDPrigVVRKLIGVKRKSFdqgSRDHKSFSSWKREHEDWVSSNVVDDVEENKSDAESEDDDV....EIDDLPVASRTSTPP.PAYL.PM....GPTLLHTYFHH.SLLLPL.SNPlrPPGAA.....VAPTnipTVA......PTSVP........................................TPVSPA....AAL.......GT...ASE..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.27|      23|     240|    1263|    1285|       2
---------------------------------------------------------------------------
 1263- 1285 (40.06/22.92)	LFQFVPERLIRSVGSSTNQDMDI
 1498- 1520 (41.21/23.83)	LFSPSPMPLMSPLSSATRDGADV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.48|      25|     132|      11|      51|       3
---------------------------------------------------------------------------
   11-   36 (41.17/16.04)	SHSSSPSTTMSHLPPHvSLSEQVLSS
  144-  168 (45.30/14.73)	SDDQSPCPSCLKRDPS.SLSQSTLSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.01|      16|     337|    1187|    1202|       5
---------------------------------------------------------------------------
 1187- 1202 (33.98/16.45)	VPGSCTGCPKD..GIMPL
 1523- 1540 (28.03/12.31)	IPDNEEMPPRDtlGVMPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27519 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EVGGYVEVVAKEREKERERIRRERENAHFSASPRAVVTPPTALPSSITPGV
2) HDVIPPAPDLLPPSPGKTPSSHSAPVTPNVHVYGSDAYR
3) MLATTSVDIVATPQHSQPPASAQTSPTTVASNQDSQPVSIPHQQFYPSPPQTNLPSGAHSTGQDSLMSSVEPTSALPTTAASEPEPVVNDPIPQPENISSSSSYDPFNMEPSWAQS
4) PLSSATRDGADVSTIPDNEEMPPRDTLGVM
5) QTLAYIPDLPPPLQPSPPPPPPPAISISSPVSAGGDGGPTSPIELNS
6) RLPAVADSTLENTTINTGLTPAAGPAPLGLSPPTYGDGIHFSGSGSGPGPPPTPGQLHFPPWNP
7) VSSNVVDDVEENKSDAESEDDDVEIDDLPVASRTSTPPPAY
474
784
526
1509
388
703
926
524
822
641
1538
434
766
966










Molecular Recognition Features






MoRF SequenceStartStop




NANANA