Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MAPVTANHQEAQESVKNVIQDILNLMVQVSQYDTNPSSSNNNTPTNRAGGGGGHPSSREVITQSLQTLDASLLSVYRTASLLPSSPSSPSHSSLPGGGTTELERAEAAQFASTFANTHNPYAPHLHQPGPQNPGIPIPLITYVENGRNPDVYTREFIELMHAFRDFRDVLAGEMEAALPELREDVRRVVEATGGPGPAEGSEEKAREGVVASMAVGGDGQGQAGGGQGQGGQQ |
Length | 233 |
Position | Middle |
Organism | Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Sordaria. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.551 |
Instability index | 53.28 |
Isoelectric point | 4.92 |
Molecular weight | 24476.52 |
Publications | PubMed=20386741 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP27507 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 108.38| 36| 43| 16| 58| 1 --------------------------------------------------------------------------- 18- 58 (61.08/36.53) VIQDILNLMVQ..VSQYDT......NPSS.SNNNTPtnragGGGGHPSSR 60- 104 (47.30/16.87) VITQSLQTLDAslLSVYRTasllpsSPSSpSHSSLP.....GGGTTELER --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IPIPLITYV 2) SEEKAREGVVASMAVGGDGQGQAGGGQGQGGQQ | 135 201 | 143 233 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab