<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27506

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGHMNGVRTHHDRNSWTNGVNGGVVKREGSPDKGKALANMSGSSAMTNGGSASFMDVDSQPPGGSKFNDLPEEIQHITADIMPLSLLLTRLSQWTHSKLQDEIAYLASKPLPQPVLNGNTSHQSADNHDTSQESLEKKVHLLNFLQDMHSKWVKTLVITEWSKKAAQVGALIDIRVHLLTKQAHYQELFWELIRMKQDLHWAKVPGPDLKTALEVLTTGQAPWMPELGYIEPPPITWEEKEAFIDNINTMLSVRLTFDEHEKIPAPFRDYNIANGRVTFKAKGEFEVDLTIGDEDFEQQFWFIDFRFLFTPAPAELSHGVRTFLENKINIILGNEGLAGCYKYLHEFVLTQKIVEFRRQANELAVGRWVDTLKVEKLNRAMSIQYWLKPPNSLEGPSSQTAKSWILLGVWSENSVQEDLDSKPSSYINLRWFRDNKEVKDFEIPLDVETISAEKLLTAVIASHVEYILTSISSKLLSKPRFAQKHARLDVKISKEEPQNSSLAVQLFDNDEAVIKIEPLTGLFTLFPRSPVFLKGQMKLNTSSNAAEEGAHLMEQLRFDYTVKDLNSRVRSIGWFVCRPPITQEETKAIVYSDASGSREPFKAVWLRKANWMTRQWFVMMSMSLGGDQWWLIDLSPPKPNFPAGRLRLFTKMPMTSNQLTLSDTFFRNLSVYAAGMISHITDLRKLHTLKKSHTALELPNHSLPPQVRLPTIYVRLSEMLEKRPGSSSRTLAWAKDFVPIIFKGVRTHTGDQEGPANATAAQVRRDTPAKIRAEARLTVIDRSKFKSLRGNVDHDVVYNHRTGQFSLKLRADMGTPVVDLLADRVQALERLMEFVEAIRLAGSNAIPQSVALREVVFTYSNDPAETVSNPPQGPRAWSVHLDLPKGAKVILTLEKGNPHMRALDMLQEMAQSTKTELLPSYLPFSLPLYRVLDRIEDEWDNIAAKNAGSVAIVVKAAEWVTVRFKLPAPTTRRLLCLDIRTMGRKGRLLWHVKRTDEKGHERPLNGPQDEFDTLLQRSVWHAHGDGRKSFGTSAAADPKIGIETLLWSISESVKSLVGTAPPPPITAPHPGGGVQDVKQSPQQPPQQLVVTQATQAAQGIPPQRPKQQPPPSSQSQQQHRSVNQPQAQPQPQALPQTQVQLPQAQVAQLQAQRQAQARANNNRFVNRAHPGQPQQRQPGPPTQAQQQQQRYQIQQQAQAMQRMQQQQQQQAAQQHAQQQGGQVQQGQRPVHGGQGGPQGVPQGQPGQGGAGGGGMGGKNAPVVVID
Length1268
PositionTail
OrganismSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Sordaria.
Aromaticity0.07
Grand average of hydropathy-0.510
Instability index47.07
Isoelectric point9.23
Molecular weight141946.80
Publications
PubMed=20386741

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364147
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP27506
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     172.40|      21|      22|    1187|    1207|       1
---------------------------------------------------------------------------
 1108- 1133 (27.14/ 9.59)	KQqpppssQSQQQ.......H.RSV.NQPQAQPQP
 1134- 1161 (22.41/ 6.64)	QA......LPQTQvqlpqaqV.AQLQAQRQAQARA
 1162- 1179 (24.13/ 7.71)	NN......NRFVN.......R....AHPGQPQQRQ
 1185- 1205 (37.73/16.20)	QA......QQQQQ.......R.YQIQQQAQAMQRM
 1206- 1223 (32.58/12.98)	QQ......QQQQQ.......A.AQ.QHAQQ..QGG
 1224- 1245 (28.42/10.39)	QV......QQGQR.......PvHGGQGGPQGVPQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.89|      32|      39|     576|     609|       2
---------------------------------------------------------------------------
  576-  609 (53.88/37.07)	WFVCRPPITQEETKAIVysDASGSREPFKAVWLR
  618-  649 (63.02/37.14)	WFVMMSMSLGGDQWWLI..DLSPPKPNFPAGRLR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     754.71|     253|     737|       8|     286|       3
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    8-  286 (383.07/322.02)	GVRTH.HDRNSWTNGVNGGVvkREGSPDKGKALANMsgsSAMTNGGSASFM.DVDSQPPGGSKFNDLPEEIQhitADI.MPLSLLLTRLSQwTHSKLQD..EIAYLA.SKPLPQPV.LNGNTSHQSADNHDT....SQESLEKKVHLlnflqDMhSKWVKTLVITEwsKKAAQVGALiDI........RVHLLTKQAHYQ.ELFWELIRMKQDlhWAKVPGPDLKTAleVLTTGQAPWMpELGYIEPPPITweeKEAFIDNINTM.LSVRLTF.....DE..HEK.IPAPFRDYNIANGRVTFKAKGE
  746- 1027 (371.63/239.57)	GVRTHtGDQEGPANATAAQV..RRDTPAKIRAEARL...TVIDRSKFKSLRgNVDHDVVYNHRTGQFSLKLR...ADMgTPVVDLLADRVQ.ALERLMEfvEAIRLAgSNAIPQSVaLREVVFTYSNDPAETvsnpPQGPRAWSVHL.....DL.PKGAKVILTLE..KGNPHMRAL.DMlqemaqstKTELLPSYLPFSlPLYRVLDRIEDE..WDNIAAKNAGSV..AIVVKAAEWV.TVRFKLPAPTT...RRLLCLDIRTMgRKGRLLWhvkrtDEkgHERpLNGPQDEFDTLLQRSVWHAHGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.68|      24|      39|     288|     312|       4
---------------------------------------------------------------------------
  288-  312 (37.95/30.24)	EVDLTIGDEDFEQQFWFIDfRFLFT
  329-  352 (40.74/26.90)	KINIILGNEGLAGCYKYLH.EFVLT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.99|      20|      22|    1067|    1087|       5
---------------------------------------------------------------------------
 1067- 1087 (34.16/18.77)	ITAPHPGGGVQDV.KQSP.qQPP
 1090- 1112 (26.83/10.14)	LVVTQATQAAQGIpPQRPkqQPP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27506 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LVGTAPPPPITAPHPGGGVQDVKQSPQQPPQQLVVTQATQAAQGIPPQRPKQQPPPSSQSQQQHRSVNQPQAQPQPQALPQTQVQLPQAQVAQLQAQRQAQARANNNRFVNRAHPGQPQQRQPGPPTQAQQQQQRYQIQQQAQAMQRMQQQQQQQAAQQHAQQQGGQVQQGQRPVHGGQGGPQGVPQGQPGQGGAGGGGMGGKNAPVVVID
2) MENGHMNGVRTHHDRNSWTNGVNGGVVKREGSPDKGKALANMSGSSAMTNGGSASFMDVDSQPPGGSKFNDLPE
1058
1
1268
74










Molecular Recognition Features






MoRF SequenceStartStop




NANANA