<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27506
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MENGHMNGVRTHHDRNSWTNGVNGGVVKREGSPDKGKALANMSGSSAMTNGGSASFMDVDSQPPGGSKFNDLPEEIQHITADIMPLSLLLTRLSQWTHSKLQDEIAYLASKPLPQPVLNGNTSHQSADNHDTSQESLEKKVHLLNFLQDMHSKWVKTLVITEWSKKAAQVGALIDIRVHLLTKQAHYQELFWELIRMKQDLHWAKVPGPDLKTALEVLTTGQAPWMPELGYIEPPPITWEEKEAFIDNINTMLSVRLTFDEHEKIPAPFRDYNIANGRVTFKAKGEFEVDLTIGDEDFEQQFWFIDFRFLFTPAPAELSHGVRTFLENKINIILGNEGLAGCYKYLHEFVLTQKIVEFRRQANELAVGRWVDTLKVEKLNRAMSIQYWLKPPNSLEGPSSQTAKSWILLGVWSENSVQEDLDSKPSSYINLRWFRDNKEVKDFEIPLDVETISAEKLLTAVIASHVEYILTSISSKLLSKPRFAQKHARLDVKISKEEPQNSSLAVQLFDNDEAVIKIEPLTGLFTLFPRSPVFLKGQMKLNTSSNAAEEGAHLMEQLRFDYTVKDLNSRVRSIGWFVCRPPITQEETKAIVYSDASGSREPFKAVWLRKANWMTRQWFVMMSMSLGGDQWWLIDLSPPKPNFPAGRLRLFTKMPMTSNQLTLSDTFFRNLSVYAAGMISHITDLRKLHTLKKSHTALELPNHSLPPQVRLPTIYVRLSEMLEKRPGSSSRTLAWAKDFVPIIFKGVRTHTGDQEGPANATAAQVRRDTPAKIRAEARLTVIDRSKFKSLRGNVDHDVVYNHRTGQFSLKLRADMGTPVVDLLADRVQALERLMEFVEAIRLAGSNAIPQSVALREVVFTYSNDPAETVSNPPQGPRAWSVHLDLPKGAKVILTLEKGNPHMRALDMLQEMAQSTKTELLPSYLPFSLPLYRVLDRIEDEWDNIAAKNAGSVAIVVKAAEWVTVRFKLPAPTTRRLLCLDIRTMGRKGRLLWHVKRTDEKGHERPLNGPQDEFDTLLQRSVWHAHGDGRKSFGTSAAADPKIGIETLLWSISESVKSLVGTAPPPPITAPHPGGGVQDVKQSPQQPPQQLVVTQATQAAQGIPPQRPKQQPPPSSQSQQQHRSVNQPQAQPQPQALPQTQVQLPQAQVAQLQAQRQAQARANNNRFVNRAHPGQPQQRQPGPPTQAQQQQQRYQIQQQAQAMQRMQQQQQQQAAQQHAQQQGGQVQQGQRPVHGGQGGPQGVPQGQPGQGGAGGGGMGGKNAPVVVID |
Length | 1268 |
Position | Tail |
Organism | Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Sordariomycetidae> Sordariales> Sordariaceae> Sordaria.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.510 |
Instability index | 47.07 |
Isoelectric point | 9.23 |
Molecular weight | 141946.80 |
Publications | PubMed=20386741
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP27506
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
6| 172.40| 21| 22| 1187| 1207| 1
---------------------------------------------------------------------------
1108- 1133 (27.14/ 9.59) KQqpppssQSQQQ.......H.RSV.NQPQAQPQP
1134- 1161 (22.41/ 6.64) QA......LPQTQvqlpqaqV.AQLQAQRQAQARA
1162- 1179 (24.13/ 7.71) NN......NRFVN.......R....AHPGQPQQRQ
1185- 1205 (37.73/16.20) QA......QQQQQ.......R.YQIQQQAQAMQRM
1206- 1223 (32.58/12.98) QQ......QQQQQ.......A.AQ.QHAQQ..QGG
1224- 1245 (28.42/10.39) QV......QQGQR.......PvHGGQGGPQGVPQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 116.89| 32| 39| 576| 609| 2
---------------------------------------------------------------------------
576- 609 (53.88/37.07) WFVCRPPITQEETKAIVysDASGSREPFKAVWLR
618- 649 (63.02/37.14) WFVMMSMSLGGDQWWLI..DLSPPKPNFPAGRLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 754.71| 253| 737| 8| 286| 3
---------------------------------------------------------------------------
8- 286 (383.07/322.02) GVRTH.HDRNSWTNGVNGGVvkREGSPDKGKALANMsgsSAMTNGGSASFM.DVDSQPPGGSKFNDLPEEIQhitADI.MPLSLLLTRLSQwTHSKLQD..EIAYLA.SKPLPQPV.LNGNTSHQSADNHDT....SQESLEKKVHLlnflqDMhSKWVKTLVITEwsKKAAQVGALiDI........RVHLLTKQAHYQ.ELFWELIRMKQDlhWAKVPGPDLKTAleVLTTGQAPWMpELGYIEPPPITweeKEAFIDNINTM.LSVRLTF.....DE..HEK.IPAPFRDYNIANGRVTFKAKGE
746- 1027 (371.63/239.57) GVRTHtGDQEGPANATAAQV..RRDTPAKIRAEARL...TVIDRSKFKSLRgNVDHDVVYNHRTGQFSLKLR...ADMgTPVVDLLADRVQ.ALERLMEfvEAIRLAgSNAIPQSVaLREVVFTYSNDPAETvsnpPQGPRAWSVHL.....DL.PKGAKVILTLE..KGNPHMRAL.DMlqemaqstKTELLPSYLPFSlPLYRVLDRIEDE..WDNIAAKNAGSV..AIVVKAAEWV.TVRFKLPAPTT...RRLLCLDIRTMgRKGRLLWhvkrtDEkgHERpLNGPQDEFDTLLQRSVWHAHGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 78.68| 24| 39| 288| 312| 4
---------------------------------------------------------------------------
288- 312 (37.95/30.24) EVDLTIGDEDFEQQFWFIDfRFLFT
329- 352 (40.74/26.90) KINIILGNEGLAGCYKYLH.EFVLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.99| 20| 22| 1067| 1087| 5
---------------------------------------------------------------------------
1067- 1087 (34.16/18.77) ITAPHPGGGVQDV.KQSP.qQPP
1090- 1112 (26.83/10.14) LVVTQATQAAQGIpPQRPkqQPP
---------------------------------------------------------------------------
|