<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27495

Description "WGS project CABT00000000 data, contig 2.1"
SequenceMTSRPPLGVQQRQPQQRKLSGPALSQQRSLSQPQAQAQAQQIQQQQLQQQHQHQHFQPPQQQQQQLQQQYDASSYLPPPPPSVRTNNNHNNFNQNNTLNTTFPPEFGQDPASIVSPADPSGSSPALSVGGVGSRHGTQRRGGSRLRLELSHNDPSNAFSSPTVIESPGLMEPHKQYSSMAHLMMPLADGSDLGEMSPHHHHHHQLSIPPQHLDADVPIPFPQRRPKAVPEHSRREQPPPPPNPARKDTRPKPYTIELPAAAPRYRIRGRNDGQGGQGRSSALATASSSSTTGSSATANYGCADFFPWSGTAGNHPEDQFNDGAIKNGYYEKRIVEPETQSAKTVLFHGLKQRSGLNALSIFFAGVLWHRRNAGQVTAPSTFKPPPRVTLTDTKKEVWLKDLANSAIPLRKLSRSIPHGVRNKVLLDQCLNKNVPIDRAVWLAKCVGTNELRTFRRLGKGNNASVLEGERKWLKDWTLVIEQFIERAFFSFGEQNWKAKVNYAIQLATHLYAEGLMDREHYLDWTVSSLESSHHSQLPMWIIIAQIYWKDLLRLRRYGRRLATALISHYHVIHAHEDRDIYVPLLSKLSHLLGTLMVATPENFVSPAVWVKYRDALKTCLPQGDEARHRSFAGINYRNEQLVASANRSQPAARIILVRHLDQVILEKPMPDEFPAQCWTVSKDKAALVRALLEWCTTLYRPGLAKVYVAHRILMHWSTLGLDVTFAVLNFMEGEVLEEKERKEALYHLVSELVRSGIFLVSQYIQWLIARGGLTDPQLVMPDGPPFSRLLAELPPQILGSSQRRSRDALLRRAGFNIADDAQDADMAIRRLRHALGLCVGVTDAVSMGRPLPIKNIARRIKDASRARKAEIASWLRNTVTGGELEHSTLNTFGQHGLSTRLFNSIRRIFEATQEFSVFADVLKMLTKCSNPEVLASIADTITRWPFEFAALGCFKNLFNILHSRLRDVVREQGIGARPLLASLAYLASRVPGMDEVATQLKSDLALSDRHNPVDACSPVSDNMVSRLQDNDGDLHEEVEKLLANGTSLDRNTMDRLFSAVIQRLQTYWAKGDEQQRVYGILLKRLRMFDLQHLDELMARWLLHVRGLNRRATILHLYPLLVSIGCLGLPAILATASETSNPPGAGNQRHPQPGVGTSQIVQTTFRTRYMQEVLQLFMAPVSSESLLTPEERYRFEILQEQAKKESPRELLGLIQLALAEYTYARAQNDLQDLPLDKEANQGRLLELLKRLVLKDPVGVAKALQIRGPDAQVAGWIDRMTTKLLVTAAGESTRVTFEQVLNLTNEFTLPFCHVKLLLSLSSNDQQQSAADSGERVPSNVELFMNAMEKSMDAQRVSWIGMLPSLSPDLTHHLKNQAQSRFLNLLPSSRNPPSMTLDRSTLQMRLQKAENFLAIMDTIIRGSGPMGLRQHQLVPVMVERFMDMLELLQTLTPLPSQAGGLGGWGGQCVSAAAASGDNHADLKSDILNHWLPLFLNFLTLHAQTFDTSKPGNEVRGRALIVCAGLIRELDLIHGPDFDTRQLGGRIFDLACVLVDNLAEDARLQCIQALKSPSDVKLRYIFSYQDNPHANLMLCHKERPTPMAMGNNGTGSPAPGTTPTHTPGVTPGQQATGPQNAGGGGGGGGGNGGGYFSLPGHTQQAQAQGWHAAQQQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQGGTGPMPSPAISINTNLTHLNLGNNSNPPTPSPMNPARPAMVMVANLWGGYSCVSTMGGSQERLTPFNFRQWEMLSEPTSQVGENDTAVNLMLFESRKVQ
Length1841
PositionKinase
OrganismSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Sordaria.
Aromaticity0.06
Grand average of hydropathy-0.511
Instability index56.95
Isoelectric point9.12
Molecular weight205639.71
Publications
PubMed=20386741

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27495
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     195.33|      15|      15|    1670|    1684|       1
---------------------------------------------------------------------------
   41-   55 (30.96/ 8.58)	QIQQQQLQQQHQHQH
 1663- 1677 (31.60/ 8.88)	AAQQQQLQQQQQQQQ
 1686- 1699 (31.17/ 8.68)	.QQQQQQQQQQQQQQ
 1700- 1714 (38.02/11.85)	QQQQQQQQQQQQQQQ
 1715- 1729 (38.02/11.85)	QQQQQQQQQQQQQQQ
 1730- 1741 (25.56/ 6.08)	QQQQQQQQQQQQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.28|      21|      21|     209|     229|       2
---------------------------------------------------------------------------
  209-  229 (40.47/23.27)	PQHLDADV.PIPFPQRRPKAVP
  241-  262 (34.81/18.91)	PNPARKDTrPKPYTIELPAAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.14|      16|      21|     676|     696|       3
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  676-  695 (24.07/25.39)	CwtvsKDKAALV....RALLEWCT
  698-  717 (25.08/ 9.67)	Y....RPGLAKVyvahRILMHWST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.65|      19|      21|    1601|    1619|       5
---------------------------------------------------------------------------
 1601- 1619 (37.72/21.24)	GNNGTGS.PAPG.TTPTHTPG
 1623- 1636 (25.53/11.28)	GQQATGP.QNAG.GG.....G
 1640- 1660 (26.40/12.00)	GGNGGGYfSLPGhTQQAQAQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.39|      18|      21|     969|     989|       6
---------------------------------------------------------------------------
  968-  988 (20.70/23.16)	VReqGIG..ARPLLASLAyLASR
  989- 1008 (26.69/15.11)	VP..GMDevATQLKSDLA.LSDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.28|      13|      20|       3|      15|       7
---------------------------------------------------------------------------
    3-   15 (27.50/12.95)	SRPPLGVQQR...QPQ
   20-   34 (19.75/ 6.81)	SGPALS.QQRslsQPQ
 1138- 1150 (27.03/12.58)	SNPPGAGNQR...HPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.76|      14|      20|     344|     361|       8
---------------------------------------------------------------------------
  354-  371 (16.00/ 9.88)	GLNALSIFfagVlWH..RRN
  407-  422 (17.76/ 8.41)	PLRKLSRS...I.PHgvRNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.66|      18|      22|     168|     185|       9
---------------------------------------------------------------------------
  153-  167 (19.20/ 6.96)	...DPSNAFSSPTVIESP
  168-  185 (34.66/18.43)	GLMEPHKQYSSMAHLMMP
  193-  208 (31.80/16.31)	GEMSPHHHHHH..QLSIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.19|      20|      20|      62|      81|      10
---------------------------------------------------------------------------
   58-   79 (32.34/16.60)	PP....qqQQQQLQQQYDASSYLPPP
   80-  104 (26.81/12.28)	PPsvrtnnNHNNFNQNNTLNTTFPP.
 1749- 1771 (24.04/10.10)	SPaisintNLTHLNLGNNSN...PPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.50|      10|      19|     423|     432|      11
---------------------------------------------------------------------------
  423-  432 (17.97/11.63)	VLLDQCLNKN
  439-  448 (19.53/13.33)	VWLAKCVGTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.41|      14|      19|    1053|    1066|      12
---------------------------------------------------------------------------
 1053- 1066 (22.89/16.10)	DRLFSAVIQRLQTY
 1074- 1087 (23.52/16.79)	QRVYGILLKRLRMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.71|      14|      19|     775|     789|      13
---------------------------------------------------------------------------
  775-  789 (23.80/14.73)	PQlVMPDGPPFSR..LL
  794-  809 (19.91/ 7.45)	PQ.ILGSSQRRSRdaLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.18|      23|      27|    1360|    1382|      16
---------------------------------------------------------------------------
 1367- 1391 (34.06/18.25)	THHLKNQAQSRFLNLL...PSS..rnPP.SM
 1397- 1424 (25.16/11.40)	TLQMRLQKAENFLAIM...DTIirgsGPmGL
 1426- 1449 (25.97/12.02)	QHQLVPVMVERFMDMLellQTL....TP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.03|      14|      15|     913|     926|      17
---------------------------------------------------------------------------
  913-  926 (22.09/14.90)	EFSVFADVLKMLTK
  929-  942 (21.94/14.75)	NPEVLASIADTITR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.49|      15|      16|     842|     857|      18
---------------------------------------------------------------------------
  842-  857 (22.65/16.98)	DAvSMGRPLPIKNIAR
  861-  875 (25.84/14.66)	DA.SRARKAEIASWLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.61|      14|      20|    1509|    1528|      20
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 1509- 1525 (17.37/25.50)	EVRGRALivcAGLIREL
 1532- 1545 (25.23/11.50)	DFDTRQL...GGRIFDL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27495 with Med12 domain of Kingdom Fungi
Unable to open file!