<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27475

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSASFVPNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLAEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSLGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQKKRKYSASSGGLCEEETAAKVASWDFVEATQRTNCSCSRHKNLKPRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVAMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVIDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPVEDRIDSLSQSFPPQFQEAVEPTVYVGTAVNLEEDEASIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKASCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGPQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLPSGPAMPFIKESDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEVQYRCTCGFSAVMNRKFGNNSGLFLEDELDIVGRNTDCGKEAEKRFEALRATSAEHVNGGLKESEKLPDDLMLLLQDQCTNLFSPFGAADQDPFPKSGVINNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMANTGNANTPSATLASAASTTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQPSALQTAGISGESSSLPIQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQGTDRLLSTEAHEEVPNILQQPLALGYFVSTAKAGPLPNWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2174
PositionMiddle
OrganismCallithrix jacchus (White-tufted-ear marmoset)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Callitrichinae> Callithrix> Callithrix.
Aromaticity0.08
Grand average of hydropathy-0.396
Instability index52.26
Isoelectric point5.46
Molecular weight239551.88
Publications
PubMed=25243066

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl
GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl
GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27475
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     222.62|      60|      67|     916|     980|       1
---------------------------------------------------------------------------
  881-  908 (27.32/ 8.39)	................................KIE.VDEGFCSP..KPSEIK....DFSYVYKPENC..
  916-  979 (97.90/69.89)	MfAPLKTLPSQYLPPIkLPEECIYR.QSWTVGKLELLPSGPAMPfiKESDGS....NMDQEYGPAYTPQ
  986- 1049 (97.40/55.25)	M.PPSSAPPSNSGAGI.LPSPSTPRfPTPRTPRTPRTPRGAGGP..ASAQGSvkyeNSDL.YSPASTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.19|      33|      60|     463|     497|       2
---------------------------------------------------------------------------
  463-  497 (53.06/36.07)	EKSEKPQKRPLTPfhHRVSISDDVAMDTDSA..SQRL
  526-  560 (59.14/33.53)	EMANSPQPPPLSP..HPCDVIDEGVTKTPSTpqSQHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.77|      43|     282|       6|      52|       3
---------------------------------------------------------------------------
    6-   52 (80.61/66.60)	VPNGASLEDCHCNLFCLadltGIKWKRYVWQGPT.SAPILFPVT..EE....DP
  290-  339 (66.16/44.53)	IPTPSSLGSTHCSSSCL....GVHQVPASTRDPAmSSVTLTPPTspEEvqtvDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.57|      27|     492|    1054|    1080|       4
---------------------------------------------------------------------------
 1054- 1080 (46.68/28.31)	LNS.VEPATVPSIPEAHSLYVNLILSES
 1546- 1573 (44.89/26.89)	LNSgVSSNKLPSFPPFGSMNSNAAGSMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     336.26|      87|     289|     352|     440|       5
---------------------------------------------------------------------------
  352-  440 (145.52/93.74)	SDGFNSDSTSHHG.............GKIPRKLANHVVDRVWQE..CNMNRAQKKRKYSASSGGLCEEEtaAKVASWDFVEATQRTNCSCSRHKNLKPRNAGQQ
  570-  632 (71.56/39.32)	............................VPSKPVEDRIDSLSQSfpPQFQEAVEPTVYVGTAVNLEEDE..ASIA.WKYYKVPKKKDVEFLPPQ..........
  635-  725 (119.18/70.94)	SDKFKDDPVGPFGqesvtsvtelmvqCKKPLK....VSDELVQ.......QYQIKNQYLSAIASDAEQE..PKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.26|      43|     848|    1253|    1301|       6
---------------------------------------------------------------------------
 1253- 1301 (68.54/61.60)	EALVKSSCLHPWSkrndvSMQCSqDILRMLL....SLQPVLQD.AIQKKRTVRP
 2110- 2157 (69.72/46.01)	DELLHSKHSHPLD.....SNQTS.DVLRFVLeqynALSWLTCDpAIQDRRSCLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.25|      54|     725|     746|     818|       7
---------------------------------------------------------------------------
  746-  818 (79.46/81.83)	SLFS.PSIKqdAPRPTSHARPP...................STSLIYDSDLAVSYtdldnlfnsdedeltpgSKKSANGSDDKASCKESKTGN
 1472- 1545 (73.79/42.49)	SLLSqPNLV..APTSQSLITPPqmantgnantpsatlasaaSTTMTMTSGVAIST.................SVATANSTLTTASTSSSSSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.46|      31|     848|    1088|    1131|       8
---------------------------------------------------------------------------
 1096- 1131 (50.72/49.44)	CVCNMNIKGAdvGVYIPDptqEVQYRCTCGFSAVMN
 1913- 1943 (55.74/23.51)	CLVAMEPQGS..FVIMPD...SVSTGSVFGRSTTLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.52|      20|    1197|     217|     236|      21
---------------------------------------------------------------------------
  217-  236 (36.03/24.80)	LTGQAFKMSDSATK....KLIGEW
 1411- 1434 (29.50/18.88)	LTDGIMRVGSTASKklseKLVAEW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27475 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CSCSRHKNLKPRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVAMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVIDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPVEDRIDSLSQSFP
2) DLDNLFNSDEDELTPGSKKSANGSDDKASCKE
3) GPAMPFIKESDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
4) SPVHSPGSHYPHGGDVGKGQGTDRLLSTEAH
5) STLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQPSALQTAGISGESSSLPIQPHPDVSESTMDRDKVGIPTDGD
424
782
954
2022
1531
587
813
1039
2052
1629










Molecular Recognition Features






MoRF SequenceStartStop




NANANA