Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDADPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMDICSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPNSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALGPADLMEHHSGSQGPLLATGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKNKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSGQTKNSSQSGGKPGSSPITKHGLSSSSSSTKMKPQGKPSSLMNPLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGSEDPMDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN |
Length | 1580 |
Position | Middle |
Organism | Callithrix jacchus (White-tufted-ear marmoset) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Callitrichinae> Callithrix> Callithrix. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.680 |
Instability index | 52.69 |
Isoelectric point | 8.88 |
Molecular weight | 168465.15 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 ISS:UniProtKB nucleolus GO:0005730 ISS:UniProtKB nucleoplasm GO:0005654 IEA:Ensembl nucleus GO:0005634 ISS:UniProtKB |
GO - Biological Function | chromatin binding GO:0003682 ISS:UniProtKB DNA binding GO:0003677 IEA:Ensembl estrogen receptor binding GO:0030331 IEA:Ensembl LBD domain binding GO:0050693 IEA:Ensembl nuclear receptor coactivator activity GO:0030374 ISS:UniProtKB peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl promoter-specific chromatin binding GO:1990841 IEA:Ensembl protein-containing complex binding GO:0044877 IEA:Ensembl retinoic acid receptor binding GO:0042974 IEA:Ensembl thyroid hormone receptor binding GO:0046966 ISS:UniProtKB transcription coactivator activity GO:0003713 ISS:UniProtKB transcription coregulator activity GO:0003712 ISS:UniProtKB transcription corepressor activity GO:0003714 ISS:UniProtKB vitamin D receptor binding GO:0042809 IEA:Ensembl |
GO - Biological Process | androgen biosynthetic process GO:0006702 ISS:UniProtKB angiogenesis GO:0001525 ISS:UniProtKB animal organ regeneration GO:0031100 IEA:Ensembl brain development GO:0007420 IEA:Ensembl cell morphogenesis GO:0000902 ISS:UniProtKB cellular response to epidermal growth factor stimulus GO:0071364 ISS:UniProtKB cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl cellular response to thyroid hormone stimulus GO:0097067 IEA:Ensembl embryonic heart tube development GO:0035050 IEA:Ensembl embryonic hemopoiesis GO:0035162 IEA:Ensembl embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl embryonic placenta development GO:0001892 IEA:Ensembl enucleate erythrocyte development GO:0048822 IEA:Ensembl epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA:Ensembl erythrocyte development GO:0048821 ISS:UniProtKB fat cell differentiation GO:0045444 IEA:Ensembl intracellular steroid hormone receptor signaling pathway GO:0030518 ISS:UniProtKB keratinocyte differentiation GO:0030216 ISS:UniProtKB lactation GO:0007595 IEA:Ensembl lens development in camera-type eye GO:0002088 ISS:UniProtKB liver development GO:0001889 IEA:Ensembl mammary gland branching involved in pregnancy GO:0060745 IEA:Ensembl mammary gland branching involved in thelarche GO:0060744 IEA:Ensembl megakaryocyte development GO:0035855 ISS:UniProtKB monocyte differentiation GO:0030224 IEA:Ensembl mRNA transcription by RNA polymerase II GO:0042789 ISS:UniProtKB negative regulation of apoptotic process GO:0043066 ISS:UniProtKB negative regulation of keratinocyte proliferation GO:0010839 ISS:UniProtKB negative regulation of neuron differentiation GO:0045665 ISS:UniProtKB negative regulation of transcription by RNA polymerase II GO:0000122 ISS:UniProtKB peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl positive regulation of gene expression GO:0010628 ISS:UniProtKB positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl positive regulation of keratinocyte differentiation GO:0045618 ISS:UniProtKB positive regulation of transcription by RNA polymerase II GO:0045944 ISS:UniProtKB positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 ISS:UniProtKB protein import into nucleus GO:0006606 IEA:Ensembl regulation of RNA biosynthetic process GO:2001141 ISS:UniProtKB regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl retinal pigment epithelium development GO:0003406 IEA:Ensembl thyroid hormone generation GO:0006590 IEA:Ensembl thyroid hormone mediated signaling pathway GO:0002154 ISS:UniProtKB ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl |
Binary Interactions |
Repeats | >MDP27450 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 9| 445.22| 50| 50| 1069| 1118| 1 --------------------------------------------------------------------------- 977- 1033 (44.56/ 8.89) GTSNSTLSGPGLDSKPGKRSrtpsndGKNKDKPPKRKKADTE..GK..SPShS.........S..SNRP..FT.P 1034- 1076 (44.25/ 8.77) P......TSTG.....GSKS......PGSSGRSQTPPGVATPpiPKitIQI.P.........K..GTVM..VG.K 1077- 1127 (72.93/19.83) PSSHSQYTSSGSVSSSGSKS......HHSHSSSSSSSSASTS..GK..MKS.S.........KseGSSS...S.K 1128- 1178 (52.86/12.10) LSS.SIYSSQGS.SGSGQTK......NSSQSGGKPGSSPITK.hGL..SSS.S.........S..STKMkpQG.K 1179- 1216 (41.30/ 7.64) PSSLMNPLSKPNISPSHSRP.......PGGSDKLASPMKPVP..G............................tP 1217- 1258 (45.39/ 9.21) PSSKAK....SPISSGSGGS......HMSGTSSS.......S..G...MKS.S....sglgsS..GS.L..SQ.K 1261- 1318 (53.04/12.17) PSSNSCTASSSSFSSSGSSM......SSSQNQHGSSKGKSPS..RN..KKP.SltavidklkH..GVVT..SG.. 1319- 1358 (41.22/ 7.60) PGSEDPM..DGQMGVSTNSS......SHPMSSKHNMSGGEFQ..GK..REK.S...................... 1457- 1504 (49.67/10.87) PQNLDSESESG..SSIAEKS......YQNSPSSDDGIRPLPE..YS..TEK.H.........K..KHKK..EK.K --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 208.08| 48| 50| 146| 193| 2 --------------------------------------------------------------------------- 146- 193 (81.59/49.36) NFD.EFSKHLKGLVNLYNL..........P..GDNKLKTKMYLALQSLEQ.DLSKMAIMYWK 196- 244 (70.55/41.57) NAG.PLDKILHGSVG.YLT..........PrsGGHLMNLKYYVSPSDLLD.DKTASPIILHE 250- 306 (55.94/31.27) SLGmNASVTIEGTSAMYKLpiaplimgshP..VDNKW.TPSFSSITSANSvDLP..ACFFLK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 479.34| 105| 117| 535| 651| 3 --------------------------------------------------------------------------- 540- 633 (161.69/74.31) ...........LP..PAS..SPGYGMT.TGNNPMSGTTTPTNTFPGGP.....ITTLFNMSMSI...KDRHESVGHGE......D..F.SK......V.SQ.....NPILTSLLQITGNGGST..IGSSP....TPPH..H.....TPPPVS 640- 757 (123.31/59.17) KNHPMLMNLLK..dnPAQdfSTLYGSS.PLERQNSSSGSPRMDICSGS.....NKTKKKKSSRLppdKPKHQT...ED......D..F.QRelfsmdVdSQ.....NPIFDV..NMTADTLDTphITPAPsqcsTPPT..T.....YPQPVP 758- 868 (107.75/41.65) HPQPSIQRMVRLS..SSD..SIGPDVT....DILSDIAEEASKLPSTSddcpaIGT......PL...RDSSSS.GHSQ......StlFdSD......V.FQtnnneNPYTDPADLIADAAGSP..NSDSP....T.NHffHdgvdfNPD... 870- 950 (86.59/32.02) ...........LN..SQS..QSGFGEEyFDESSQSGDNDDFKGFASQA.....LNTL.GVPMLG...GDNGETKFKGNnqadtvD..F.SI......I.S...............V...AGKA..LGPAD....LMEH..H........... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.03| 20| 50| 328| 358| 4 --------------------------------------------------------------------------- 336- 356 (32.34/38.61) YVPLYELITQFELSKDAdPIP 364- 383 (39.70/14.30) YAALPGQQHCYFLNKDA.PLP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 55.56| 17| 18| 1417| 1433| 6 --------------------------------------------------------------------------- 1415- 1431 (29.15/12.28) ES..SGEGLRPQMASKNYG 1432- 1450 (26.41/10.34) SPliSGSTPKHERGSPSHS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 121.30| 39| 53| 396| 438| 7 --------------------------------------------------------------------------- 396- 424 (37.02/27.92) ........................ITF.....QHPGRVPLILNLIRHQVAYNTLIgSC 428- 477 (53.82/41.98) TILKEDSPGLLqfevcplsesrfsVSF.....QHPVNDSLV..CVVMDVQDSTHV.SC 478- 514 (30.46/12.81) KLYKGLSDALI...........ctDDFiakvvQRCMSIPVTMRAIRRK.......... --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYFD 2) IKAKVTLQ 3) IRPLPEYSTEKHKKHKKEKKKVKDKDRDR 4) KITIQIPK 5) KPSLTAVIDKLKHG 6) RLSPDFMIGEEDDDLMDV 7) VAKIIISKH | 878 1404 1485 1062 1300 1558 1389 | 884 1411 1513 1069 1313 1575 1397 |
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