<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27447

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTMSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDAPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSEKWWHSYCLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRPSKIPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFMGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSTFLPQVEGTRKPQEPPISLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSTTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGSIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYAAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRSSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPSRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2210
PositionMiddle
OrganismMacaca mulatta (Rhesus macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.382
Instability index58.12
Isoelectric point5.65
Molecular weight242643.97
Publications
PubMed=17431167
PubMed=25319552

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27447
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.78|      21|      28|    1595|    1620|       1
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 1600- 1620 (39.61/14.43)	STTSSSGFSGSVG....GQN...PSTGG
 1622- 1649 (29.17/ 7.49)	STDRTQGSIGCGGdtdpGQSssqPSQDG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     507.08|     107|     112|     820|     926|       2
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  526-  618 (108.38/41.69)	..........DKQMAV.PSRN.TSKQMNLNPMD.SP.........HSPISPLP.PTLSPQPRGQETesldPPS.....VPVNPAL.....Y.GN..GLEL.QQLstlddrTVLV...GQRLPL......MAEVS......ETALY
  619-  738 (130.21/51.53)	CGIRPSNPesSEKWWHSYCLP.PSD....DAEF.RPpelQGErcDAKMEVNSE.STA..LQRLLAQ....PNKrfkiwQDKQPQMQP.LHF.LDplPLSQ.QPG......DSLG...EVNDPYtfedgdIKYIFTANKKCKQGTE
  820-  918 (156.15/63.23)	..........DELGAVSPALR.PSKIPTVGTED.RP...LGK..DGRAAVPYP.PTVADLQRMFPT....PPS.....LEQHPAFSPVMNY.KD..GISS.ETV......TALG...MMESPM......VSMVSTQLTEFKMEVE
  919- 1019 (112.34/43.47)	DGLGSPKP..EEIKDFSYVHKvPSFQPFMGSSMfAP...LKM.lPSHCLLPLKiPDACLFRPSWAI....PPK.....IEQLP.MPPAATFiRD..GYNNvPSV......GSLAdpdYLNTPQ......MN..............
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     236.92|      74|    1266|     156|     235|       3
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  156-  235 (114.53/112.27)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVSPYgLNGTLTGQAykmSDPATR.KL
 1425- 1501 (122.39/93.02)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQklTDELVSEW.FNQPWSGEE...NDNHSRlKL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.01|      25|      26|    1526|    1550|       4
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 1041- 1065 (26.20/ 7.74)	PatPRFSVPtPRTPRTPRTPRGGGT...
 1526- 1550 (48.08/21.07)	P..PKYQTP.PAAAQGQATPGNAGPLAP
 1554- 1573 (27.73/ 8.67)	......AAP.PAGSAFNPT.SNSSTTNP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.14|      23|      26|    1740|    1765|       5
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 1740- 1765 (38.99/31.28)	QvfyIQYLKSM..AFSVYCQCR...RPLPTQ
 1767- 1794 (30.15/15.51)	H...IKSLTGFgpAASIEMTLKnpeRPSPIQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2068|    2095|       6
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 2068- 2095 (37.05/26.52)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2098- 2126 (44.88/23.06)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.82|      26|      28|    1858|    1884|       7
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 1858- 1884 (42.51/29.57)	IALPSRSRRSkVSAR..KIGLQKLWEWCI
 1887- 1914 (43.32/25.59)	VQMTSLPWRV.VIGRlgRLGHGELKDWSI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.13|      20|      28|    1132|    1158|       8
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 1132- 1151 (40.30/35.56)	CICACNMNIK.GADVGLYIPD
 1162- 1182 (33.83/14.09)	CGFSAIMNRKlGYNSGLFLED
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.63|      16|      23|    1699|    1716|       9
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 1699- 1716 (26.60/24.39)	WLLSLMRC.YteMLDNLPE
 1722- 1738 (26.03/16.12)	FILQIVPCqY..MLQTMKD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.95|      25|      26|      60|      84|      11
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   60-   84 (48.05/28.90)	FIRCLQANLLCVWRRDVKPDCKELW
   86-  110 (47.90/28.79)	FWWGDEPNLVGVIHHELQVVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.45|      54|     913|     399|     490|      12
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  321-  377 (94.42/73.68)	CGM.PLTPPTSPEQailGESGGMQSAASHLVSQDGGMITMHSPKRSGKIP..PKLHNHMV
  434-  490 (90.03/39.02)	CAVgPNRPPTMSQP...GFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQkrPLIPFHHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.29|      17|      17|    1234|    1250|      13
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 1234- 1250 (30.27/16.25)	TQPFASLSFLDYISSNN
 1253- 1269 (33.02/18.40)	TLPCVSWSYDRVQADNN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.04|      19|    1265|     389|     417|      14
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  381-  401 (28.47/33.70)	WKecILNRTQSKRSQMSTPTL
  412-  430 (36.57/16.71)	WD..FVDPTQRVSCSCSRHKL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.55|      18|      22|    1340|    1357|      18
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 1340- 1357 (33.04/16.68)	KKRTGRTWENIQHVQGPL
 1363- 1380 (32.51/16.30)	HKMAGRGTYGSEESPEPL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.28|      11|      24|    2030|    2041|      19
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 2030- 2041 (17.73/12.57)	PFPDDmDNDIGI
 2057- 2067 (21.55/10.06)	PSPGS.PSGIGV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27447 with Med13 domain of Kingdom Metazoa
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