<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27442

Description Uncharacterized protein
SequenceMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRNWQKLIEPVAQNEAVPRGLPNPAGSANGGAHNCRQEGSPATVAGPKPANEFKNRNDIQKLNSPKAEKAGNRKRKGDHRDGHQGPPSKVSKASHEPLQNSSPLPTNGIGGSPESFPSPPEAGTLPGPEGSWTDLGENDKHSKIPVNAVRPHTSSPGPGKPSSTCSQGKAAGLQPLDKPEEAAGPHQPKSPLCSFSPRNARPETSVRQHSTCAPKGSVPSPSRRPQVLDPSRAVSSPPPPVATKRLEAGQQPGPEASQPWQEHLSSESHHRHPAGTPLQPPAPGCKVSLPPGEPPMLRIGFSPDAASKMDSDDAASGSDSKKKKRYRPKDYTVNLEGQVVEGGVKPVRLKERKLTFDPMTGQIKPLTHKESLQVDIPAVAEQHRTEPDPQEQKSNLPSPFEQTNWKELSRNEIIQSYLNRQSSLLSSSGVQTPGAHYFMNEYLKQEESTRREARKTHVLVPDSRAADLPGVSREVTGDDLNRIQEGHWPGVNGCYDTQGNWYDWTQCISLDPHGDDGKLNVLPYVCLD
Length577
PositionUnknown
OrganismOrnithorhynchus anatinus (Duckbill platypus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Monotremata> Ornithorhynchidae> Ornithorhynchus.
Aromaticity0.04
Grand average of hydropathy-0.956
Instability index57.32
Isoelectric point8.94
Molecular weight62743.39
Publications
PubMed=18464734

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27442
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.92|      22|      22|      89|     110|       1
---------------------------------------------------------------------------
   89-  107 (28.38/11.09)	.....SP.ATV..........AGPKPANEFKNRND
  108-  130 (23.15/ 7.69)	IQKlnSPkAEK..........AGNRKRK..GDHRD
  131-  163 (24.40/ 8.51)	GHQ.gPP.SKVskasheplqnSSPLPTNGIGGSPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     160.68|      37|     125|     170|     206|       2
---------------------------------------------------------------------------
  170-  206 (69.75/28.30)	E.AGTLP..GPEGS..WTDLGENDKHSKI....PVNA.VRPHTSSPG
  218-  254 (34.26/10.57)	KaAGLQPldKPEEA.....AGPHQPKSPLcsfsPRNA..RPETS...
  296-  333 (56.66/21.76)	E.AGQQP..GPEASqpWQEHLSSESHHRH....PAGTpLQP..PAPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.73|      21|     229|     266|     286|       3
---------------------------------------------------------------------------
  266-  286 (38.49/19.43)	SVPSPSRRPQVLDP.SRAVSSP
  497-  518 (32.25/15.22)	STRREARKTHVLVPdSRAADLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.95|      16|      17|     391|     407|       4
---------------------------------------------------------------------------
  391-  407 (25.28/19.35)	GGVKPVRLKErKLTFD.P
  410-  426 (25.67/14.50)	GQIKPLTHKE.SLQVDiP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27442 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NWQKLIEPVAQNEAVPRGLPNPAGSANGGAHNCRQEGSPATVAGPKPANEFKNRNDIQKLNSPKAEKAGNRKRKGDHRDGHQGPPSKVSKASHEPLQNSSPLPTNGIGGSPESFPSPPEAGTLPGPEGSWTDLGENDKHSKIPVNAVRPHTSSPGPGKPSSTCSQGKAAGLQPLDKPEEAAGPHQPKSPLCSFSPRNARPETSVRQHSTCAPKGSVPSPSRRPQVLDPSRAVSSPPPPVATKRLEAGQQPGPEASQPWQEHLSSESHHRHPAGTPLQPPAPGCKVSLPPGEPPMLRIGFSPDAASKMDSDDAASGSDSKKKKRYRPKDYTVNLEGQVVEGGVKPVRLKERKLTFDPMTGQIKPLTHKESLQVDIPAVAEQHRTEPDPQEQKSNLPSPFEQTNW
2) TRREARKTHVLVPDSRAADLPGVSREVTGDDLNRI
52
498
454
532










Molecular Recognition Features






MoRF SequenceStartStop




1) ATKRL
2) SKKKKRYR
291
369
295
376