<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27419

Description Mediator of RNA polymerase II transcription subunit 1
SequenceESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGALVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKANNQADTVDFSIISVAGKALGPADLMEHHSGSQGPLMTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYASQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1574
PositionMiddle
OrganismMacaca mulatta (Rhesus macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.04
Grand average of hydropathy-0.671
Instability index54.41
Isoelectric point8.91
Molecular weight167665.32
Publications
PubMed=17431167

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	ISS:UniProtKB
nucleolus	GO:0005730	ISS:UniProtKB
nucleus	GO:0005634	ISS:UniProtKB

GO - Biological Function
chromatin binding	GO:0003682	ISS:UniProtKB
nuclear receptor coactivator activity	GO:0030374	ISS:UniProtKB
retinoic acid receptor binding	GO:0042974	IBA:GO_Central
thyroid hormone receptor binding	GO:0046966	ISS:UniProtKB
transcription coactivator activity	GO:0003713	ISS:UniProtKB
transcription coregulator activity	GO:0003712	ISS:UniProtKB
transcription corepressor activity	GO:0003714	ISS:UniProtKB
vitamin D receptor binding	GO:0042809	IBA:GO_Central

GO - Biological Process
androgen biosynthetic process	GO:0006702	ISS:UniProtKB
angiogenesis	GO:0001525	ISS:UniProtKB
cell morphogenesis	GO:0000902	ISS:UniProtKB
cellular response to epidermal growth factor stimulus	GO:0071364	ISS:UniProtKB
cellular response to thyroid hormone stimulus	GO:0097067	IBA:GO_Central
erythrocyte development	GO:0048821	ISS:UniProtKB
intracellular steroid hormone receptor signaling pathway	GO:0030518	ISS:UniProtKB
keratinocyte differentiation	GO:0030216	ISS:UniProtKB
lens development in camera-type eye	GO:0002088	ISS:UniProtKB
megakaryocyte development	GO:0035855	ISS:UniProtKB
mRNA transcription by RNA polymerase II	GO:0042789	ISS:UniProtKB
negative regulation of apoptotic process	GO:0043066	ISS:UniProtKB
negative regulation of keratinocyte proliferation	GO:0010839	ISS:UniProtKB
negative regulation of neuron differentiation	GO:0045665	ISS:UniProtKB
negative regulation of transcription by RNA polymerase II	GO:0000122	ISS:UniProtKB
positive regulation of gene expression	GO:0010628	ISS:UniProtKB
positive regulation of keratinocyte differentiation	GO:0045618	ISS:UniProtKB
positive regulation of transcription by RNA polymerase II	GO:0045944	ISS:UniProtKB
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISS:UniProtKB
regulation of RNA biosynthetic process	GO:2001141	ISS:UniProtKB
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
thyroid hormone mediated signaling pathway	GO:0002154	ISS:UniProtKB









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27419
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1073.70|     156|     160|    1010|    1165|       1
---------------------------------------------------------------------------
  533-  680 (126.62/31.04)	........................................PPA.S.....SPGYG..MTT.GNN....PmsGT..TTP.....TNTFPGGPITtlfnmsmsikdrhesVGHGEDFSkvsqnpiltsllQI.......TGNGgsTIGSSPTPP........HHTPPPVSSMAGNTKN.HPMlmnllKD.NP....AQDFS...........TLY......G..SS..PLERQNSSSG.......SP.....RMEI.CSGSNKT.K
  687-  854 (171.80/45.09)	L..PPE.KPK..HQTeddfqrelfsmdvdSQNPifdvnMTADT.LDTPHITPAPS...QC.STP....P..TT..YPQPVPHPQPSIQR...M...............VRLSSSDS............IG.......PDVT..DILSDIAE.........EASKLPSTSDDCPAIG.TPL.....RD.SS....SSGHSQS.TLfD...SDVFQTNNNENpyTD..PADLIADAAGSP...SSDSPT...NHFF.HDG......
  860- 1011 (135.90/33.92)	.........DllNSQ..............SQSG.....FGEEY.FDESSQ....S..GDN.DDF....K..GF..ASQALN..TLGVP....M...............LGGDNGET............KFkannqadTVDF..SIISVAGKAlgpadlmeHHSGSQGPLMTTGDL..GKE.....KT.QKrvkeGNGTSNS.TL.A...GPGLDSKPGKR..SR..TPSNDGKSKDKP......PKR...KKAD.TEG......
 1012- 1164 (255.48/71.11)	.....K.SPS..HSS..............SNRP.....FTPPT.STGGSKSPGSS..GRS.QTP....P..GV..ATPPIPKITIQIPKGTVM...............VGKPSSHS............QY.......TSSG..SVSSSGSKS........HHSHSSSSSSSSASTS.GKM.....KS.SK....SEGSSSS.KL.S...SSMYASQGSSG..SS..QSKNSSQSGGKP...GSSPIT...KHGL.SSGSSST.K
 1165- 1317 (173.06/45.48)	MkpQGK..PS...SL..............MNPS.....LSKPNiSPSHSRPPGGS..DKL.ASPmkpvP..G....TPPSSK.....AKSPIS...............SGSGGSH.......................MSG..TSSSSGMK.............SSSGLGSSGSLS.QKT....pPS.SN....SCTASSS.SF.SssgSSMSSSQNQHG..SS..KGKSPSRN.KKP...SLTAVIdklKHGVvTSGPGGEdP
 1318- 1436 (123.49/30.06)	L..DGQmGVS..TNS..............SSHP.....MSSKH.NMSGGEFQGKR..EKS.DK.................DK.....SK.......................................................VSTSGSSV........DSSKKTSESKNVGSTGvAKI.....II.SK....HDGGSPSiKA.K...VTLQKPGESSG..EGlrPQMASSKNYGSPlisGSTP.....KH............
 1439- 1538 (87.34/18.82)	....G..SPS..HSK..............S.PA.....YTPQN.LDSESES.GSSiaEKSyQNS....P..SSddGIRPLPEYSTEKHKKHKK...............EKKKVKDK............DR.......DRDR..DKDRDKKKS........H..............S.IKP.....ESwSK....SPISSDQ.SL.S..........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.40|      19|      47|     298|     316|       2
---------------------------------------------------------------------------
  298-  316 (35.03/21.26)	KFPQPIPVSRA..FVQKL...QSC
  342-  365 (27.38/14.82)	KDPDPIPLNHNmrFYAALpgqQHC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.12|      44|     340|      93|     142|       3
---------------------------------------------------------------------------
   93-  142 (67.78/58.05)	CYITSDMFYVEVQlDPAGQ..LC...DVKVAHHgenpVSCpELVQQLREK..NFDEF
  435-  485 (68.34/39.80)	CPLSESRFSVSFQ.HPVNDslVCvvmDVQDSTH....VSC.KLYKGLSDAliCTDDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.14|      49|      50|     144|     192|       4
---------------------------------------------------------------------------
  144-  192 (83.09/53.54)	KHLKGLVNLYNL..........P..GDNKLKTKMYLALQSLEQ.DLSKMAIMYWKATNAGPL
  194-  243 (72.87/45.90)	KILHGSVG.YLT..........PrsGGHLMNLKYYVSPSDLLD.DKTASPIILHENNVSRSL
  249-  291 (29.17/13.28)	VTIEGTSAMYKLpiaplimgshP..VDNKW.TPSFSSITSANSvDL................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27419 with Med1 domain of Kingdom Metazoa
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