<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27414

Description Mediator complex subunit 14
SequenceLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGVTKDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYSCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHPGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSVEKLLIDSVHARSHQKLQELKSVLKGFNANENSFIETALPTLVIPILEPCDRSECLHIFVDLHSGMFQVMLYGLDQVTLDDMEKSVNDDMKRIVSWIQQLKFWLGQQRCKQSIKHLPTICSETLQLSNYTTHPVGSLSKNKLFIKLTRLPQYYIVVEMFDIPSCPTELEYKYHFLSVSFAEGDDSPVTALLLQQFKTNIEEPALDAKSGKQAKTGSKRKLSGDPCALDPKKPKGSGEMCAFNKVLAHFVAMCDTNMPFIGLRMELCNMEIPHQGVQVEGDGFSHAIRLLKIPPCKGTSEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSTREQGPTRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPEIPTHLNVFSEVRVYNYRKLILCYGSTKGSSISIQWNSAHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGADMMDSLISQLQPQQQAFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGIAIGPGTNFASPHGTIDPSSPYAMVSPSGRAGNWPGSPQVSGPSPATRITGMSPANPSLHSPVPDASHSPRAGTSSQTLPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKASVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1383
PositionTail
OrganismOrnithorhynchus anatinus (Duckbill platypus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Monotremata> Ornithorhynchidae> Ornithorhynchus.
Aromaticity0.07
Grand average of hydropathy-0.192
Instability index50.15
Isoelectric point8.84
Molecular weight153495.56
Publications
PubMed=18464734

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
stem cell population maintenance	GO:0019827	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27414
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     148.99|      29|      31|     981|    1009|       1
---------------------------------------------------------------------------
  915-  941 (38.91/16.89)	PPSPIGADMMD.....SLISQLQ.PQQQAF.PK..Q
  965-  998 (48.06/22.79)	PSMMHTQSPGNlhaasSPSGALRAPSPASFVPT..P
  999- 1030 (34.67/14.15)	PPSSHGIAIGPgtnfaSPHGTIDPSSPYAMVS....
 1061- 1088 (27.35/ 9.43)	.PSLHSPV..P.....DASHSPRAGTSSQTLPTnmP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.69|      12|      32|    1269|    1280|       2
---------------------------------------------------------------------------
 1269- 1280 (23.88/10.97)	LTIPPSAPPIAP
 1298- 1309 (22.80/10.13)	LTQKASVPPQEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     274.01|      92|     283|     410|     525|       4
---------------------------------------------------------------------------
  271-  372 (137.42/94.03)	WNQQV...LGRKTGTASV.HKVTIkidendVSKPLQI..FHDPPLPA.SDSKLVERAMKID..HLSVEKLLIDSVHARSHQKLQELkSVlkGFNANENSFIeTAL..PTLVIP
  423-  525 (136.60/120.22)	WIQQLkfwLGQQRCKQSIkHLPTI......CSETLQLsnYTTHPVGSlSKNKLFIKLTRLPqyYIVVEMFDIPSCPTELEYKYHFL.SV..SFAEGDDSPV.TALllQQFKTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.59|      12|     281|    1089|    1100|       5
---------------------------------------------------------------------------
 1049- 1060 (20.32/ 9.41)	PATRITGMSPAN
 1089- 1100 (23.28/11.95)	PPRKLPQRSWAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.49|      12|      38|    1176|    1187|       9
---------------------------------------------------------------------------
 1176- 1187 (22.11/14.35)	LKCRVALSP.KTN
 1214- 1226 (18.38/10.42)	FETRVAGPPfKAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.30|      11|      32|     135|     145|      11
---------------------------------------------------------------------------
  135-  145 (19.25/ 9.72)	DLPPQLANLTV
  170-  180 (20.05/10.45)	DVPWRLLKLEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.33|      10|      25|    1331|    1340|      14
---------------------------------------------------------------------------
 1331- 1340 (17.56/10.14)	PRQQNSSVAA
 1357- 1366 (19.77/12.42)	PRQGECTIFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.09|      19|     154|     222|     246|      15
---------------------------------------------------------------------------
  222-  246 (26.98/25.80)	DMYSCLHSFclslqLEvLHSQ..TLML
  378-  398 (32.11/22.90)	DRSECLHIF.....VD.LHSGmfQVML
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27414 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGADMMDSLISQLQPQQQAFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGIAIGPGTNFASPHGTIDPSSPYAMVSPSGRAGNWPGSPQVSGPSPATRITGMSPANPSLHSPVPDASHSPRAGTSSQTLPTNMPPPRKLPQRSWA
901
1099










Molecular Recognition Features






MoRF SequenceStartStop




NANANA