<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27411

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length722
PositionTail
OrganismMacaca mulatta (Rhesus macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.03
Grand average of hydropathy-0.739
Instability index89.50
Isoelectric point9.50
Molecular weight79597.48
Publications
PubMed=17431167

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27411
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     318.64|      42|      42|     153|     194|       1
---------------------------------------------------------------------------
  130-  164 (60.82/ 9.51)	QQVALQQ......QQQQQQFQQQQQAA..L.......qQQQQQQQQQFQA
  165-  207 (73.00/13.23)	QQSAMQQQFQAVVQQQQQQLQQQQQQQQHL.......iKLHHQNQQQIQQ
  208-  241 (60.42/ 9.38)	QQQQLQRMAQLQLQQQQQQQQQQQQ................QQQQQALQA
  246-  290 (70.63/12.51)	QQPPMQQPQPPPTQALPQQLQQMHHPQHHQ....pppqPQQPPVAQN.QP
  291-  339 (53.77/ 7.35)	SQLPPQSQTQPLVSQAQALPGQMLYTQPPLkfvrapmvVQQPPVQPQVQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.96|      16|      19|     355|     373|       2
---------------------------------------------------------------------------
  355-  372 (26.51/ 8.55)	PGvqVSQSSLPMLSSPSP
  394-  409 (24.45/ 6.31)	QP..GSQPNSNVSSGPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.07|      18|      21|      60|      80|       4
---------------------------------------------------------------------------
   60-   77 (35.27/13.43)	QSLTGGPAAGAAGIGMPP
   82-   98 (27.46/13.00)	QSLGGMGSLGAMGQPMS.
   99-  112 (23.34/ 7.59)	..LSGQPPPGTS..GMAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     198.34|      45|      45|     565|     609|       5
---------------------------------------------------------------------------
  418-  449 (42.07/14.39)	PSPQPSQSPVT...ART....PQNFSVPSPgPLNTPVNP..................
  534-  563 (29.75/ 8.01)	.........................AVPTP.P.PPPVPPTKQqylcQPLLDAVLANI
  564-  608 (77.25/32.59)	RSPVFNHSLYR...TFV....PAMTAIHGP.PITAPVVCTRK....RRLEDDERQSI
  609-  652 (49.27/18.11)	PS.VLQGEVARldpKFLvnldPSHCSNNG....TVHLI.C.......KLDDKDLPSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      59.01|      15|      28|     467|     482|       6
---------------------------------------------------------------------------
  467-  482 (22.29/18.91)	LDK....LKQLSKYIePLRR
  487-  502 (14.84/ 6.31)	IDKnedrKKDLSK....MKS
  504-  517 (21.88/12.89)	LDI....LTDPSKRC.PLK.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27411 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTAT
2) QQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
44
232
122
472










Molecular Recognition Features






MoRF SequenceStartStop




1) LKFVRA
320
325