<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27407
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MDLAYICEWEKCPKSNHCPSIPLVCAWSCRNLIAFTTDLKNEEEKVLLFVPLLLFQHPLFVWDPRVPSSNSPYRSRLNAREGSNSMLNPTQRRAELRGEVVSRTKLEWIKMEGVDFENRREISWERDGWKRSTHHLESEFIPFSGELHQIFLTPKLETHWKQLAEKQSSATQAANRSVYLKSNQIVLEVIIVVLRARYVPGVNMSAGICFPPNTSQDDIFCVCQAKEARVGLFSCRGTEEATPTKTPHSRLQILGLDDPSQVLLCASNQISSIVECWSLRKEGLPVNNIFQQISPVAVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNIDLKVANDTKFYPGLGLALAFHDGSVHIIHRLSLQTMAMFYGSSSQRSVDEQALKRQRTASPSVHYKAMQLSWTSLALVGIDNHGKLSMLRISPSMGHILDMNMSLCHLLFLLEYCMVTGYDWWDILLHVQPNMVQMLVEKLHEEYMRQNAALQQVRRPPTWGDRTRQRE |
Length | 504 |
Position | Tail |
Organism | Ornithorhynchus anatinus (Duckbill platypus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Monotremata> Ornithorhynchidae> Ornithorhynchus.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.232 |
Instability index | 51.48 |
Isoelectric point | 8.49 |
Molecular weight | 57516.78 |
Publications | PubMed=18464734
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | catalytic activity GO:0003824 IEA:InterPro
|
GO - Biological Process | positive regulation of transcription, DNA-templated GO:0045893 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP27407
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 80.65| 25| 29| 288| 316| 1
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291- 316 (39.90/35.87) QQISPVAVgDKQPMILKWRILSATND
318- 342 (40.75/22.14) DRVSAVAL.PKLPISLTNIDLKVAND
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 91.81| 28| 30| 383| 410| 2
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383- 410 (46.54/37.05) VDEQA.LKRQRTASPSVHYKAMQLSWTSL
415- 443 (45.27/35.82) IDNHGkLSMLRISPSMGHILDMNMSLCHL
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