<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27403

Description Mediator complex subunit 12 like
SequenceQDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHVASSAGEGPVPVPPDVEQAMKQWEYNEKLAFHLFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLAAHSPHMMIGPSSSSIGAPSPGAPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDSKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWAHQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSEYEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTQPRSPAGDNADEHYPKDHDVKMEIFSPMPGESCENASPSLGRRMSLNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSSTETGVGDEGQKARKSKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVANPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSVLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTMRGLRRDGNADDIWTASQHSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECPEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSSSGMGLFNPNGVGSTDASSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDTKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQARGDGLQVSTKQKVSPWDLLEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPTPKPRSYYLEPLPLPPEEEEEEPSSPVSQEPERKSAELSDQGKTTADEEKKTKGRKRKTKSSSRADEYPQSSMYRAPPNYSPVSSQMMHHPQSALWGYNLMGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMRLLQQQQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQQPSGYVQQQASPYLQPLTGSQRLNHQSLQQSPLVGGGIDAVLTSTHPSLPSVPLPQDPMRPRQPQVRQQQRLLQVRGWEMQQPQQPPQPPQSQTLSLQAMQPQQPLFPRPGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVAPYGHPSHF
Length2115
PositionKinase
OrganismEquus caballus (Horse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Perissodactyla> Equidae> Equus.
Aromaticity0.07
Grand average of hydropathy-0.422
Instability index57.74
Isoelectric point7.75
Molecular weight236096.09
Publications
PubMed=19892987

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27403
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     112.06|      18|      18|    1849|    1866|       1
---------------------------------------------------------------------------
 1780- 1800 (23.73/ 6.86)	QS.....ALWGYNLMGQPQQPGfflQ
 1849- 1866 (34.58/13.24)	QQ.....QLIQMRLLQQQQQQQ...Q
 1892- 1914 (23.29/ 6.60)	AQarpspQLPQYPGLQQAQTMP...Q
 2034- 2051 (30.46/10.82)	QQ.....RLLQVRGWEMQQPQQ...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     199.46|      52|     152|    1052|    1130|       3
---------------------------------------------------------------------------
  840-  877 (37.83/ 9.86)	......................GSYTTglCVCIVAVLRRYHSC.LIlnPDQTAQVFEGL...CG.
  878-  923 (75.60/31.44)	VVKHVANPSECSSP...........ER..C.ILAYLYDLYVSCsHL..RSKFGDLF...SSACSK
 1069- 1128 (86.02/87.02)	VVQHVALPSLLAAAcgdadaepGARMT..CRLLLHLFRAPQAC.LL..PQATGKPFPGIRSSCDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.59|      44|     147|     457|     503|       4
---------------------------------------------------------------------------
  457-  503 (67.98/58.27)	AHQNKDnqEVAPNDEAV.VTLLCEWAV.SCKRS....GKHRAMAVAKLLeKRQ
  606-  655 (66.61/45.35)	AGDNAD..EHYPKDHDVkMEIFSPMPGeSCENAspslGRRMSLNGEKLL.KRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.15|      30|     255|     521|     551|       5
---------------------------------------------------------------------------
  521-  551 (46.39/34.60)	ESISS.ASLAGSSLPVFQNVLLRFlDTQAPSL
  778-  808 (49.76/32.51)	EQITSfASGTSYHLPLAHHIQLIF.DLMEPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.16|      18|     147|    1810|    1835|       6
---------------------------------------------------------------------------
 1608- 1636 (23.94/ 6.32)	MGSLIDTkgnkiagfdsiDKKQARGDGLQ
 1814- 1831 (32.22/31.18)	AGSFVPT...........NTKQALSNMLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.59|      33|      34|    1226|    1258|       7
---------------------------------------------------------------------------
 1226- 1251 (38.95/20.41)	..........HCLK....E.PERL..CTDKELILDPVLSNMQA
 1252- 1287 (44.61/24.51)	QKLLQLIcypHGIK....EcPEGD..NLQRQHI.KRILQNLEQ
 1433- 1467 (28.03/12.50)	QPFLSLV..lTCLKgqdeQ.REGLltSLQNQ..VNQILSN...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.03|      24|      27|     964|     988|      10
---------------------------------------------------------------------------
  964-  988 (40.04/31.16)	GKIlSD..NAANRYSFVCNTLMNVCMG
  993- 1018 (38.99/25.21)	GRI.NDiaNFSSELTACCTVLSSEWLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.35|      10|     181|    1802|    1812|      13
---------------------------------------------------------------------------
 1802- 1812 (15.17/10.89)	QSLTpGGSRLD
 1980- 1989 (19.18/ 8.11)	QPLT.GSQRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.06|      11|      32|     699|     709|      20
---------------------------------------------------------------------------
  699-  709 (20.75/14.65)	GVGKERDEARH
  731-  741 (20.30/14.15)	GVGDEGQKARK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.17|       9|     188|    1019|    1032|      23
---------------------------------------------------------------------------
  340-  348 (21.27/ 6.12)	LCCPSALVW
 1023- 1031 (21.89/ 9.17)	LCCSSNHVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.75|      21|      32|    1637|    1657|      27
---------------------------------------------------------------------------
 1637- 1657 (37.91/25.27)	VSTKQKVSPWD....LLEGQKNPAP
 1666- 1690 (31.84/19.88)	VRVDRKVIKYEeqhhLLLYHTHPTP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27403 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTPQQQAGSVVLSPTYNSRTYPAAHSNPALMERLRQMQQQPSGYVQQQASPYLQPLTGSQRLNHQSLQQSPLVGGGIDAVLTSTHPSLPSVPLPQDPMRPRQPQVRQQQRLLQVRGW
2) PRSYYLEPLPLPPEEEEEEPSSPVSQEPERKSAELSDQGKTTADEEKKTKGRKRKTKSSSRADEYPQSSMYRAPPNYSPVSSQMMHHPQSALWGYNLM
3) QPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAI
1928
1720
1822
2088
1817
1874










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGLLSYEQRPLKRPRLGPPDVY
2) RSYYLEPLPLP
1
1721
25
1731