<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27401

Description Mediator complex subunit 23
SequenceMESQLLSIFEEMVKTEIIEEAFAGMFMDTPEDERTKLISCLGAFRQYWSVLPQESHEQCVQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDSLEWERTQLWILTFKLIRKIIGGVDYKGVRDLLKVILEKIQTVPDTVSSAVVQQLLAAREVVAYILERNACLLPAYLAVTEVLKLYPEGKLPHWLLGDLVSDFVDSFRPTARISSICAFAGRCSLLPVVNNSGAICNSWKLDPLTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDITKPQSTHSFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMTDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGNVNIPLPGSNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKMAQAKSTFALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAGVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTIARATHVTDFFTGSESIQGTWCKDILQTIISFTPHNWALHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSLQGSPPLFLCLLWKMLLETDQINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEMLNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVNPPVQIQPQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHVDRPVTYLYNTLHYYEMQLRDRTNLKRKLVHAIIGSLKDNRPQGWCLSDTYLKFGMNPRDDNPWIPDDTYYCKLIGRLVDNILYSMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSILNSPSLTSETEWVGYPFQLFDFTACHKAYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLPEVLIPIVKTEYQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYEMLLNVDQCSAHLNFMDPICDFLYHMKYMFTGDSIKDQVEKIICNLRPALKLRLRHITHISTESAAPPPPPMNSGSPAPQPSQVPVSVPLTVTQ
Length1377
PositionTail
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Silurana.
Aromaticity0.10
Grand average of hydropathy-0.000
Instability index44.96
Isoelectric point6.77
Molecular weight157420.40
Publications
PubMed=20431018

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27401
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.95|      16|      66|      75|      97|       1
---------------------------------------------------------------------------
   75-   93 (21.32/30.75)	RISFLydClAMAVETGLLP
  217-  232 (31.62/14.38)	RISSI..C.AFAGRCSLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     927.59|     257|     721|     243|     513|       2
---------------------------------------------------------------------------
  243-  513 (417.98/318.10)	SWKLDplTLRFPLKGLLPYDKDlfEPQTAL...LRYVLEQ.....PYSRDMVCNMLGLNKQHKQRCPVLEDQLVDlvvYAME.RSETEEKFDDGGTSQLLwqhlsSQLIFFVLFQFASFphMVLSLHQKLAGR..GL...IKGRDHLMW.........VLLQFISGSIQKNALADFLPVMKLFDLLYPEKEC..IPVPDITKPQSTHSFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFL....QQSLRNKSLQM.TDYKIALL....CN.AYSTNSECFTLPMGVLVETIYGNGNVN....IP..LP
  829-  981 (162.32/99.95)	...................................................................................................................FADF..LVYEFSTSAGGQ..QLnkcIEMLNDMVWkynivtldrLILCLAMRSHEGNEAQVCYFIIQLL.LLKPNDFR..NRVSDFVKENSPEH......WLQNDWHTKHMNYHKKYP....EKLYFEGL....AEQV.NPPVQIqPQYLPIYF....GN.VCLRFLPVFDIVIHRFLELL.................
  984- 1240 (347.30/231.39)	SKSLE..TLLDHLGGLYKFHVD..RPVTYLyntLHYYEMQlrdrtNLKRKLVHAIIGSLKDNRPQGWCLSDTYLK...FGMNpRDDNPWIPDDTYYCKLI.....GRLVDNILYS..............MAGKspGP...FPNCD...W.........RFNEFPNPA....AHALHVTCVELMALAVPGKEVgnALLNVVLKSQPLVPRENITAW..MNAIGLIITA...LPEPYWIVLHDRIVsilnSPSLTSET.EW.VGYPFQLFdftaCHkAYSEMSCSYTLA...LAHAVWHHSSIGqlslIPkfLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     210.98|      56|     607|     699|     756|       3
---------------------------------------------------------------------------
   29-   56 (24.81/ 8.80)	..............................TPEDERTKLISCLGA.....FRQywSVLPQESH
  699-  756 (97.15/66.00)	HVTDFFTGsESIQGTWCKDI..LQTIISF.TPHNWALHTLSCFPAPlQAFFKQ..NNVPQESR
 1308- 1366 (89.02/52.43)	HMKYMFTG.DSIKDQVEKIIcnLRPALKLrLRHITHISTESAAPPP.PPMNSG..SPAPQPSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27401 with Med23 domain of Kingdom Metazoa
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