<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27400

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMTAAPASPQQIRDRLLQAIDPQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPAHQHEVALRGLAGATGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKATHDPLVPNSSPLPTNGISGSPESFPGSLDGSGHAGPEGSRLERGENDKHGGKIPINAVRPHTSSPGLSKPPGPCLQAKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQNLYVPKGSMPSPSPRPQTLDATQVPSPLPLAQPSTPPVRRPELLSSSESPVRWLEQPESHQRLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQPSRTELDKQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRRGARQLHVLVPQSPPTDLPGLTREVTQDDLNRIQASQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length600
PositionUnknown
OrganismCallithrix jacchus (White-tufted-ear marmoset)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Callitrichinae> Callithrix> Callithrix.
Aromaticity0.04
Grand average of hydropathy-0.873
Instability index64.10
Isoelectric point9.51
Molecular weight65569.89
Publications
PubMed=25243066

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27400
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     186.84|      40|      40|     119|     158|       1
---------------------------------------------------------------------------
  114-  150 (50.99/17.61)	....EVGAaGPPRSI....HDLK.......SRNDLQRL...PG..........QRLDRLGS.RKRR
  151-  193 (48.25/16.28)	GDQRDLGHpGPPPKVskatHDPL.......VPNS.SPL...PT..........NGIS..GSpESFP
  212-  260 (51.05/17.65)	GENDKHGGkIPINAV....RPHT.......SSPGLSKP...PGpclqakasvlQQLDRVD...ETP
  295-  338 (36.55/10.57)	......GS.MPSPSP....RPQTldatqvpSPLPLAQPstpPV..........RRPELLSS.SESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.82|      33|     129|     360|     408|       3
---------------------------------------------------------------------------
  265-  309 (55.59/13.89)	PKGP..PRCSFSPRNSRHE.......GSFARQQNLYVPKgsmpspsprpqtLDA
  362-  408 (43.23/41.78)	PAEPllSRAGFSPDSSKADsdaassgGSDSKKKKRYRPR.......dytvnLDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.10|      35|      62|     469|     506|       5
---------------------------------------------------------------------------
  469-  506 (53.07/46.07)	QSPfeQTNWKELSRnEIIQSYLSR.QSSLLSS.SGAQ.TPG
  534-  571 (53.03/34.20)	QSP..PTDLPGLTR.EVTQDDLNRiQASQWPGvNGCQdTQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.31|      21|     107|     339|     360|       6
---------------------------------------------------------------------------
  339-  360 (37.03/21.97)	VR.....WLEQPeSHQRLAGPGCKAGL
  443-  468 (31.27/14.17)	VRadspvHMEQP.SRTELDKQEAKASL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27400 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HEVALRGLAGATGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKATHDPLVPNSSPLPTNGISGSPESFPGSLDGSGHAGPEGSRLERGENDKHGGKIPINAVRPHTSSPGLSKPPGPCLQAKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQNLYVPKGSMPSPSPRPQTLDATQVPSPLPLAQPSTPPVRRPELLSSSESPVRWLEQPESHQRLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQPSRTELDKQEAKASLQSPFEQTNW
2) RRGARQLHVLVPQSPPTDLPGLTREVTQDDLNR
90
522
477
554










Molecular Recognition Features






MoRF SequenceStartStop




1) IRDRLL
2) KKKKRYRPRDYTVNLD
11
392
16
407