<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27398

Description Mediator complex subunit 14
SequenceMAPVQLENHQLVPPGGGGGGSGGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQTTLDDMEKSINDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLLYKYYFMSVNATDREDSPVMALLLQQFKENVQEVVFRTKAGKQPRTGTKRKLSDDPCPVEPKKTKRSGEMCAFNKILAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMTVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1454
PositionTail
OrganismEquus caballus (Horse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Perissodactyla> Equidae> Equus.
Aromaticity0.07
Grand average of hydropathy-0.189
Instability index52.53
Isoelectric point8.97
Molecular weight160688.80
Publications
PubMed=19892987

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27398
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     160.61|      32|      32|    1101|    1132|       1
---------------------------------------------------------------------------
 1011- 1057 (40.01/14.99)	K....QP.GSSGAY..P.......ltspptsyhstvnqSPSMMHTQSPGNlHAASSPSGAL
 1074- 1122 (47.94/19.60)	HgisiGP.GASFAS..P........hgtldpsspytmvSPSGRAGNWPGS.PQVSGPSPAT
 1123- 1153 (45.05/17.92)	R....MP.GMSPAN..P..................slhSPVPDASH...S.PR.AGTSSQT
 1154- 1208 (27.61/ 7.78)	.....MPtNMPPPRklPqrswaasiptilthsalnillLPSPTPGLVPGL.AGSYLCSPLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      31|     246|     275|       2
---------------------------------------------------------------------------
  246-  275 (48.89/29.64)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  276-  309 (45.75/27.29)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.88|      12|      31|    1340|    1351|       3
---------------------------------------------------------------------------
 1340- 1351 (23.85/11.66)	LTIPPSAPPIAP
 1369- 1380 (23.03/10.97)	LTQKTSVPPQEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.78|      31|      31|      66|      96|       4
---------------------------------------------------------------------------
   66-   96 (49.61/34.13)	LMVLTDLLPRKSDVERKIEIVQFASRTRQLF
   99-  129 (51.17/35.44)	LLALVKWANNAGKVEKCAMISSFLDQQAILF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.75|      12|      31|     359|     370|       5
---------------------------------------------------------------------------
  359-  370 (20.47/16.32)	IKIDENDVSKPL
  390-  401 (20.28/16.08)	MKIDHLSIEKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.10|      11|      31|     135|     145|       6
---------------------------------------------------------------------------
  135-  145 (16.90/10.33)	RLASLARDALV
  168-  178 (20.20/14.00)	RLPTCIRDKII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.75|      27|     504|     329|     355|       7
---------------------------------------------------------------------------
  329-  355 (50.37/29.85)	YHAGKCLSLSV.WN...QQ......VLGRKTGTASVH
  812-  848 (37.38/20.37)	YGTTKGSSISIqWNsihQKfhislgTVGPNSGCSNCH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.77|      26|     504|     445|     503|       8
---------------------------------------------------------------------------
  476-  503 (46.37/67.28)	DDMEKS.INDDMkrIIPWIQQLKFWLGQQ
  981- 1007 (46.40/12.10)	DDNPPSpIGGDM..MDSLISQLQPPPQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.33|      10|      25|    1402|    1411|      12
---------------------------------------------------------------------------
 1402- 1411 (17.56/ 9.14)	PRQQNSSVAA
 1428- 1437 (19.77/11.23)	PRQGECTIFA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27398 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
2) VQLENHQLVPPGGGGGGSGGPASAPAPPPP
970
4
1170
33










Molecular Recognition Features






MoRF SequenceStartStop




NANANA