<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27387

Description Uncharacterized protein
SequenceIRNMVAVQEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPVHQNEAALRGLAGGPGSANGGAHNCRPEAGTAGTPKTIHDLKNRNDIQRLPGPRLDRVGSRKRRGDQRDLGHPGPPPKVSKVSHDSLVPNSSPLPTNGLSGSLESFPGPLDGSGHGPRRQPLESGEMDKHSGKIPINAVSPHTSLPGPGKPPGPCLQTKAAVLQQLDRVDETPGPPHPGPPRCSFSPRNSRHEGPFAQQRSPYTPRGSVPSPSPRPPALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVRWLEQPDGHQRLTGPGCKAGLPPAEPLLPRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEVGVKPVRLKERKLTFDPMTRQIKPLTQKEPVQADSPVHMEQPRTELDKPEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESSRRGARKPHVLVPHGPPVDLPGLTREVMQDDLDRIQAHQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length573
PositionUnknown
OrganismEquus caballus (Horse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Perissodactyla> Equidae> Equus.
Aromaticity0.04
Grand average of hydropathy-0.871
Instability index56.16
Isoelectric point9.41
Molecular weight62585.82
Publications
PubMed=19892987

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27387
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     156.12|      23|      32|     257|     279|       1
---------------------------------------------------------------------------
  195-  214 (25.88/ 6.03)	KIPiN.........AV..SPHT...SLPGPG.KPP
  216-  243 (27.25/ 6.75)	PCL.QtkaavlqqlDR..VDETP.G..P.PHPGPP
  257-  279 (45.57/16.37)	PFA.Q.........QR..SPYTPRGSVPSPSPRPP
  291-  312 (28.42/ 7.37)	PLA.Q.........PS..TPPVRRLEL.LPSAESP
  319-  342 (29.00/ 7.67)	PDG.H.........QRltGPGCKAG.LPPAEPLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.50|      16|      18|      97|     112|       2
---------------------------------------------------------------------------
   97-  112 (28.08/15.59)	PK..TIHDLKNRNDIQRL
  115-  132 (23.43/11.90)	PRldRVGSRKRRGDQRDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.21|      18|      18|     410|     427|       3
---------------------------------------------------------------------------
  391-  409 (22.40/ 8.46)	PVRL..KErKLTFDPMTRQIK
  410-  427 (30.54/13.90)	PLTQ..KE.PVQADSPVHMEQ
  428-  447 (23.27/ 9.04)	PRTEldKP.EAKASLQSPFEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.52|      10|      20|     165|     176|       4
---------------------------------------------------------------------------
  165-  176 (15.31/14.12)	LESfpGPLD.GSG
  184-  194 (16.22/ 6.48)	LES..GEMDkHSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27387 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAHHFMSEYLKQEESSRRGARKPHVLVPHGPPVDLPGLTREVMQDDLDR
2) HQNEAALRGLAGGPGSANGGAHNCRPEAGTAGTPKTIHDLKNRNDIQRLPGPRLDRVGSRKRRGDQRDLGHPGPPPKVSKVSHDSLVPNSSPLPTNGLSGSPESFPGPLDGSGHMGPEGSRLESGEMDKHSGKIPINAVRPHTSSPGLGKPPGPCLQTKAAVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGPFAQQRSPYTPRGSVPSPSPRPPALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVRWLEQPDGHQRLTGPGCKAGLPPAEPLLPRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEVGV
3) PVRLKERKLTFDPMTRQIKPLTQKEPVQADSPVHMEQPRTELDKPEAKASLQSPFEQTNW
505
88
417
553
415
476










Molecular Recognition Features






MoRF SequenceStartStop




1) IRDRLL
2) RRLELL
3) SKKKKRYRPRDYTVNLD
11
327
391
16
332
407