<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27383

Description Mediator complex subunit 23
SequenceMVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGSLSQESHEQCVQWIVRFIHSQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKVLTIPNTVSSAVVQQLLAAREVIAYILERNSCLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKNLQMNDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGNMRISLPGINCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPAPLQAFFQQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVNPPVQIQLPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRERPTLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNAREENPWIPDDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALSVPGTDVGNALLNVVLKSQPLVQRENITAWMNAIGLIITALPEPYWIVLHDRIVSVINSPSFISETEWVGYPFQLFDFTACHQSYSVMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEALLPIIKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLHYMDPICDFLYHMKYMFTGDSVKDQVEKIICNLRPALTLRLRFITHISKMEPAAVPPQTINSGSPAPQPTQVTVNVAMPVTQ
Length1379
PositionTail
OrganismMonodelphis domestica (Gray short-tailed opossum)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Metatheria> Didelphimorphia> Didelphidae> Monodelphis.
Aromaticity0.10
Grand average of hydropathy-0.012
Instability index46.08
Isoelectric point7.00
Molecular weight157915.76
Publications
PubMed=17495919

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27383
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.24|      14|     133|     593|     617|       1
---------------------------------------------------------------------------
  602-  617 (20.42/23.44)	FKSHAWGIlHTlLEMF
  731-  744 (30.82/ 8.02)	FTPHNWAS.HT.LSCF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.14|      13|     133|     375|     393|       3
---------------------------------------------------------------------------
  348-  360 (25.17/15.03)	IFFVLFQFASFPH
  381-  393 (23.97/ 7.08)	LMWVLLQFISGSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.04|      49|     258|     527|     582|       4
---------------------------------------------------------------------------
  527-  582 (67.93/59.75)	GSiTPLPMNLLDSLTVHAKMslIHSIATRVIKLAHAKSSValapALVETYSRLLVY
  793-  841 (88.11/54.92)	GS.PPLFLCLLWKMLLETDH..INQIGYRVLERIGARALV....AHVRTFADFLVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.96|      62|     255|     916|    1009|       6
---------------------------------------------------------------------------
  198-  263 (104.47/46.34)	KLPHWLLGNLVSDFVDTFRPTARI..NSICGRcsLLPVVNNsgAICNSWKLDP.....TTLRFPLKGLLPY.DK
  940- 1009 (96.49/59.60)	KLYFEGLAEQVNPPVQIQLPYLPIyfGNVCLR..FLPVFDI..VIHRFLELLPvskslETLLDHLGGLYKFhDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.30|      19|     789|      85|     105|      14
---------------------------------------------------------------------------
   85-  105 (31.47/25.79)	CLAMAVETGllPPRMVCESLI
  877-  895 (36.83/23.67)	CLAMRSHEG..NEAQVCYFII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     227.73|      70|     117|    1025|    1101|      19
---------------------------------------------------------------------------
 1025- 1101 (120.46/113.44)	LRERPTLKRKLVHA...IIGSLKDNRPQG.W.CLSDTYLK..NAMNAREENPWIpddSYYCRLIgrlvDTMAGKSPGPFPNCDW
 1140- 1216 (107.27/81.43)	LKSQPLVQRENITAwmnAIGLIITALPEPyWiVLHDRIVSviNSPSFISETEWV...GYPFQLF....DFTACHQSYSVMSCSY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27383 with Med23 domain of Kingdom Metazoa
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