<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27375

Description Uncharacterized protein
SequenceMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDVKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQTNSELFTTVLDMLGVLINGTLASDLSNASQGGAEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPKPKPQSYYLEPLPLPPEEEEEDSTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSNTRVDEYPQNTIYRVPPNYSPISAQMMHPPQSALWGYNIMGQPQQPGFFLQNQQLTPGGSRLDPSGSFVPTNTKQALSNMLQRRSGTMMQPPTLHALTSQQQLLQMKLLLRQQAQTRPFQQRQIELAKQEINQPINQSQPIDQAAIFAQQVRPSSQLSQYPGLQQAQSMPHGYTMYGTQMPLQPGGVVLSPGYNPRAYPPSHSSPALMERLRQMQQQPPSGYIQQQAAAYLQPLTGPQRLTHQPLQPSPLVGGGLDAVLTTATTTSHPNLNSVPLPQDQMRQRQQQIRQQRLLQV
Length614
PositionKinase
OrganismOrnithorhynchus anatinus (Duckbill platypus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Monotremata> Ornithorhynchidae> Ornithorhynchus.
Aromaticity0.06
Grand average of hydropathy-0.710
Instability index65.21
Isoelectric point9.23
Molecular weight69283.00
Publications
PubMed=18464734

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27375
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.53|      27|      61|     481|     507|       1
---------------------------------------------------------------------------
  355-  378 (29.88/ 7.57)	GYnimGQPQ..QPGFFL.......QNQQLT.PGG..
  481-  507 (51.51/17.48)	GL...QQAQSMPHGYTMYG.....TQMPLQ.PGGVV
  511-  542 (37.14/10.89)	GY....NPRAYPPSHSSPAlmerlRQMQQQpPSGYI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.62|      17|      19|     431|     448|       2
---------------------------------------------------------------------------
  431-  448 (26.01/17.38)	QQ.AQTRPFQQRQIeLAKQ
  452-  469 (26.61/13.18)	QPiNQSQPIDQAAI.FAQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.14|      20|     282|      32|      58|       3
---------------------------------------------------------------------------
   32-   58 (27.54/33.76)	QNQVNQILSNWreeryqDDVKArQMMH
  328-  347 (39.60/24.22)	QNTIYRVPPNY......SPISA.QMMH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.25|      20|     282|     266|     289|       4
---------------------------------------------------------------------------
  266-  289 (31.37/21.15)	YLEPLPLPpeeeEEDSTSPISQEP
  549-  568 (38.89/17.60)	YLQPLTGP....QRLTHQPLQPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.53|      36|      36|     194|     229|       5
---------------------------------------------------------------------------
  158-  192 (26.32/10.55)	...ES..IDKVRQLLPLPKQtcdviTCEPMGsLIDTKGNK....
  194-  229 (63.63/35.31)	AGFDS..IDKKQGLQVSTKQ.....KVSPWD.LFEGHKNPAPLS
  231-  264 (51.58/27.31)	AWFGTvrVDRK....VIKYE.....EQHHLL.LYHTHPKPKPQS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27375 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LQPLTGPQRLTHQPLQPSPLVGGGLDAVLTTATTTSHPNLNSVPLPQDQMRQRQQQIRQQRLLQ
2) PGGVVLSPGYNPRAYPPSHSSPALMERLRQMQQQPPSGYIQQQAAA
3) QPGFFLQNQQLTPGGSRLDPSGSFVPTNTKQALSNMLQRRSGTMMQPPTLHAL
4) QSYYLEPLPLPPEEEEEDSTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSNTRVDEYPQNTIYRVPPNYSPISAQMMH
550
503
364
263
613
548
416
347










Molecular Recognition Features






MoRF SequenceStartStop




1) YYLEPLPLP
265
273