<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27363

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVTGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPATGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTTTPQTQLQLQQVALQQQQQFQQQQVALQQQQQQQQQFQAQQNAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQLQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPTVAQNQPSQLPPQSQTQPLVSQAPPLPGQMMYTQQQLKLVRPPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQASQIVGSGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPVTAPVVCARKRKFEEDEKQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length748
PositionTail
OrganismEquus caballus (Horse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Perissodactyla> Equidae> Equus.
Aromaticity0.03
Grand average of hydropathy-0.738
Instability index86.95
Isoelectric point9.36
Molecular weight82608.80
Publications
PubMed=19892987

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27363
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.66|      24|      27|     396|     420|       4
---------------------------------------------------------------------------
  278-  303 (40.41/ 7.86)	Q................alPQQLQQMHHPQHHQPPPQPQ.QPT
  377-  419 (36.25/ 9.13)	QivgsgvqvsqnsltmlssPSPGQQVQTPQSMPPPPQPSpQPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.74|      22|      22|     221|     242|       5
---------------------------------------------------------------------------
  225-  247 (37.71/10.69)	QLQQQQQQ..LQRMAQLQL.QqQQQ..Q
  248-  267 (33.59/ 8.45)	QQQQQQQQqaLQ..AQPPI.Q...Q..P
  331-  355 (30.43/ 6.74)	QMMYTQQQ..LKLVRPPMVvQ.QPQvqP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.49|      27|      28|     433|     460|       6
---------------------------------------------------------------------------
   92-  119 (39.43/12.18)	PATGAAGIgMPSRGPGQSLGGMGGLGAM
  129-  150 (40.47/12.20)	PPPGTSGM.....APHG.MAVVSTTTPQ
  433-  459 (50.60/18.59)	PAPSPSSF.LPSPSPQPSQSPVTARTPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.28|      18|      41|     561|     578|       7
---------------------------------------------------------------------------
  534-  548 (21.97/ 6.06)	..TDPSKRCPLKTLQ.KC
  561-  578 (36.68/15.35)	VPTPPPPPVPPTKQQYLC
  603-  620 (31.63/12.16)	VPAMTAIHGPPVTAPVVC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.00|      18|     206|     464|     484|      11
---------------------------------------------------------------------------
  464-  484 (26.93/20.99)	PSPGPLNTPVnPSSVmsPAGS
  676-  693 (35.07/16.23)	PSVPPLELSV.PADY..PAQS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27363 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NALQSLTGGPATGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTTT
2) PSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQ
3) QQVALQQQQQQQQQFQAQQNAMQQQFQAVV
4) RPPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQASQIVGS
5) VLGALQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPTVAQNQPSQLPPQSQTQPLVSQAPPLPG
85
401
171
323
228
150
457
200
361
310










Molecular Recognition Features






MoRF SequenceStartStop




NANANA