<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27363
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MDVTGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPATGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTTTPQTQLQLQQVALQQQQQFQQQQVALQQQQQQQQQFQAQQNAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQLQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPTVAQNQPSQLPPQSQTQPLVSQAPPLPGQMMYTQQQLKLVRPPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQASQIVGSGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPVTAPVVCARKRKFEEDEKQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA |
Length | 748 |
Position | Tail |
Organism | Equus caballus (Horse) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Perissodactyla> Equidae> Equus.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.738 |
Instability index | 86.95 |
Isoelectric point | 9.36 |
Molecular weight | 82608.80 |
Publications | PubMed=19892987
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP27363
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.66| 24| 27| 396| 420| 4
---------------------------------------------------------------------------
278- 303 (40.41/ 7.86) Q................alPQQLQQMHHPQHHQPPPQPQ.QPT
377- 419 (36.25/ 9.13) QivgsgvqvsqnsltmlssPSPGQQVQTPQSMPPPPQPSpQPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 101.74| 22| 22| 221| 242| 5
---------------------------------------------------------------------------
225- 247 (37.71/10.69) QLQQQQQQ..LQRMAQLQL.QqQQQ..Q
248- 267 (33.59/ 8.45) QQQQQQQQqaLQ..AQPPI.Q...Q..P
331- 355 (30.43/ 6.74) QMMYTQQQ..LKLVRPPMVvQ.QPQvqP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 130.49| 27| 28| 433| 460| 6
---------------------------------------------------------------------------
92- 119 (39.43/12.18) PATGAAGIgMPSRGPGQSLGGMGGLGAM
129- 150 (40.47/12.20) PPPGTSGM.....APHG.MAVVSTTTPQ
433- 459 (50.60/18.59) PAPSPSSF.LPSPSPQPSQSPVTARTPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 90.28| 18| 41| 561| 578| 7
---------------------------------------------------------------------------
534- 548 (21.97/ 6.06) ..TDPSKRCPLKTLQ.KC
561- 578 (36.68/15.35) VPTPPPPPVPPTKQQYLC
603- 620 (31.63/12.16) VPAMTAIHGPPVTAPVVC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 62.00| 18| 206| 464| 484| 11
---------------------------------------------------------------------------
464- 484 (26.93/20.99) PSPGPLNTPVnPSSVmsPAGS
676- 693 (35.07/16.23) PSVPPLELSV.PADY..PAQS
---------------------------------------------------------------------------
|