<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27362

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNINFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRNVVDPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDIEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKLSPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSAKGKKRSQPATKTEDYGMGPGRNGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQTGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2152
PositionKinase
OrganismCallithrix jacchus (White-tufted-ear marmoset)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Callitrichinae> Callithrix> Callithrix.
Aromaticity0.07
Grand average of hydropathy-0.508
Instability index57.06
Isoelectric point6.70
Molecular weight240374.82
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27362
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     175.76|      15|      15|    2029|    2043|       1
---------------------------------------------------------------------------
 2029- 2043 (34.24/14.11)	EQQQQQQ...Q..QQQQQQQ
 2046- 2062 (28.24/10.28)	QQQQQQQ...YhiRQQQQQQ
 2066- 2080 (35.47/14.90)	QQQQQQQ...Q..QQQQQQQ
 2081- 2092 (23.02/ 6.95)	...QQQQ...Q..QQQQQHQ
 2093- 2107 (30.76/11.89)	QQQQQQA...A..PPQPQPQ
 2108- 2125 (24.03/ 7.60)	SQPQFQRqglQ..QTQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     172.63|      77|     614|      13|      96|       2
---------------------------------------------------------------------------
   13-   54 (32.17/25.77)	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PLKRPRlGPPDVYPQDPKQKEDELTAlNVKQgfnNQPAVSGD
   55-   96 (39.72/22.54)	EHGSAKNINFNPAKiSSNFsSIIAEKLRCNTLPDTGRRKPQV...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  630-  666 (48.62/21.31)	..........................................nqkdnfwlvtarsqsaintwftdlagtkpltqlakkvpifskkeevfgylakytvpvmraawlikmtcayyaaisetkvkkrnvvdpftewtqiitkylweqlqkmaeyyrpgpagsggcgstigplphdvevairqwdyneklamfmfqdgmldrhefltwvlecfekirpgedellklllplllrysgefvqsaylsrrlayfctrrlalqldgvsshsshvisaqststlpttpapqpptsstpstpfsdllmcpqhrplvfglscilqtillccpsalvwhysltdsriktgspldhlpiapsnlpmpegnsaftqqvraklreieqqikergqavevrwsfdkcqeatagftigrvlhtlevldshsfersdfsnsldslcnrifglgpskdgheissdddavvsllcewavsckrsgrhramvvakllekrqaeieaercgeseaadekgsiasgslsapsapifqdvllqfldtqapmltdprseserveffnlvllfcelirhdvfshnmytctlisrgdlafgaPGPRPP.SPFDDPADDPERKEAEGSS.SSKL...EDPGLSES
  668-  707 (52.12/22.75)	DIDPSSSVLFEDME.KPDF.SLFSPTMPCEGKGSPSPEKPDI...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.10|      28|     613|     523|     552|       3
---------------------------------------------------------------------------
  523-  552 (42.61/31.97)	AMVVAK...LLEK..RQAEIEA...ERCGESEAadEKG
 1134- 1169 (34.49/19.15)	AILIARqclLLEDliRCAAIPSllnAACSEQDS..EPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     257.17|      41|      44|    1923|    1963|       4
---------------------------------------------------------------------------
 1790- 1827 (43.62/18.02)	....GK..KR..SQPATKTEDYGMGPGRN.GPYGVTVppD..L..LH.HPNP
 1837- 1873 (44.24/18.39)	QGSIGL..YT..QNQPLPA...GGPRVDPYRP....V..R..LpmQKlPTRP
 1876- 1918 (44.12/18.32)	PGVLPTtmTG..VMGLEP.SSYKTSVYRQQQPAVPQ...GqrL..RQ.QLQA
 1923- 1963 (76.88/37.60)	QGMLGQ..SS..VHQMTPSSSYGLQTSQGYTPYVSHV..G..L..QQ.HTGP
 1968- 2004 (48.31/20.79)	RHLQQR..PSgyVHQQAPTYGHGLTSTQRF....SHQ..T..L..QQ...TP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      16|     854|     868|       5
---------------------------------------------------------------------------
  854-  868 (26.85/18.06)	LEQITSFALG.MSYHL
  870-  885 (23.14/14.48)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.83|      15|      16|    1733|    1748|       6
---------------------------------------------------------------------------
 1733- 1748 (27.55/18.67)	PrPRAYYLEPL...PLPPE
 1752- 1769 (26.28/12.56)	P.PAPTLLEPEkkaPEPPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1028|    1040|       7
---------------------------------------------------------------------------
 1028- 1040 (25.11/17.09)	ENPAA.HTFTYTGL
 1046- 1059 (21.03/12.97)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.92|      14|      15|    1329|    1343|      12
---------------------------------------------------------------------------
 1329- 1343 (22.34/14.96)	HRLLDNEDgENPQRQ
 1346- 1359 (26.58/13.13)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     313.04|     102|     205|    1191|    1301|      13
---------------------------------------------------------------------------
 1191- 1301 (151.01/130.27)	SDGNKPTVGIRSSCDRHLLaASQNRivdGAVFAVLKAVFVLgDAELKGSGFTVTGgtEELpeEEGGG.GSGGRRQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSL
 1400- 1504 (162.03/108.73)	SSGNTASNMPSSSKTKPVL.SSLER...SGVWLVAPLIAKL.PTSVQGHVLKAAG..EEL..EKGQHlGSSSRKERDRqkQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      14|     663|     122|     135|      16
---------------------------------------------------------------------------
  122-  135 (24.94/16.27)	GTKPLTQLAKKVPI
  787-  800 (25.11/16.45)	GTAETDQLAPIVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.57|      15|      18|    1664|    1681|      19
---------------------------------------------------------------------------
 1664- 1681 (17.95/20.06)	NKIAGFDsIFkkEGLQVS
 1684- 1698 (29.63/18.02)	QKLSPWD.LF..EGLKPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27362 with Med12 domain of Kingdom Metazoa
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