<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27357
| Description |
F-box and WD repeat domain containing 7 |
| Sequence | MTSSVGLEAAAAAAVAAVAETAAEAAVAVAAAATAATAAAAAATAAAAAVAAAAVAAAATAAAAATAVAVSAAATAAAAAATRISDAKLKDEKGERTVILDLSRKSLQSVAYWIGIGPEVRSSVPNSSTDLQFDFGQNVKTFASSDSLAKVQEVASWLLEMNQELLSVGSKRRRTGSSLRGNSSSSQVDEDQMNRVVEEEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLRQEEEHIARNGEVIGAEPRHGDQNDSQQGQLEENNNRFISVDEESTGIQEEQEDEEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTNSNSVTNSNSIMDLPIHQLSSPFYTKTSKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAITGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK |
| Length | 892 |
| Position | Tail |
| Organism | Monodelphis domestica (Gray short-tailed opossum) |
| Kingdom | Metazoa |
| Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Metatheria> Didelphimorphia> Didelphidae> Monodelphis.
|
| Aromaticity | 0.05 |
| Grand average of hydropathy | -0.498 |
| Instability index | 50.95 |
| Isoelectric point | 5.36 |
| Molecular weight | 98331.51 |
| Publications | PubMed=17495919
|
Function
| Annotated function |
|
| GO - Cellular Component | cytoplasm GO:0005737 IBA:GO_Central
endoplasmic reticulum GO:0005783 IEA:Ensembl
Golgi apparatus GO:0005794 IEA:Ensembl
mitochondrion GO:0005739 IEA:Ensembl
nucleolus GO:0005730 IEA:Ensembl
nucleus GO:0005634 IBA:GO_Central
Parkin-FBXW7-Cul1 ubiquitin ligase complex GO:1990452 IEA:Ensembl
perinuclear region of cytoplasm GO:0048471 IEA:Ensembl
SCF ubiquitin ligase complex GO:0019005 IEA:Ensembl
|
| GO - Biological Function | cyclin binding GO:0030332 IEA:Ensembl
identical protein binding GO:0042802 IEA:Ensembl
phosphothreonine residue binding GO:0050816 IEA:Ensembl
protein-macromolecule adaptor activity GO:0030674 IEA:Ensembl
ubiquitin binding GO:0043130 IBA:GO_Central
ubiquitin protein ligase binding GO:0031625 IEA:Ensembl
ubiquitin-protein transferase activator activity GO:0097027 IEA:Ensembl
|
| GO - Biological Process | lung development GO:0030324 IEA:Ensembl
negative regulation of gene expression GO:0010629 IEA:Ensembl
negative regulation of osteoclast development GO:2001205 IEA:Ensembl
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1903026 IEA:Ensembl
Notch signaling pathway GO:0007219 IEA:Ensembl
positive regulation of epidermal growth factor-activated receptor activity GO:0045741 IEA:Ensembl
positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA:Ensembl
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903378 IEA:Ensembl
positive regulation of proteasomal protein catabolic process GO:1901800 IEA:Ensembl
positive regulation of protein targeting to mitochondrion GO:1903955 IEA:Ensembl
positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 IEA:Ensembl
positive regulation of ubiquitin-protein transferase activity GO:0051443 IEA:Ensembl
proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA:GO_Central
protein destabilization GO:0031648 IEA:Ensembl
protein stabilization GO:0050821 IEA:Ensembl
protein ubiquitination GO:0016567 IEA:Ensembl
regulation of autophagy of mitochondrion GO:1903146 IEA:Ensembl
regulation of cell migration involved in sprouting angiogenesis GO:0090049 IEA:Ensembl
regulation of circadian rhythm GO:0042752 IEA:Ensembl
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IEA:Ensembl
sister chromatid cohesion GO:0007062 IEA:Ensembl
ubiquitin recycling GO:0010992 IBA:GO_Central
vasculogenesis GO:0001570 IEA:Ensembl
|
Interaction
Repeat regions
| Repeats |
>MDP27357
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 104.65| 15| 15| 35| 49| 1
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19- 33 (23.61/12.82) AETAAEAAVAVAAAA
35- 49 (28.01/16.45) AATAAAAAATAAAAA
51- 65 (27.09/15.69) AAAAVAAAATAAAAA
66- 80 (25.94/14.75) TAVAVSAAATAAAAA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 66.75| 17| 17| 201| 217| 2
---------------------------------------------------------------------------
201- 217 (34.23/15.35) QQQQQQQQQQQQQQQQQ
219- 235 (32.52/14.28) QQQQQQQQQQQQLRQEE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
7| 443.69| 38| 38| 625| 662| 3
---------------------------------------------------------------------------
549- 582 (35.15/16.94) .......NWRRGElkSPKVLKG...HDDhVITCLQFCGNRIVSG
585- 622 (66.41/38.31) DNTLKVWSAITGK..CLRTLVG...HTG.GVWSSQMRDNIIISG
625- 662 (73.46/43.13) DRTLKVWNAETGE..CIHTLYG...HTS.TVRCMHLHEKRVVSG
665- 702 (71.29/41.65) DATLRVWDIETGQ..CLHVLMG...HVA.AVRCVQYDGRRVVSG
705- 742 (70.77/41.30) DFMVKVWDPETET..CLHTLQG...HTN.RVYSLQFDGIHVVSG
745- 782 (63.54/36.35) DTSIRVWDVETGN..CIHTLTG...HQS.LTSGMELKDNILVSG
785- 825 (63.08/36.04) DSTVKIWDIKTGQ..CLQTLQGpnkHQS.AVTCLQFNKNFVITS
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 111.24| 31| 32| 258| 289| 4
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238- 258 (24.07/10.36) ..........IARNGEVIGAEPRHGD....QNDSQ
260- 290 (50.50/31.98) GQLEENNNRFISVDEESTGIQEEQED....EEEHA
291- 322 (36.66/16.84) GEQDEEDEEEEEMDQESDDF..DQSDdssrEDEH.
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 71.87| 16| 33| 369| 384| 5
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369- 384 (26.29/18.74) GKKPCKVSEYTSTTGL
388- 403 (21.60/13.94) SATPTTFGDLRAANGQ
404- 419 (23.98/16.38) GQQRRRITSVQPPTGL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.85| 14| 15| 505| 518| 7
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505- 518 (27.00/16.59) LWREKCKEEG.IDEP
521- 535 (20.84/11.35) IKRRKIIKPGfIHSP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 77.48| 26| 32| 119| 145| 8
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119- 145 (37.59/26.45) EVRSSVPNSSTDLqFDFGQNVKTFASS
153- 178 (39.88/23.58) EVASWLLEMNQEL.LSVGSKRRRTGSS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 35.56| 11| 22| 829| 840| 9
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829- 840 (15.46/12.41) GTVkLWDLKTGE
854- 864 (20.09/11.20) GGV.VWRIRASN
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|
