<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27357

Description F-box and WD repeat domain containing 7
SequenceMTSSVGLEAAAAAAVAAVAETAAEAAVAVAAAATAATAAAAAATAAAAAVAAAAVAAAATAAAAATAVAVSAAATAAAAAATRISDAKLKDEKGERTVILDLSRKSLQSVAYWIGIGPEVRSSVPNSSTDLQFDFGQNVKTFASSDSLAKVQEVASWLLEMNQELLSVGSKRRRTGSSLRGNSSSSQVDEDQMNRVVEEEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLRQEEEHIARNGEVIGAEPRHGDQNDSQQGQLEENNNRFISVDEESTGIQEEQEDEEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTNSNSVTNSNSIMDLPIHQLSSPFYTKTSKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAITGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK
Length892
PositionTail
OrganismMonodelphis domestica (Gray short-tailed opossum)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Metatheria> Didelphimorphia> Didelphidae> Monodelphis.
Aromaticity0.05
Grand average of hydropathy-0.498
Instability index50.95
Isoelectric point5.36
Molecular weight98331.51
Publications
PubMed=17495919

Function

Annotated function 
GO - Cellular Component
cytoplasm	GO:0005737	IBA:GO_Central
endoplasmic reticulum	GO:0005783	IEA:Ensembl
Golgi apparatus	GO:0005794	IEA:Ensembl
mitochondrion	GO:0005739	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleus	GO:0005634	IBA:GO_Central
Parkin-FBXW7-Cul1 ubiquitin ligase complex	GO:1990452	IEA:Ensembl
perinuclear region of cytoplasm	GO:0048471	IEA:Ensembl
SCF ubiquitin ligase complex	GO:0019005	IEA:Ensembl

GO - Biological Function
cyclin binding	GO:0030332	IEA:Ensembl
identical protein binding	GO:0042802	IEA:Ensembl
phosphothreonine residue binding	GO:0050816	IEA:Ensembl
protein-macromolecule adaptor activity	GO:0030674	IEA:Ensembl
ubiquitin binding	GO:0043130	IBA:GO_Central
ubiquitin protein ligase binding	GO:0031625	IEA:Ensembl
ubiquitin-protein transferase activator activity	GO:0097027	IEA:Ensembl

GO - Biological Process
lung development	GO:0030324	IEA:Ensembl
negative regulation of gene expression	GO:0010629	IEA:Ensembl
negative regulation of osteoclast development	GO:2001205	IEA:Ensembl
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	GO:1903026	IEA:Ensembl
Notch signaling pathway	GO:0007219	IEA:Ensembl
positive regulation of epidermal growth factor-activated receptor activity	GO:0045741	IEA:Ensembl
positive regulation of ERK1 and ERK2 cascade	GO:0070374	IEA:Ensembl
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	GO:1903378	IEA:Ensembl
positive regulation of proteasomal protein catabolic process	GO:1901800	IEA:Ensembl
positive regulation of protein targeting to mitochondrion	GO:1903955	IEA:Ensembl
positive regulation of ubiquitin-dependent protein catabolic process	GO:2000060	IEA:Ensembl
positive regulation of ubiquitin-protein transferase activity	GO:0051443	IEA:Ensembl
proteasome-mediated ubiquitin-dependent protein catabolic process	GO:0043161	IBA:GO_Central
protein destabilization	GO:0031648	IEA:Ensembl
protein stabilization	GO:0050821	IEA:Ensembl
protein ubiquitination	GO:0016567	IEA:Ensembl
regulation of autophagy of mitochondrion	GO:1903146	IEA:Ensembl
regulation of cell migration involved in sprouting angiogenesis	GO:0090049	IEA:Ensembl
regulation of circadian rhythm	GO:0042752	IEA:Ensembl
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:0031146	IEA:Ensembl
sister chromatid cohesion	GO:0007062	IEA:Ensembl
ubiquitin recycling	GO:0010992	IBA:GO_Central
vasculogenesis	GO:0001570	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27357
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     104.65|      15|      15|      35|      49|       1
---------------------------------------------------------------------------
   19-   33 (23.61/12.82)	AETAAEAAVAVAAAA
   35-   49 (28.01/16.45)	AATAAAAAATAAAAA
   51-   65 (27.09/15.69)	AAAAVAAAATAAAAA
   66-   80 (25.94/14.75)	TAVAVSAAATAAAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.75|      17|      17|     201|     217|       2
---------------------------------------------------------------------------
  201-  217 (34.23/15.35)	QQQQQQQQQQQQQQQQQ
  219-  235 (32.52/14.28)	QQQQQQQQQQQQLRQEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     443.69|      38|      38|     625|     662|       3
---------------------------------------------------------------------------
  549-  582 (35.15/16.94)	.......NWRRGElkSPKVLKG...HDDhVITCLQFCGNRIVSG
  585-  622 (66.41/38.31)	DNTLKVWSAITGK..CLRTLVG...HTG.GVWSSQMRDNIIISG
  625-  662 (73.46/43.13)	DRTLKVWNAETGE..CIHTLYG...HTS.TVRCMHLHEKRVVSG
  665-  702 (71.29/41.65)	DATLRVWDIETGQ..CLHVLMG...HVA.AVRCVQYDGRRVVSG
  705-  742 (70.77/41.30)	DFMVKVWDPETET..CLHTLQG...HTN.RVYSLQFDGIHVVSG
  745-  782 (63.54/36.35)	DTSIRVWDVETGN..CIHTLTG...HQS.LTSGMELKDNILVSG
  785-  825 (63.08/36.04)	DSTVKIWDIKTGQ..CLQTLQGpnkHQS.AVTCLQFNKNFVITS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.24|      31|      32|     258|     289|       4
---------------------------------------------------------------------------
  238-  258 (24.07/10.36)	..........IARNGEVIGAEPRHGD....QNDSQ
  260-  290 (50.50/31.98)	GQLEENNNRFISVDEESTGIQEEQED....EEEHA
  291-  322 (36.66/16.84)	GEQDEEDEEEEEMDQESDDF..DQSDdssrEDEH.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.87|      16|      33|     369|     384|       5
---------------------------------------------------------------------------
  369-  384 (26.29/18.74)	GKKPCKVSEYTSTTGL
  388-  403 (21.60/13.94)	SATPTTFGDLRAANGQ
  404-  419 (23.98/16.38)	GQQRRRITSVQPPTGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.85|      14|      15|     505|     518|       7
---------------------------------------------------------------------------
  505-  518 (27.00/16.59)	LWREKCKEEG.IDEP
  521-  535 (20.84/11.35)	IKRRKIIKPGfIHSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.48|      26|      32|     119|     145|       8
---------------------------------------------------------------------------
  119-  145 (37.59/26.45)	EVRSSVPNSSTDLqFDFGQNVKTFASS
  153-  178 (39.88/23.58)	EVASWLLEMNQEL.LSVGSKRRRTGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.56|      11|      22|     829|     840|       9
---------------------------------------------------------------------------
  829-  840 (15.46/12.41)	GTVkLWDLKTGE
  854-  864 (20.09/11.20)	GGV.VWRIRASN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27357 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) VGSKRRRTGSSLRGNSSSSQVDEDQMNRVVEEEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLRQEEEHIARNGEVIGAEPRHGDQNDSQQGQLEENNNRFISVDEESTGIQEEQEDEEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTNSNSVTNSNSIMDLPIHQLSSPFYTKTSKMKR
168
355










Molecular Recognition Features






MoRF SequenceStartStop




1) QQQQLRQEEEHI
2) YWIGIGPE
227
112
238
119