<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27353

Description Mediator complex subunit 14
SequenceMPPVQLESSQLVVSGGPTSVPQPPPPGTVVASTAASHGYRLSTLIEFLLQRTYQELNVLADLLPRKSDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISNFLDQQTILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKNEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADDKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVDRYLAGKFLTLIVWNQQVLGRKTGTASVHKVTVKIDETDCSKTLQISHEPPLPACDSKLMERAMRIDHLSIEKLLIDSVHARSHQKLQELKTILKSFNPSDNSFVETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLYGFDQTTLDDMEKSINDDMKRIIPWLQQLKFWLGQQRCRHSVKHLPTVCSETLHLTNYTTHPISNLSRHSLYIKLTRLPQYYIVVEMFEVPGSPTQLEYAYHFLSVSHTEGEDNPPTALVLQKFKPNVEDLALDGACRKQVKAGNKRKLSGEQGSPESKKPKRTGEICAFNKVLAHFVAMCDSNMPFIGLRMELSTMEIPHQGVQIEGDGFSHAIRLLRVPPCKGTSEETQKALEQSLLDCTFRLQGRNNRTWVAELVFANCPLNSIVSREQGPTRHVNLTYENPLSEPVGGRKVVEMFLNDWNSIARLYDCVLEFSRSLQDIPAHLNMFCEVRVYNYRKLILCYGPTKGSSISIQWNSVHRKFHISLGTVGPNSGCSNCHNIILHQLQEMFNKVPNVVQLLQVLYDTQAPLTSINKLPTVPMLGLTQRINTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLLSQLQPQGQQTQQFTKQMGASGAYPLTSPPSSYHNTVTPSPSMMHSQSPGNLQSSPSGVLRAPSPASFGPTPSPSSLGISMVPTSNFASPHGALDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQSMPTNMPPPRKLPQRSWAASIPTILTHSALHVLLLPSPTPGLAPALAGSYLCSPLERFLGSVNMRRHLQRIIQQETLQLINSNEPGVIMFKTDVLKCRVALNPTTNQTLQLKVTPENAGQWKPEELQVLERFFETRVAGPPFKANTLIAFTKLLGAPAHILRDCVHIMKLELFPDQTTQLKWNVQFCLTIPPSAPPIAPSGTPAVVLKSKMLFFLQLTQKTSAPTDAFSIIVPIIYDMASGTTQQAEIPRQQNSSVTAPLTVSNILKRFAEMNPPRPGECTIFAAVRDLMANLTLPPGGRP
Length1442
PositionTail
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Silurana.
Aromaticity0.07
Grand average of hydropathy-0.205
Instability index53.25
Isoelectric point8.78
Molecular weight160385.21
Publications
PubMed=20431018

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27353
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     143.17|      24|      32|    1012|    1035|       1
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 1012- 1033 (37.85/16.60)	............LTSP.PS.SYHNTVTP.SP.SMMH.SQ
 1034- 1067 (21.97/ 6.31)	SPgnlqsspsgvLRAPsPA.SFGP..TP.SP.SSLGiSM
 1068- 1093 (25.85/ 8.82)	VP..........T.SN.FA.SPHGALDPsSPyTMMSpSQ
 1113- 1134 (30.79/12.02)	MP..........GMSP.ANpSLH...SP.VP.DASH.SP
 1136- 1156 (26.71/ 9.38)	.............AGT.SS.QSMPTNMP.PP.RKLP.QR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     316.02|     102|     123|     188|     292|       2
---------------------------------------------------------------------------
  188-  292 (171.40/126.36)	ILRHR...LVTTD..LPPQLANLTVANGRVKFRVEGEFEA.TLTVMGDDPDIPwrlLKLEILVEDK.ETGDGRALVHSMQINF..IHQLVQSRLFA.DDKPLQDMYNCLHSFCLS
  305-  416 (144.62/97.69)	LIRERwgdLVQVDryLAGKFLTLIVWNQQVLGRKTGTASVhKVTVKIDETDCS...KTLQISHEPPlPACDSKLMERAMRIDHlsIEKLLIDSVHArSHQKLQELKTILKSFNPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     351.40|     111|     123|     674|     793|       3
---------------------------------------------------------------------------
  674-  793 (167.52/129.27)	LLRVPPCKGTSEETQKALEQSLLDCTFRLQGRNNR.TWVAELVFANcpLNSIVSREQGPTRHVNLTYEN..PLSePVGGRKVVEMfLNDWNSIARLYDCvleFSrSLQDIPAHL.....NMFCeVRVY
  799-  917 (183.88/110.49)	ILCYGPTKGSSISIQWNSVHRKFHISLGTVGPNSGcSNCHNIILHQ..LQEMFNKVPNVVQLLQVLYDTqaPLT.SINKLPTVPM.LGLTQRINTAYQC...FS.ILPQSPTHIrlafrNMYC.IDIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.32|      31|     396|     540|     613|       4
---------------------------------------------------------------------------
  540-  573 (51.74/92.10)	IVVEMFEVPGSPTQLEYayhFLSVSH......TEGEDNPP
  939-  975 (51.58/13.94)	IVEGFYPAPGLKTFLNM...FVDSNQdarrrsVNEDDNPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.80|      21|     395|     977|    1007|       6
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  977-  999 (33.30/19.57)	PIGGDMMDSLLSQLQPqgQQTQQ
 1300- 1320 (38.50/31.01)	HILRDCVHIMKLELFP..DQTTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.14|      89|    1313|      17|     113|       8
---------------------------------------------------------------------------
   17-  113 (140.52/98.68)	PTSVPQPPPPGTVVASTAashgyrlSTLIEF..LLQRTYQELNVLADLLPRKSDM....ERKIEIV..QFASRTRQLFVRLLaLVKWAN.NAGKVEKCAMISNFLD
 1332- 1429 (135.61/78.62)	PPSAPPIAPSGTPAVVLK.......SKMLFFlqLTQKTSAPTDAFSIIVPIIYDMasgtTQQAEIPrqQNSSVTAPLTVSNI.LKRFAEmNPPRPGECTIFAAVRD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27353 with Med14 domain of Kingdom Metazoa
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