<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27348
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSDHREAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSATPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICPCSVWVPLGWQPLPGRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLCGGLWWRVPLSYP |
Length | 855 |
Position | Tail |
Organism | Macaca mulatta (Rhesus macaque) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Cercopithecinae> Macaca.
|
Aromaticity | 0.07 |
Grand average of hydropathy | 0.049 |
Instability index | 49.09 |
Isoelectric point | 7.87 |
Molecular weight | 94581.98 |
Publications | PubMed=17431167
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | catalytic activity GO:0003824 IEA:InterPro
thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription coactivator activity GO:0003713 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
positive regulation of transcription, DNA-templated GO:0045893 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP27348
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 135.51| 40| 188| 443| 482| 1
---------------------------------------------------------------------------
443- 482 (70.82/39.28) LVGIDNQGKL.....SVLRLSPSMGHPLEVGLALRHLLFLLEYCM
629- 673 (64.69/35.29) LASLPNQGSLlrpghSFLRDGTSLGMLRELMVVIRIWGLLKPSCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 322.40| 104| 200| 1| 136| 2
---------------------------------------------------------------------------
22- 136 (177.25/156.85) EKWSKSTHCPSVPLACAWSCRNLIAFTMD.......LRSDDQDLTrmihilDTEHPWDLHsipSDHREAITCLEW...DQSGSRLL..SADADGQIKCWSM.ADHL.ANSWESSVGSLVeGD..PIVaLSW
157- 233 (93.72/42.72) EKFSRVKFSPSLTLFGGKPMEGWIAVTVSglvtvslLKPSGQVLT......STESLCRLR...G..RVALADIAF....TGGGNIV..VATADG.....................................
275- 339 (51.43/17.04) ................................................................DKFPAITHLKFlarDMSEQVLLcaSSQTSSIVECWSLrKEGLpVNNIFQQISPVV.GDkqPTI.LKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 78.00| 22| 32| 757| 778| 3
---------------------------------------------------------------------------
757- 778 (41.84/24.22) QPK.QPL.RLQFGRAPTLPGSAAT
790- 813 (36.16/19.95) QPKiDHLrRLHLGACPTEECKACT
---------------------------------------------------------------------------
|