<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27347

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNINFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRNVVDPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDIEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDWGSDQGRGLVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKLSPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSAKGKKRSQPATKTEDYGMGPGRNGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAGIVTLGMRQAALHTLSPDSISPPSLQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQTGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVAAGLQPQAQGQLPRLGTQPVN
Length2165
PositionKinase
OrganismCallithrix jacchus (White-tufted-ear marmoset)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Callitrichinae> Callithrix> Callithrix.
Aromaticity0.07
Grand average of hydropathy-0.487
Instability index56.08
Isoelectric point6.57
Molecular weight241139.81
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27347
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     125.59|      16|      16|    2061|    2076|       1
---------------------------------------------------------------------------
 2061- 2074 (27.28/ 7.36)	...EQQQQQQ....QQQQQQQ
 2075- 2095 (26.36/ 6.92)	QQqQQQQQQQyhirQQQQQQI
 2096- 2111 (34.70/10.97)	LR.QQQQQQQ....QQQQQQQ
 2112- 2127 (37.26/12.21)	QQ.QQQQQQQ....QQHQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.92|      15|      20|    1749|    1768|       2
---------------------------------------------------------------------------
  630-  644 (29.99/10.27)	PGPRPPSPFDDPAD...D
 1751- 1768 (26.93/10.97)	PLPLPPEDEEPPAPtllE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.10|      55|     342|     209|     267|       3
---------------------------------------------------------------------------
  209-  267 (95.05/67.81)	GPAGSGGCGSTIGPLPHDVevaIRQWdYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIR
  552-  606 (94.05/56.09)	GSIASGSLSAPSAPIFQDV...LLQF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.22|      38|     342|     661|     705|       4
---------------------------------------------------------------------------
  661-  705 (54.63/47.04)	PglSESmDIDPSSSVLFEDMEKPDFSLFSPTmpceGKGSPSPEKP
 1011- 1048 (70.58/37.74)	P..SES.NMRWAPEFMIDTLENPAAHTFTYT....GLGKSLSENP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     487.82|     171|     216|    1092|    1307|       5
---------------------------------------------------------------------------
 1076- 1278 (242.57/227.35)	AILCAELTGYCKSL.......saewlgvlKALCCSSnngtcgfNDLLCNVdWGSDQGRGLVSDLSF.HDSLATFVAILIARQCL..LLEDLIRCAAIPSLLN.......AACSEQDS..EPGARLTCRIllhlFKtPQLNPCQSDGNKPTVGIRSSCDRHLLaASQNRivdGAVFAVLKavfVLgdAELKGS..GFTVTGGTEELpeEEGGG.GSGGRRQGGR..NI
 1279- 1481 (245.25/178.44)	SVETASLDVYAKYVlrsicqqewvgerclKSLCEDS.......NDLQDPV.LSSAQAQRLMQLICYpHRLLDNEDGENPQRQRIkrILQNLDQWTMRQSSLElqlmikqTPNNEMNSllENIAKATIEV....FQ.QSAETGSSSGNTASNMPSSSKTKPVL.SSLER...SGVWLVAP...LI..AKLPTSvqGHVLKAAGEEL..EKGQHlGSSSRKERDRqkQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     109.38|      21|      21|    1834|    1854|       6
---------------------------------------------------------------------------
 1834- 1854 (39.10/19.93)	PNPGSITHLN.YRQGS...IGL..............YTQ
 1857- 1876 (25.46/10.15)	PLPAGGPRVDpYR..P...VRL..............PMQ
 1970- 2003 (23.72/ 8.91)	PA.GTMVPPS.YSSQP...YQSthpstnptlvdptrHLQ
 2004- 2025 (21.11/ 7.04)	QRPSGYVH....QQAPtygHGL.............tSTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.34|      24|     344|    1682|    1710|       7
---------------------------------------------------------------------------
 1628- 1651 (36.71/15.15)	KK..LQKELGERQS..DSLEKVRQLLPL
 1683- 1710 (29.63/28.16)	KKegLQVSTKQKLSpwDLFEGLKPSAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     854|     868|       8
---------------------------------------------------------------------------
  854-  868 (26.85/18.48)	LEQITSFALG.MSYHL
  870-  885 (23.14/14.80)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.36|      16|     344|    1784|    1816|       9
---------------------------------------------------------------------------
 1771- 1787 (27.48/28.53)	KKAPEP.PKTDK....P.......gAAPP
 1800- 1828 (13.88/11.39)	KKRSQPaTKTEDygmgPgrngpygvTVPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.38|      20|     123|    1902|    1929|      13
---------------------------------------------------------------------------
 1910- 1929 (38.04/30.52)	QQQPAVPQGQRLRQ.QLQAGI
 2128- 2148 (34.34/11.19)	QQQAAPPQPQPQSQpQVAAGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27347 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALHTLSPDSISPPSLQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQTGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQ
2) FSPTMPCEGKGSPSPEKPDIEKEVKPPPKEKIEGTLGVLY
3) GAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSV
4) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSA
5) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQAGIV
6) QHQQQQQQQAAPPQPQPQSQPQVAAGLQPQAQGQLPRLGTQPVN
7) RAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSAKGKKRSQPATKTEDYGMGPGRNGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVM
1938
688
628
15
1898
2122
1745
2084
727
675
59
1930
2165
1896










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFG
2) QQQAAP
3) QQYHIRQQQQQQILRQQQQQQQQQQQ
1
2128
2083
5
2133
2108