<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27342

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQKIGEQGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAPPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPAPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRVMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAASGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPHQGLGQPQLGPPLLHPPPAQSWPTQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length745
PositionUnknown
OrganismCanis lupus familiaris (Dog) (Canis familiaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Canidae> Canis.
Aromaticity0.05
Grand average of hydropathy-0.236
Instability index59.66
Isoelectric point8.64
Molecular weight77998.75
Publications
PubMed=16341006

Function

Annotated function 
GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27342
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.81|      26|      27|     323|     348|       1
---------------------------------------------------------------------------
  324-  351 (52.02/13.89)	PAPP...L.PP........GPPGAPKPPPASQPSLVStvA
  352-  378 (38.80/ 7.91)	PGPG...LaPP........AQPGAPSMAGTVAPGGVS..G
  652-  686 (35.99/ 6.65)	PPPPqtgV.PPpqaslhhlQPPGAPALLPPHQ.GL.G..Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.05|      23|      30|     564|     591|       2
---------------------------------------------------------------------------
  586-  612 (25.73/ 6.97)	PP...QPQP...qgTVGASAA.SGQpQP.QGaAQ.A
  613-  646 (25.32/ 9.11)	PPgapQGPPgaapgPPPPGPIlRPQ.NPgAN.PQlR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.72|      28|      30|     236|     263|       3
---------------------------------------------------------------------------
  231-  253 (45.10/12.32)	GGG.....SAPGPL........QPK.QPV.PLPPAPPS
  286-  315 (35.59/ 7.77)	QNAVEAAKNQKAGL........GPRfSPInPLQQAAPG
  700-  734 (43.03/11.33)	QSWPTQLPPR.APLpgqmllsgGPR.GPV.PQPGLQPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     174.43|      45|     111|     430|     474|       4
---------------------------------------------------------------------------
  430-  474 (81.87/34.28)	QVYVNHGENL.KTEQWP.................QKLIMQLIPQQLLTTLGPLF....RNS.R.MVQFH
  485-  539 (39.98/13.39)	GLYRIMGNGFaGCVHFPhtapcevrvlmllysskKKIFMGLIPYD...QSG..F....VNGiR...Q..
  540-  585 (52.59/19.68)	.VITNH.KQV.QQQKLE.................QQRVMG..AQQAPPGLGPILedqaRPS.QnLLQLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.27|      30|     111|      39|      69|       5
---------------------------------------------------------------------------
   39-   69 (53.43/37.80)	YLLPAIEYFN.GGPPAETdFGGDYG..GTQYSLV
  151-  183 (43.84/25.52)	YLLPAVESTTySGYTTES.LVQKIGeqGIHFSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.35|      16|     110|     267|     282|       6
---------------------------------------------------------------------------
  200-  216 (24.74/ 7.68)	P.....PaLLEPLQPPTDVSQD
  261-  281 (25.61/ 8.24)	PqqplpP.VPQQYQVPGNLSAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27342 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAPPSGASLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPPAQPGAPSMAGTVAPGGVSGPAPAQLGAPALG
2) HKQVQQQKLEQQRVMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASAASGQPQPQGAAQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPHQGLGQPQLGPPLLHPPPAQSWPTQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
232
544
390
743










Molecular Recognition Features






MoRF SequenceStartStop




NANANA