<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27331

Description Mediator complex subunit 12
SequenceQDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTGTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEACSVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTPLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPMRLPMQKLPTRPPYPGVLPTAVTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSSQRFSHQTLQQTPMMGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQQAHQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNLFGRF
Length2154
PositionKinase
OrganismEquus caballus (Horse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Perissodactyla> Equidae> Equus.
Aromaticity0.07
Grand average of hydropathy-0.504
Instability index57.29
Isoelectric point6.66
Molecular weight240195.46
Publications
PubMed=19892987

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27331
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     191.28|      15|      15|    2022|    2036|       1
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 2022- 2036 (34.58/11.95)	EQQQQQ...QQQQQQQQQ
 2038- 2052 (36.47/12.98)	QQQQQQ...QQQQQQQQQ
 2057- 2074 (31.27/10.16)	QQQQQQilrQQQQQQQQQ
 2075- 2089 (36.47/12.98)	QQQQQQ...QQQQQQQQQ
 2090- 2103 (25.98/ 7.29)	QQQ.AH...QQQQQQAAP
 2104- 2118 (26.51/ 7.58)	PQPQPQ...SQPQFQRQG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     176.00|      29|      29|    1714|    1742|       2
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  599-  629 (38.80/16.62)	G...................prPPSPF..DDPADDPERKEAEGS.SSSKLEDP
 1714- 1741 (47.87/22.44)	......................PPEDE..EPPAPTPLEPEKKAP.EPPKTDKP
 1742- 1771 (32.79/12.77)	G...................aaPPSTE..ERKKKST.KGKKRSQ.PAAKTEDY
 1772- 1795 (31.86/12.17)	G....................mGPGRS..GPYGVT..VP....P.DLLHHANP
 1796- 1844 (24.68/ 7.57)	GsishlsyrqgsiglytqnqplPAGGPrvDPYRPMRL.PMQKLPtRPP...YP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     399.08|     131|     230|     185|     349|       3
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  185-  331 (210.12/135.00)	GSTIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSAQStGTLpttPAPQPPTSSTPSTPFSD....LLMCPQ...HRPLVFGL
  419-  565 (188.96/91.55)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERC.....GESEAADEKGSIAS.GSL...SAPSAPIFQDVLLQFLDtqapMLTDPRsesERVEFFNL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     822|     836|       4
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  822-  836 (26.85/16.57)	LEQITSFALG.MSYHL
  838-  853 (23.14/13.24)	LVQHVQFIFDlMEYSL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     752.13|     198|     206|    1202|    1405|       5
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 1033- 1199 (184.80/117.13)	.............................GHHDPDRvnDIAILCAELTGYCKSL.....SAEWLG..VLKALCCSSNngtcgfndllcnvDV.....SDLSFHDSLATFVAILIA......................RQCL..LLEDLIRCAAIPSLLNAACSEQDS...ePGARLTC..riLLHLFKTPQLNPCQ.......SDGNKPTVGIRSSCDRHLLaASQNRivdGAVFAVLKAVFVL
 1201- 1404 (314.41/225.61)	DAELKGSGFTVTGgtEELpeEEGGG.GSGGRRQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSN.............DL.....QDPVLSSAQAQRLMQLICYPHRLLD.......NEDGenPQRQRIKRILQNLDQWTMRQSSLELQLMIKQT....PNNEMNS....LLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVL.SSLER...SGVWLVAPLIAKL
 1405- 1610 (252.92/165.20)	PTSVQGHVLKAAG..EEL..EKGQHlGSSSRKERDRqkQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVH.............QIvnnwrDDQYLDD..........CKPKQLMHealklrlNLVG..GMFDTVQRSTQQTTEWAV....LLLEIIISGTvdmqSNNELFTtvldMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKEL.GERQS...DSLEKVRQLL.PL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.58|      15|      17|    2119|    2133|       7
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 2119- 2133 (25.17/12.18)	LQQTQQQQQTAALVR
 2139- 2153 (27.42/14.00)	LSNTQPQPSTNLFGR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|     996|    1008|       8
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  996- 1008 (25.11/14.32)	ENPAA.HTFTYTGL
 1014- 1027 (21.03/10.85)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     208.79|      44|      44|    1854|    1897|      10
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 1854- 1893 (62.23/28.99)	........VMGLEP.SSYKTSVYRQQQPA.....V....PQ.GQRLRQQLQAKIQSQGM
 1894- 1933 (48.40/20.78)	LGQS...sVHQMTPsSSYGLQTSQGYTPY.....V....SHvG......LQQHTGPAG.
 1934- 1970 (43.47/17.84)	..........TMVP.PSYSSQPYQSTHPStnptlV....DP.TRHLQQRPS......GY
 1971- 2019 (54.70/24.52)	VHQQaptyGHGLTS.SQRFSHQTLQQTPM.....MgtmtPL.GA...QGVQAGVRSASI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27331 with Med12 domain of Kingdom Metazoa
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